Using Imagination to Integrate Contextual Effects in a Cue-Reactivity Paradigm in Patients with Alcohol Use Disorder: A Functional Magnetic Resonance Imaging Pilot Study

Abstract

<b><i>Introduction:</i></b> In individuals with alcohol use disorder (AUD), the brain areas underlying cue-induced reactions (e.g., cingulum, striatum, thalamus) and altered activation of these regions have been identified by functional neuroimaging. Neuronal responses to a complex alcohol-related context are yet to investigate. To better understand contextual effects as well as the interplay of cue-induced neural reactions and context exposure, the present study implemented an imagination procedure during functional magnetic resonance imaging (fMRI). <b><i>Methods:</i></b> Thirteen patients with AUD and 13 healthy controls completed two rounds of a cue-reactivity paradigm inside an MRI scanner. Two individualized imagination tasks were conducted before each of the two cue reactivity tasks. A 2 (group) × 2 (imagination) × 2 (picture-type) analysis of variance (ANOVA) was performed. <b><i>Results:</i></b> The ANOVA revealed a main effect for imagination with higher activation in bilateral thalamus and right caudate nucleus and an interaction effect between imagination and group in right thalamus and left caudate nucleus, due to the patient group reacting stronger during alcohol-related imagination. These structures are involved in relaying sensory information and habit learning. No main or interaction effects of picture type were observed. <b><i>Conclusions:</i></b> These results support the view that context effects alter the neural responses in thalamus and nucleus caudatus in patients with AUD, and that imagination tasks are suited to incorporate contextual influences in neurophysiological research designs. Future research needs to investigate whether the failure to observe a picture-type effect was due to limited statistical power and omission to individualize picture set, or whether an imagination procedure interferes with the evocation of picture-type effects.

Targeting Learning Mechanisms in Addictive Disorders

“…Mechanisms and functions of goal-directed versus habitual behavior are discussed by Doñamayor et al [9] with a focus on contextual and personal factors. Adding to this line of research, Fey et al [10] examine the biological correlates of the interaction of the imagination of individual drinking situations and alcohol-related stimuli to address the influence of drinking context on cue reactivity. The effect of Pavlovian conditioned cues on instrumental behavior can be assessed using Pavlovian-to-Instrumental Transfer (PIT) paradigms, which are discussed with respect to drug-related findings by Garbusow et al [11].…”