Using mesenchymal stem cells as a therapy for bone regeneration and repairing

Shao, Jian Yong; Zhang, Weiwei; Yang, Tieyi

doi:10.1186/s40659-015-0053-4

Cited by 71 publications

(49 citation statements)

References 85 publications

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“…The main characteristic quality of MSCs is that it is positive at least for CD73, CD90, and CD105 and negative to CD45, CD34, CD14 (Álvarez-Viejo et al, 2015;Bühring et al, 2007;Harichandan & Bühring, 2011;Pogozhykh et al, 2015). Nevertheless, MSCs derived from bone marrow are the best candidate for bone engineering, as compared with other MSCs sources, mainly through the highly chondrogenic differentiation potential (Shao et al, 2015). Accumulating body of studies have shown that scaffold supplemented with MSCs derived from bone marrow promote bone regeneration and have superior healing effects in bone fracture (Shao et al, 2015).…”

Section: Msc In Applied Bone Regenerationmentioning

confidence: 99%

“…Nevertheless, MSCs derived from bone marrow are the best candidate for bone engineering, as compared with other MSCs sources, mainly through the highly chondrogenic differentiation potential (Shao et al, ). Accumulating body of studies have shown that scaffold supplemented with MSCs derived from bone marrow promote bone regeneration and have superior healing effects in bone fracture (Shao et al, ). Additionally, implanted scaffold without MSCs had no such impact (Agacayak, Gulsun, Ucan, Karaoz, & Nergiz, ).…”

Section: Introductionmentioning

confidence: 99%

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The roles of signaling pathways in bone repair and regeneration

Majidinia

Sadeghpour

Yousefi

2017

Journal Cellular Physiology

328

261

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Regenerative medicine has sparked interest in potential strategies for bone repair. Bone defects are widespread and could be caused by trauma, congenital malformations, infections, and surgery. Although bone has a large self-healing capacity, some defects or fractures are too big to regenerate. To regenerate bone structures which can be used for treatment of patients, bone growth must be induced by a number of bioactive implantable materials, cell types and intracellular, and extracellular molecular signaling pathways. Since mesenchymal stem cells (MSCs) and their differentiation during remodeling processes have important roles in bone regeneration, it is believed that understanding molecular signaling pathways involved is crucial to the development of bone implants, bone substitute materials, and cell-based scaffolds for bone regeneration. In this review, we briefly introduce concepts in fracture repair and regeneration following bone injuries, and then discuss the current clinical methods in bone regeneration. In the next section, we review the involvement of the various key signaling pathways in bone regeneration.

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Section: Msc In Applied Bone Regenerationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The roles of signaling pathways in bone repair and regeneration

Majidinia

Sadeghpour

Yousefi

2017

Journal Cellular Physiology

328

261

View full text Add to dashboard Cite

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“…Furthermore, secretion of angiogenic factors in injured tissue could be due to the activation of HIFs [Mallela et al, 2013]. MSCs can also recruit the other MSCs or progenitor cells towards the injury/defect site via paracrine effects [Shao et al, 2015]. Some studies have focused on the recruitment of MSCs to the bone defect site for treating the nonunions.…”

Section: Msc Homing and Recruitment To Bone Defectsmentioning

confidence: 99%

Role of Mesenchymal Stem Cells in Bone Regenerative Medicine: What Is the Evidence?

Oryan

Kamali²,

Moshiri³

et al. 2017

Cells Tissues Organs

273

204

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Healing and regeneration of bone injuries, particularly those that are associated with large bone defects, are a complicated process. There is growing interest in the application of osteoinductive and osteogenic growth factors and mesenchymal stem cells (MSCs) in order to significantly improve bone repair and regeneration. MSCs are multipotent stromal stem cells that can be harvested from many different sources and differentiated into a variety of cell types, such as preosteogenic chondroblasts and osteoblasts. The effectiveness of MSC therapy is dependent on several factors, including the differentiating state of the MSCs at the time of application, the method of their delivery, the concentration of MSCs per injection, the vehicle used, and the nature and extent of injury, for example. Tissue engineering and regenerative medicine, together with genetic engineering and gene therapy, are advanced options that may have the potential to improve the outcome of cell therapy. Although several in vitro and in vivo investigations have suggested the potential roles of MSCs in bone repair and regeneration, the mechanism of MSC therapy in bone repair has not been fully elucidated, the efficacy of MSC therapy has not been strongly proven in clinical trials, and several controversies exist, making it difficult to draw conclusions from the results. In this review, we update the recent advances in the mechanisms of MSC action and the delivery approaches in bone regenerative medicine. We will also review the most recent clinical trials to find out how MSCs may be beneficial for treating bone defects.

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“…This problem is more severe in patients with hypothyroidism. MSC is an appropriate candidate for bone regeneration (43). Although, clinical application of MSCs have shown beneficial effects in the treatment of various diseases, implanted MSCs do not survive for long after transplantation (44).…”

Section: Discussionmentioning

confidence: 99%

Adipose Derived Stem Cells Conditioned Media in Combination with Bioceramic-Collagen Scaffolds Improved Calvarial Bone Healing in Hypothyroid Rats

Sanchooli

Norouzian

Ardeshirylajimi

et al. 2017

Iran Red Crescent Med J

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Background: Tissue engineering is an available treatment for large bone defects. The therapeutic effects of mesenchymal stem cell (MSC) are mostly attributed to secretion of many cytokines and growth factors. Many factors of MSC secretions accumulate in a conditioned medium and these factors recruit native cells into a defect site to generate new bone tissues. Objectives: The aim of this study was to evaluate the influence of adipose tissue derived MSCs-conditioned medium (ADMSC-CM) on bone repair of rats with critical -size calvarial defect. Methods: This experimental study was performed at Shahid Beheshti University of Medical Sciences, Tehran, Iran, from 2016 to 2017. Conditioned medium was collected from healthy rat adipose tissue derived MSC (ADMSC) at passage four. Calvarial bone defect was created in hypothyroid rats using a dental bur. Sampling was taken by the linear-mono-gram method to determine sample size (n = 6 per group). The rats were divided randomly into four groups based on graft material as follows: empty defect, scaffold (Bio-Oss / type I collagen gel), scaffold / ADMSCs, scaffold /ADMSC-CM. Evaluations were made at 4 and 8 weeks after surgery using stereological analysis. Results: Histological analysis at 8 weeks indicated that the newly regenerated tissue almost covered the defect in the ADMSC-CM group. Stereological analysis showed that ADMSC-CM increased regenerated bone and numbers of osteocytes and osteoblasts compared with the defect and scaffold groups (P < 0.05). Also, bone regeneration was more effective in animals treated with ADMSC-CM than in those received ADMSC. Conclusions: These results suggest an important role for ADMSC-CM in bone regeneration, through trophic impact of its cytokines and growth factors that induce native cell proliferation and migration into the defect. Thus, ADMSC-CM seems to have good potential for application in bone tissue regeneration, in the cases of hypothyroidism.

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Using mesenchymal stem cells as a therapy for bone regeneration and repairing

Cited by 71 publications

References 85 publications

The roles of signaling pathways in bone repair and regeneration

The roles of signaling pathways in bone repair and regeneration

Role of Mesenchymal Stem Cells in Bone Regenerative Medicine: What Is the Evidence?

Adipose Derived Stem Cells Conditioned Media in Combination with Bioceramic-Collagen Scaffolds Improved Calvarial Bone Healing in Hypothyroid Rats

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