Using Intranasal Midazolam Spray to Prevent Claustrophobia Induced by MR  Imaging

Hollenhorst, Josef; Münte, Sinikka; Friedrich, Lars; Heine, J.; Leuwer, Martin; Becker, H.; Piepenbrock, S.

doi:10.2214/ajr.176.4.1760865

Cited by 64 publications

(63 citation statements)

References 16 publications

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“…It can only eliminate some factors which affect the effects of examination with routine nursing to the claustrophobics [4]. The unhealthy psychological status for patients like anxiety and panic cannot be improved.…”

Section: Discussionmentioning

confidence: 99%

The Effectiveness of Nursing Intervention for Patients with Claustrophobia in MR Examination

Dong¹,

Zhao²,

Deng³

2017

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Objective: To evaluate the effectiveness of a nursing intervention for patients with claustrophobia in MR examination. Methods: This study included 40 claustrophobic patients who underwent MR examination from March 2013 to May 2015 in our hospital. These patients were randomly divided into two groups; each group had 20 patients. Among them, usual care was taken in one group (control group) and nursing intervention was added on the basis of usual care in another group (observation group). The patient's psychological state and MR successful rate were compared between these two groups. Results: In control group and observation group, the scores of anxiety were 46.20 ± 3.07, 37.50 ± 2.54, respectively. The scores of depression were 44.30 ± 2.54, 37.70 ± 2.15. MR successful rates were 35.00% and 90.00%, respectively. There were significant differences in these two groups (P < 0.05). Conclusion: Effective nursing interventions can improve patient's psychological state and MR successful rate for claustrophobic patients.

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Section: Discussionmentioning

confidence: 99%

The Effectiveness of Nursing Intervention for Patients with Claustrophobia in MR Examination

Dong¹,

Zhao²,

Deng³

2017

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“…(39) Up to 37% of patients who undergo MRI experience moderate to severe fear and anxiety, and 5-10% of patients cannot complete the MRI session because of claustrophobia. (39) Patient cooperation is a necessary condition for the examination because motion artifacts generally degrade the quality and diagnostic value of MRI. Prolonged scanning with additional sequences, sedation, or general anesthesia is required in order to complete the procedure in claustrophobic patients.…”

Section: Final Considerationsmentioning

confidence: 99%

“…This can result in a waste of valuable scan time and increased scanning costs. (39) The cost of imaging studies is an important consideration. Because of the complexity of the imaging system, together with the intrinsic maintenance costs, MRI is inevitably a more expensive test than is CT.…”

Section: Final Considerationsmentioning

confidence: 99%

Ressonância magnética de pulmão: um novo passo no estudo das doenças pulmonares

et al. 2012

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Magnetic resonance imaging (MRI) of the lung has progressed tremendously in recent years. Because of improvements in speed and image quality, MRI is now ready for routine clinical use. The main advantage of MRI of the lung is its unique combination of structural and functional assessment in a single imaging session. We review the three major clinical indications for MRI of the lung: staging of lung tumors; evaluation of pulmonary vascular disease; and investigation of pulmonary abnormalities in patients who should not be exposed to radiation.Keywords: Magnetic resonance imaging; Lung; Lung diseases; Carcinoma, non-small-cell lung; Lung diseases, interstitial; Pneumonia. ResumoA ressonância magnética (RM) de pulmão progrediu tremendamente nos últimos anos. Devido a melhorias na velocidade e na qualidade de imagens, a RM de pulmão hoje está pronta para a utilização clínica de rotina. A principal vantagem da RM de pulmão é a sua combinação exclusiva de avaliação estrutural e funcional em uma única sessão de imagens. Revisamos aqui as três principais indicações clínicas da RM de pulmão: o estadiamento de tumores pulmonares, a avaliação de doença vascular pulmonar e a investigação de anormalidades pulmonares em pacientes que não podem ser expostos à radiação.Descritores: Imagem por ressonância magnética; Pulmão; Pneumopatias; Carcinoma pulmonar de células não pequenas; Doenças pulmonares intersticiais; Pneumonia.

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“…According to the literature, up to 10% of all MR examinations cannot be completed or even started because of claustrophobia (1,2). In clinical practice, midazolam or other benzodiazepines are frequently used intravenously, orally, sublingually, or intrarectally for medical sedation and anxiolysis in order to enable MRI of claustrophobic patients.…”

mentioning

confidence: 99%

“…A limited number of studies (2,4,5) have shown the potential of nasally administrated midazolam for reduction of anxiety-related claustrophobia in patients undergoing MR imaging. However, all these studies were single-center studies with a limited number of patients.…”

mentioning

confidence: 99%

Multicenter trial: Comparison of two different formulations and application systems of low‐dose nasal midazolam for routine magnetic resonance imaging of claustrophobic patients

Tschirch

Suter

Froehlich³

et al. 2008

Magnetic Resonance Imaging

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Purpose:To prospectively assess and compare two formulations and methods of administration of low-dose nasal midazolam for the treatment of claustrophobic patients undergoing magnetic resonance imaging (MRI) as part of a multicenter Phase III trial. Materials and Methods:In all, 108 consecutive adult claustrophobic patients were randomly assigned to one of two treatment groups (multidose group: MDG, unit-dose group: UDG). MDG encompassed 55 patients who received intranasally a 0.5% midazolam formulation into each nostril (total dose, 1.0 mg), whereas the 53 patients in UDG received a 1% midazolam formulation into only one nostril (total dose, 1.0 mg). This initial dose could be repeated once. Patient tolerance and anxiety were assessed using a questionnaire and a visual analog scale immediately before and after MRI. Image quality was evaluated using a fivepoint scale.Results: In all, 53/55 MR examinations (96%) with MDG and 52/53 (98%) with UDG were completed successfully. The dose of 1 mg had to be repeated significantly less often in UDG compared to MDG (4/53, 8% vs. 13/55, 24%; P ϭ 0.003). The image quality of all MR examinations was rated good to excellent, and slightly better in UDG (P ϭ 0.045).Conclusion: Nasally applied low-dose midazolam is a patient-friendly solution to facilitate MRI of claustrophobicpatients. The nasal spray of UDG is superior to that of MDG with a necessity of additional dosing.

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Using Intranasal Midazolam Spray to Prevent Claustrophobia Induced by MR Imaging

Cited by 64 publications

References 16 publications

The Effectiveness of Nursing Intervention for Patients with Claustrophobia in MR Examination

The Effectiveness of Nursing Intervention for Patients with Claustrophobia in MR Examination

Ressonância magnética de pulmão: um novo passo no estudo das doenças pulmonares

Multicenter trial: Comparison of two different formulations and application systems of low‐dose nasal midazolam for routine magnetic resonance imaging of claustrophobic patients

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