Using Microwave and ultrasound to prepare of substituted Bis-acyl hydrazone Derivatives

Abstract

In this paper, some new bis-acyl hydrazone derivatives (4a-f) were prepared through the reaction of carboxylic acid hydrazides with 1,4-diacetylbenzene using classical methods, microwave and ultrasound irradiation methods. These compounds are obtained through a series of reactions where some carboxylic acids react with ethanol first in the presence of concentrated sulfuric acid to give the corresponding esters (2a-f), which when treatment with aqueous hydrazine give carboxylic acid hydrazides (3a-f).thus, The results proved that the use of microwave and ultrasound techniques is much better than the classical methods, as it gave a higher yield, shorter reaction time, and the absence of the use of solvents. All newly synthesized compounds were confirmed by IR, ( 1 H & 13 C) NMR spectral analysis and the corresponding reactions were monitored by TLC using the reported eluent.

Green Synthesis and Anti-microbial Activities of Some Thiazole-imino Derivatives

“…Looking at the diversified numerous applications of imines and thiazoles in varied fields of chemistry, there has always been attractive developments pertaining to greener, economical, efficient and feasible methods for their synthesis viz., in aqueous media [17,18]; using catalysts [19][20][21][22][23][24]; using Microwave Irridiation method [25,26]. In addition to all these findings; in this research paper, we herein report the green synthesis and anti-microbial evaluation of few thiazole-imino derivatives obtained from furfural imine and substituted acetophenone.…”

Water Bath Sonicator As An Eco-friendly Technique for Synthesis of New Dihydrazide Hydrazone Derivatives

“…The keto-keto form is more stable than the others. (Cucinotta, Ruini, Catellani, & Stirling, 2006;El-Saied, Shakdofa, Abdou, Abd-Elzaher, & Morsy, 2017;Mohammed, Sheat, Abood, & Yahya, 2021)…”