Using larval therapy in the community setting

Rafter, Linda

doi:10.12968/bjcn.2013.18.sup12.s20

Cited by 7 publications

(6 citation statements)

References 23 publications

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“…50 Therefore, one of the most important advantages of MDT is that maggots facilitate surgical debridement by separating necrotic tissue from healthy tissue easily and effectively with minimal tissue trauma. 51,52 On the contrary, MDT provides a precise, accurate and sensitive debridement without harming bones, tendons or healthy tissue. 44,53,54 Maggots with their antimicrobial properties can also inhibit microorganisms, providing an effect that cannot be achieved in the surgical debridement procedure.…”

Section: General Overview Of Mdt and Conventional Debridement Methodsmentioning

confidence: 99%

“…Because it is difficult to separate the necrotic tissue or poorly perfused tissue from the healthy tissue 50 . Therefore, one of the most important advantages of MDT is that maggots facilitate surgical debridement by separating necrotic tissue from healthy tissue easily and effectively with minimal tissue trauma 51,52 . On the contrary, MDT provides a precise, accurate and sensitive debridement without harming bones, tendons or healthy tissue 44,53,54 .…”

Section: General Overview Of Mdt and Conventional Debridement Methodsmentioning

confidence: 99%

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A molecular approach to maggot debridement therapy with Lucilia sericata and its excretions/secretions in wound healing

Tombultürk

Kanıgür-Sultuybek

2021

Wound Repair Regeneration

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Chronic wounds caused by underlying physiological causes such as diabetic wounds, pressure ulcers, venous leg ulcers and infected wounds affect a significant portion of the population. In order to treat chronic wounds, a strong debridement, removal of necrotic tissue, elimination of infection and stimulation of granulation tissue are required. Maggot debridement therapy (MDT), which is an alternative treatment method based on history, has been used quite widely. MDT is an efficient, simple, cost-effective and reliable biosurgery method using mostly larvae of Lucilia sericata fly species. Larvae can both physically remove necrotic tissue from the wound site and stimulate wound healing by activating molecular processes in the wound area through the enzymes they secrete. The larvae can stimulate wound healing by activating molecular processes in the wound area through enzymes in their excretions/ secretions (ES). Studies have shown that ES has antibacterial, antifungal, anti-inflammatory, angiogenic, proliferative, hemostatic and tissue-regenerating effects both in vivo and in vitro. It is suggested that these effects stimulate wound healing and accelerate wound healing by initiating a direct signal cascade with cells in the wound area. However, the enzymes and peptides in ES are mostly still undefined. Examining the molecular content of ES and the biological effects of these ingredients is quite important to illuminate the molecular mechanism underlying MDT. More importantly, ES has the potential to have positive effects on wound healing and to be used more as a therapeutic agent in the future, so it can be applied as an alternative to MDT in wound healing.

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Section: General Overview Of Mdt and Conventional Debridement Methodsmentioning

confidence: 99%

Section: General Overview Of Mdt and Conventional Debridement Methodsmentioning

confidence: 99%

A molecular approach to maggot debridement therapy with Lucilia sericata and its excretions/secretions in wound healing

Tombultürk

Kanıgür-Sultuybek

2021

Wound Repair Regeneration

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“…MDT has been used in many cultures for the treatment of infections and the practice goes back to ancient time [3]. MDT was replaced with antibiotics once they became available in 1928.…”

Section: Introductionmentioning

confidence: 99%

A Case Report of the At-Home Application of Maggot in Treatment of Infected Wound in A Diabetic Patient

Yousefipour¹

2017

IJCAM

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Use of sterile maggot larvae in the removal of infected tissue has been practiced for centuries in different cultures. The practice was declined once antibiotics were introduced. Today, due to antibiotic resistant development or when conventional treatment is not possible, use of maggot therapy in management of infection in different conditions has been shown to be effective. Maggot therapy has been reported to be especially effective in treating diabetic wounds once it starts early in the process.Here, we are reporting a case study where maggot therapy was applied by a family member at home to an elderly patient when two months treatment of a wound in a diabetic foot with conventional antibiotics showed no improvement in progression of healing. However, addition of maggot therapy at home was effective in complete healing of the wound in three months. Our observations indicate a decrease in exudation and edema a week after the application of maggot therapy, significant improvement three weeks after, and a complete healing after three months of maggot therapy.Based on these observations we are concluding that maggot therapy can be safely applied by an untrained person at home setting. This is a low cost and convenient alternative to antibiotic treatment that can be used at home for treating diabetic wounds without the need of a professional.

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“…This method efficiently removes the necrotic tissue without damaging healthy cells, while decreasing the bacterial load and promoting tissue regeneration in some types of chronic wounds . These factors have contributed to an upsurge of MDT usage to augment conventional medical treatments all over the world . While universal acceptance and use of MDT is currently unlikely due to its limitations, the proven efficacy of the treatment coupled with advancement of larval rearing and application techniques suggest continued increase in use of this therapy …”

mentioning

confidence: 99%

“…These factors have contributed to an upsurge of MDT usage to augment conventional medical treatments all over the world . While universal acceptance and use of MDT is currently unlikely due to its limitations, the proven efficacy of the treatment coupled with advancement of larval rearing and application techniques suggest continued increase in use of this therapy …”

mentioning

confidence: 99%

Methods for external disinfection of blow fly (Diptera: Calliphoridae) eggs prior to use in wound debridement therapy

Brundage

Crippen

Tomberlin

2016

Wound Repair Regeneration

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Maggot debridement therapy (MDT) is the use of the larval stage of flies (i.e., Calliphoridae) to remove necrotic tissue and disinfect wounds. Effective MDT requires aseptic technique to prevent the unintentional introduction of pathogenic bacteria into a wound to be debrided; yet the external surface of Calliphoridae eggs is often heavily contaminated with bacteria. Studies of external disinfection of dipteran eggs have been reported, but neither their efficacy nor effect on egg viability has been adequately assessed. The present study evaluated the efficacy of ten disinfection techniques involving immersion, rinse, or a combination of both in formalin, Lysol, formaldehyde, bleach, ethanol, Sporgon, or benzalkonium chloride. All techniques resulted in significant decreases in culturable, aerobic bacterial load on Lucilia cuprina eggs. For L. cuprina, a 10 minute 3% Lysol immersion was the most efficacious, disinfecting 96.67% of egg samples, while resulting in 31.84% egg mortality. The 5% formalin immersion was least efficacious, disinfecting only 3.33% of L. cuprina egg samples, while resulting in 33.51% egg mortality. A formaldehyde immersion, one of the most commonly used disinfection techniques, was moderately effective, disinfecting 66.7% of egg samples, while resulting in 40.16% egg mortality. For Chrysomya rufifacies and Cochliomyia macellaria egg samples, the 10 minute 3% Lysol immersion disinfected 100% of the samples, and for Lucilia sericata, 80% of egg samples, while resulting in 33.97%, 7.34%, and 36.96% egg mortality, respectively. H2 CO disinfected 16.67% of Ch. rufifacies, 26.67% of C. macellaria, and 56.67% of L. sericata egg samples, while resulting in 21.98%, 10.18%, and 32.19% egg mortality, respectively. Due to its high disinfection efficacy and relatively low egg mortality, a 10 minutes 3% Lysol immersion is recommended for sterilizing Calliphoridae eggs prior to rearing of larvae for use in MDT.

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Using larval therapy in the community setting

Cited by 7 publications

References 23 publications

A molecular approach to maggot debridement therapy with Lucilia sericata and its excretions/secretions in wound healing

A molecular approach to maggot debridement therapy with Lucilia sericata and its excretions/secretions in wound healing

A Case Report of the At-Home Application of Maggot in Treatment of Infected Wound in A Diabetic Patient

Methods for external disinfection of blow fly (Diptera: Calliphoridae) eggs prior to use in wound debridement therapy

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