As nations transition to renewable energy, making use of waste heat becomes crucial to combat climate change. This study focused on quantifying Switzerland’s waste heat potential from industrial processes and waste-to-energy facilities, using diverse methodologies tailored to facility characteristics and data availability. We assessed potential waste heat utilization by comparing local heat supply and demand, creating comprehensive heat-balance maps considering different temperature levels and seasonal fluctuations. Results revealed a substantial annual waste heat potential of 37 TWh, with almost half (17 TWh) below 45 °C, primarily from wastewater. Heat between 45 °C and 70 °C, ideal, e.g., for greenhouse heating, is mainly available from solid waste incineration plants, while industries contributed to waste heat supply exceeding 150 °C. In contrast to heat demand, seasonal variations in heat supply were small, with a 12% winter decrease. Analyzing heat demand versus supply unveiled local and seasonal disparities. Most municipalities had a net excess heat demand (totaling 89 TWh). Additionally, waste heat could not satisfy 8 TWh of industrial process heat demand exceeding 400 °C, emphasizing reliance on primary energy sources for higher-temperature heat. Targeted strategies are essential for effective waste heat utilization, especially tapping into low-temperature sources. Integrating these sources with low-carbon technologies can pave the way to a sustainable energy future.