Abstract:The pneumococcal conjugate vaccines (PCVs) protect against diseases caused by Streptococcus pneumoniae, such as meningitis, bacteremia, and pneumonia. It is challenging to estimate their population-level impact due to the lack of a perfect control population and the subtleness of signals when the endpoint – like all-cause pneumonia – is non-specific. Here we present a new approach to estimate PCVs’ impact – using LASSO regression to predict the counterfactual outcome for vaccine impact inference. We first used… Show more
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