Using in silico methods to determine optimal tapering regimens for decanoate-based long-acting injectable psychosis drugs
James R. O’Neill,
David M. Taylor,
Mark A. Horowitz
Abstract:Background: Reducing the dose of psychosis drugs in a gradual hyperbolic manner may minimise withdrawal effects and risk of relapse. There is presently limited guidance on tapering decanoate-based long-acting injectable dopamine antagonists (LIDAs). Objectives: We aimed to apply hyperbolic principles of tapering to the decanoate-based LIDAs flupentixol, zuclopenthixol and haloperidol to develop withdrawal regimens. Design: We used in silico methodology to predict plasma drug levels and D2 occupancy for differe… Show more
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