Using injectable carriers of laser-polarized noble gases for enhancing NMR and MRI

Temperature‐Controlled Molecular Depolarization Gates in Nuclear Magnetic Resonance

“…Amplifying the available magnetization has been the focus of many studies, leading to various hyperpolarization (hp) techniques such as hp noble gases (1,2), para-hydrogen induced polarization transfer (3,4), or dynamic nuclear polarization (5). Exploiting chemical exchange of nuclei of a hyperpolarized reservoir in combination with a mechanism of gated transfer onto the molecule of interest would provide optimized, controlled 'utilization' of the hyperpolarization (Fig 1a), hence avoiding polarization losses during transfer reactions.…”

Xenon‐129 MR imaging and spectroscopy of rat brain using arterial delivery of hyperpolarized xenon in a lipid emulsion

“…For instance, the catheter dead volume could be reduced and the delivery rate as well, although this would require further signal enhancement. Using Intralipid 30% degassed to remove paramagnetic oxygen from the solution, longer xenon T 1 relaxation times could result (1). Degassing could also help in reducing SNR variability.…”

Configuration and Performance of a Mobile 129Xe Polarizer

“…The polarizability of its electron shell accounts for a millimolar solubility in aqueous solution with chemical shift sensitivity to the microscopic or molecular environment higher than 200 ppm [12], as well as for a stable binding via dispersion forces to molecular host structures [13]. Accordingly, applications of dissolved hyperpolarized 129 Xe range from the investigation of protein structure and dynamics in vitro [14] to in vivo studies of blood flow and tissue perfusion in animals [15] as well as in humans [10]. Also, specifically functionalized molecular cages have been designed to house xenon with the prospect to develop highly specific and sensitive NMR probes for bio-analytics or contrast agents for clinical imaging [16].…”