Using model fish to study the biological mechanisms of cooperative behaviour: A future for translational research concerning social anxiety disorders?

Soares, Marta C.; Cardoso, Sónia C.; Carvalho, Tamires dos Santos; Maximino, Caio

doi:10.1016/j.pnpbp.2017.11.014

Cited by 30 publications

(40 citation statements)

References 177 publications

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Section: A Way Forward: Integration Between Stress and Sociality In Fishmentioning

confidence: 79%

“…For instance, the Indo-pacific cleaner wrasse Labroides dimidiatus (Valenciennes 1839) is able to engage in thousands of interactions a day and may feed on more than 1200 "clients" daily (Grutter, 1999). The behaviour of these cleaners has been described in detail over the last few decades Soares, 2017;Soares et al, 2017c), which deemed them to be appropriate for developing and testing new paradigms on the proximate mechanisms that render altruistic behaviour as psychologically rewarding (Soares, 2017). One of the most notable behaviours by these animals, is the entering of predators' mouths (while cleaning), a behaviour that has been interpreted as altruistic on behalf of the clients that may simply eat the cleaner (Trivers, 1971).…”

Section: Stress Monoamines and Cooperation: Insights From The Cleanementioning

confidence: 99%

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The Integration of Sociality, Monoamines, and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences

Soares

Maximino

2018

Preprint

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Animal-focused research has been crucial for scientific advancement however, in this matter, rodents are still taking a starring role. Coming out from merely being supportive of evidence found in rodents, the use of fish models has slowly taken a more central role and expanded its overall contributions in areas such as social sciences, evolution, physiology, and recently in translational medical research. In neurosciences, zebrafish has been widely adopted, contributing to our understanding of the genetic control of brain processes, and the effects of pharmacological manipulations. However, discussion continues regarding the paradox of function versus structure, when fish and mammals are compared, and on the potentially evolutionarily conserved nature of behaviour across fish species. From the behavioural stand point we explored aversive/stress and social behaviour in selected fish models, and refer to the extensive contributions of stress and monoaminergic systems. We suggest that, in spite of marked neuroanatomical differences between fish and mammals, stress and sociality are conserved at the behavioural and molecular levels. We also suggest that stress and sociality are mediated by monoamines in predictable and non-trivial ways, and that monoamines could "bridge" the relationship between stress and social behaviour. To reconcile the level of divergence with the level of similarity, we need neuroanatomical, pharmacological, behavioural, and ecological studies conducted in the laboratory and in nature.These areas need to add to each other to enhance our understanding of fish behaviour and ultimately how this all may translate to better model systems for translational studies.

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Section: A Way Forward: Integration Between Stress and Sociality In Fishmentioning

confidence: 79%

Section: Stress Monoamines and Cooperation: Insights From The Cleanementioning

confidence: 99%

The Integration of Sociality, Monoamines, and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences

Soares

Maximino

2018

Preprint

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“…It has been suggested (Trower & Gilbert, 1989) that individuals with social anxiety disorder suffer from alterations in mechanisms that select socially appropriate behaviour, always acting "as if" they are in a subordinate position. The emergence of fish as model organisms in biological psychiatry (Kalueff et al, 2014;Soares et al, 2017c) positions the findings reported in this review in this larger context. An example is the reported application of social behaviour in zebrafish models of FASD, which shows the potential of these approaches in the discovery of targets and basic mechanisms involved in brain diseases.…”

Section: A Way Forward: Integration Between Stress and Sociality In Fishmentioning

confidence: 79%

“…For instance, the Indo-pacific cleaner wrasse Labroides dimidiatus is able engage in thousands of interactions a day and may feed on more than 1200 "clients" daily (Grutter, 1999). These cleaners' behaviour has been described in detail during the last few decades Soares, 2017;Soares et al, 2017c), which deemed them to be appropriate for developing and testing new paradigms on the proximate mechanisms that render altruistic behaviour as psychologically rewarding (Soares, 2017).…”

Section: Stress Monoamines and Cooperation: Insights From The Cleanementioning

confidence: 99%

The Integration of Sociality, Monoamines, and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences

Soares¹,

Maximino²

2018

Preprint

Self Cite

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Animal-focused research has been crucial for scientific advancement however, in this matter, rodents are still taking a starring role. Coming out from merely being supportive of evidence found in rodents, the use of fish models has slowly taken a more central role and expanded its overall contributions in areas such as social sciences, evolution, physiology, and recently in translational medical research. In neurosciences, zebrafish has been widely adopted, contributing to our understanding of the genetic control of brain processes, and the effects of pharmacological manipulations. However, discussion continues regarding the paradox of function versus structure, when fish and mammals are compared, and on the potentially evolutionarily conserved nature of behaviour across fish species. From the behavioural stand point we explorted aversive/stress and social behaviour in selected fish models, and refer to the extensive contributions of stress and monoaminergic systems. We suggest that, in spite of marked neuroanatomical differences between fish and mammals, stress and sociality are conserved at the behavioural and molecular levels. We also suggest that stress and sociality are mediated by monoamines in predictable and non-trivial ways, and that monoamines could “bridge” the relationship between stress and social behaviour. To reconcile the level of divergence with the level of similarity, neuroanatomy, pharmacology, behavioural analysis, and ecology studies conducted in the laboratory and in nature need to add to each other and enhance our understanding of fish behaviour and ultimately how this all may translate to better model systems for translational studies.

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“…(a) Intersections between structures involved in the aversive behaviour network, social behaviour network and mesolimbic reward network in the vertebrate brain. Structure names refer to mammalian nomenclature (adapted from Soares et al ., ). NAcc, nucleus accumbens; VTA, ventral tegmental area.…”

Section: Stress and Sociality Network In The Vertebrate Brainmentioning

confidence: 99%

The integration of sociality, monoamines and stress neuroendocrinology in fish models: applications in the neurosciences

Soares

Maximino

2018

Journal of Fish Biology

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Animal-focused research has been crucial for scientific advancement, but rodents are still taking a starring role. Starting as merely supporting evidence found in rodents, the use of fish models has slowly taken a more central role and expanded its overall contributions in areas such as social sciences, evolution, physiology and recently in translational medical research. In the neurosciences, zebrafish Danio rerio have been widely adopted, contributing to our understanding of the genetic control of brain processes and the effects of pharmacological manipulations. However, discussion continues regarding the paradox of function versus structure, when fishes and mammals are compared and on the potentially evolutionarily conserved nature of behaviour across fish species. From a behavioural standpoint, we explore aversive-stress and social behaviour in selected fish models and refer to the extensive contributions of stress and monoaminergic systems. We suggest that, in spite of marked neuroanatomical differences between fishes and mammals, stress and sociality are conserved at the behavioural and molecular levels. We also suggest that stress and sociality are mediated by monoamines in predictable and non-trivial ways and that monoamines could bridge the relationship between stress and social behaviour. To reconcile the level of divergence with the level of similarity, we need neuroanatomical, pharmacological, behavioural and ecological studies conducted in the laboratory and in nature. These areas need to add to each other to enhance our understanding of fish behaviour and ultimately how this all may lead to better model systems for translational studies.

show abstract

Using model fish to study the biological mechanisms of cooperative behaviour: A future for translational research concerning social anxiety disorders?

Cited by 30 publications

References 177 publications

The Integration of Sociality, Monoamines, and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences

The Integration of Sociality, Monoamines, and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences

The Integration of Sociality, Monoamines, and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences

The integration of sociality, monoamines and stress neuroendocrinology in fish models: applications in the neurosciences

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