The advent of machine learning technologies has ushered in a transformative phase for telemarketing, particularly in the domain of audience targeting. This comprehensive research undertakes a meticulous examination of various machine learning algorithms, delineating their roles and efficacy within the telemarketing paradigm. Delving deep into their applications for audience targeting, the study juxtaposes machine learning approaches with traditional marketing strategies, elucidating nuances that inform their respective merits and challenges. As the assessment unfolds, it sheds light on the inherent benefits and potential pitfalls of each algorithmic approach, providing a robust analytical framework for practitioners and scholars alike. Furthermore, in acknowledging the contemporary challenges, the study extensively addresses potential risks, underpinning ethical dilemmas, and methodological limitations that are intrinsic to the integration of advanced computational techniques in marketing. Drawing its conclusions, the research not only encapsulates the current state of affairs but also charts out avenues for prospective investigations. By weaving a narrative that seamlessly combines theoretical postulates with practical implications, this document stands as a beacon for those navigating the intricate corridors of machine learning's role in modern-day telemarketing strategies.