Using laboratory parameters as predictors for the severity and mortality of COVID-19 in hospitalized patients

Al-Shajlawi, Mustafa; Alsayed, Ahmad R.; Abazid, Husam; Awajan, Dima; Al-Imam, Amniyah; Basheti, Iman A.

doi:10.18549/pharmpract.2022.3.2721

Cited by 5 publications

(11 citation statements)

References 19 publications

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“…Multiple studies conducted on hospitalized COVID-19 patients have revealed a median age ranging between 49 and 56 years [ 3 , 7 , 8 ]. Additionally, older age has been associated with increased mortality rates [ 2 , 6 , 33 , 34 ].…”

Section: Risk Factors For Covid-19-associated Hospitalizationmentioning

confidence: 99%

“…A recent retrospective study conducted in Jordan aimed to investigate the correlation between the initial laboratory parameters of hospitalized COVID-19 patients and the incidence of severity and mortality [ 6 ]. A significant statistical correlation was observed between exceeding certain laboratory parameters’ cut-off values and the severity or mortality of the condition.…”

Section: Laboratory Findings Of Covid-19 Patientsmentioning

confidence: 99%

“…The observed laboratory findings encompassed elevated levels of D-dimer, liver enzymes, lactate dehydrogenase (LDH), C-reactive protein (CRP), ferritin, prothrombin time (PT), and troponin. Conversely, decreased levels of lymphocyte and platelet counts were also noted [ 4 , 6 , 9–11 ]. A study conducted in China involving 138 hospitalized patients revealed that individuals who did not survive exhibited a progressive decrease in lymphocyte count and an increase in D-dimer levels over time.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, socioeconomic status, diet, lifestyle, geographical location, ethnicity, exposed viral load, timing of treatment initiation, and healthcare quality have all been shown to influence individual outcomes. Studies indicate that elevated levels of CRP and radiographic evidence upon admission are correlated with COVID-19 pneumonia, entry into the intensive care unit (ICU), and mortality rates [ 6 , 12–16 ].…”

Section: Introductionmentioning

confidence: 99%

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The laboratory parameters in predicting the severity and death of COVID-19 patients: Future pandemic readiness strategies

Alsayed,

Ahmed,

AL Shweiki

et al. 2024

Biomol Biomed

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The range of clinical manifestations associated with the infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encompasses a broad spectrum, ranging from flu-like symptoms to the occurrence of multiple organ failure and death. The severity of the coronavirus disease 2019 (COVID-19) is categorized based on clinical presentation and is divided into three distinct levels of severity identified as non-severe, severe, and critical. Although individuals of all age groups are susceptible to SARS-CoV-2 infection, middle-aged and older adults are more frequently impacted, with the latter being more likely to develop severe illness. Various laboratory characteristics observed in hospitalized COVID-19 patients have been correlated with adverse outcomes. These include elevated levels of D-dimer, liver enzymes, lactate dehydrogenase, C-reactive protein, ferritin, prothrombin time, and troponin, as well as decreased lymphocyte and platelets counts. This review investigated the relationship between baseline clinical characteristics, initial laboratory parameters upon hospital admission, and the severity of illness and mortality rates among COVID-19 patients. Although the COVID-19 pandemic has concluded, understanding the laboratory predictors of virus severity and mortality remains crucial, and examining these predictors can have long-term effects. Such insights can help healthcare systems manage resources more effectively and deliver timely and appropriate care by identifying and targeting high-risk individuals. This knowledge can also help us better prepare for future pandemics. By examining these predictors, we can take steps to protect public health and mitigate the impact of future pandemics.

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Section: Risk Factors For Covid-19-associated Hospitalizationmentioning

confidence: 99%

Section: Laboratory Findings Of Covid-19 Patientsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The laboratory parameters in predicting the severity and death of COVID-19 patients: Future pandemic readiness strategies

Alsayed,

Ahmed,

AL Shweiki

et al. 2024

Biomol Biomed

View full text Add to dashboard Cite

show abstract

“…In addition, socioeconomic status, diet, lifestyle, geographical differences, ethnicity, exposed viral load, day of initiation of treatment, and quality of health care have all been reported to influence individual outcomes. Furthermore, higher CRP and radiography findings at admission are associated with COVID-19 pneumonia, intensive care unit admission, and death [8][9][10][11][12].…”

Section: Covid-19 (Coronavirus Diseasementioning

confidence: 99%

Importance of Demographic and Clinical Features in Evaluating the Severity of COVID-19 in Hospitalized Patients: A Serbian Retrospective Study in the First Pandemic Year

Aritonovic Pribakovic,

Peric,

Milenkovic

et al. 2023

JCM

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The aim of this study is to determine the demographic and initial clinical characteristics of patients with COVID-19 and their importance in evaluating the severity of the disease. A retrospective study included patients suffering from COVID-19 who were hospitalized at The Department of Infectious Disease of the Clinical Hospital Center Pristina—Gracanica from the beginning of the pandemic until the end of 2020. We compared the symptoms of the disease, radiographic findings of pneumonia, laboratory parameters, duration of symptoms before admission, the difference in the need for certain therapies, and the presence of comorbidities between non-severe and severe groups of patients. Patients with a severe disease were statistically significantly older. Hypertension was significantly associated with severe clinical conditions. Radiographic findings of bilateral pneumonia on admission were much more frequent among the severe group, and these patients’ need for oxygen support was significantly higher. Lower neutrophil and higher lymphocyte counts were statistically significant in the non-severe group. Biochemical parameters at admission also showed statistical significance between the examined groups. Based on our research, we can conclude that a complete overview of the patient, including demographic and laboratory parameters as perhaps the most significant attributes, can help doctors in the timely clinical assessment of patients and, thus, in the timely application of adequate therapeutic protocols in the treatment of COVID-19.

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Albumin Is a Component of the Esterase Status of Human Blood Plasma

Belinskaia

Voronina

Попова

et al. 2023

IJMS

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The esterase status of blood plasma can claim to be one of the universal markers of various diseases; therefore, it deserves attention when searching for markers of the severity of COVID-19 and other infectious and non-infectious pathologies. When analyzing the esterase status of blood plasma, the esterase activity of serum albumin, which is the major protein in the blood of mammals, should not be ignored. The purpose of this study is to expand understanding of the esterase status of blood plasma and to evaluate the relationship of the esterase status, which includes information on the amount and enzymatic activity of human serum albumin (HSA), with other biochemical parameters of human blood, using the example of surviving and deceased patients with confirmed COVID-19. In experiments in vitro and in silico, the activity of human plasma and pure HSA towards various substrates was studied, and the effect of various inhibitors on this activity was tested. Then, a comparative analysis of the esterase status and a number of basic biochemical parameters of the blood plasma of healthy subjects and patients with confirmed COVID-19 was performed. Statistically significant differences have been found in esterase status and biochemical indices (including albumin levels) between healthy subjects and patients with COVID-19, as well as between surviving and deceased patients. Additional evidence has been obtained for the importance of albumin as a diagnostic marker. Of particular interest is a new index, [Urea] × [MDA] × 1000/(BChEb × [ALB]), which in the group of deceased patients was 10 times higher than in the group of survivors and 26 times higher than the value in the group of apparently healthy elderly subjects.

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Using laboratory parameters as predictors for the severity and mortality of COVID-19 in hospitalized patients

Cited by 5 publications

References 19 publications

The laboratory parameters in predicting the severity and death of COVID-19 patients: Future pandemic readiness strategies

The laboratory parameters in predicting the severity and death of COVID-19 patients: Future pandemic readiness strategies

Importance of Demographic and Clinical Features in Evaluating the Severity of COVID-19 in Hospitalized Patients: A Serbian Retrospective Study in the First Pandemic Year

Albumin Is a Component of the Esterase Status of Human Blood Plasma

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