Using<i>Fomitopsis pinicola</i>for bioinspired synthesis of titanium dioxide and silver nanoparticles, targeting biomedical applications

The current study demonstrates the synthesis of fatty acids (FAs) capped silver nanoparticles (AgNPs) using aqueous poly-herbal drug Liv52 extract (PLE) as a reducing, dispersing and stabilizing agent. The NPs were characterized by various techniques and used to investigate their potent antibacterial, antibiofilm, antifungal and anticancer activities. GC-MS analysis of PLE shows a total of 37 peaks for a variety of bio-actives compounds. Amongst them, n-hexadecanoic acid (21.95%), linoleic acid (20.45%), oleic acid (18.01%) and stearic acid (13.99%) were found predominately and most likely acted as reducing, stabilizing and encapsulation FAs in LIV-AgNPs formation. FTIR analysis of LIV-AgNPs shows some other functional bio-actives like proteins, sugars and alkenes in the soft PLE corona. The zone of inhibition was 10.0 ± 2.2–18.5 ± 1.0 mm, 10.5 ± 2.5–22.5 ± 1.5 mm and 13.7 ± 1.0–16.5 ± 1.2 against P. aeruginosa, S. aureus and C. albicans, respectively. LIV-AgNPs inhibit biofilm formation in a dose-dependent manner i.e., 54.4% ± 3.1%—10.12% ± 2.3% (S. aureus), 72.7% ± 2.2%–23.3% ± 5.2% (P. aeruginosa) and 85.4% ± 3.3%–25.6% ± 2.2% (C. albicans), and SEM analysis of treated planktonic cells and their biofilm biomass validated the fitness of LIV-AgNPs in future nanoantibiotics. In addition, as prepared FAs rich PLE capped AgNPs have also exhibited significant (p < 0.05 *) antiproliferative activity against cultured HCT-116 cells. Overall, this is a very first demonstration on employment of FAs rich PLE for the synthesis of highly dispersible, stable and uniform sized AgNPs and their antibacterial, antifungal, antibiofilm and anticancer efficacy.

show abstract

“…CCL-247) cell line was used. Both, the microbial and human carcinoma cell cultures were maintained as described in earlier studies [ 9 , 58 ].…”

Section: Methodsmentioning

confidence: 99%

Biofabricated Fatty Acids-Capped Silver Nanoparticles as Potential Antibacterial, Antifungal, Antibiofilm and Anticancer Agents

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Data from these surveillance systems could be used to target intervention strategies as well as develop and promote antimicrobial stewardship programs [ 14 , 85 , 86 ]. There are emerging natural and nanoparticle-based antimicrobial therapies [ [87] , [88] , [89] ] but global partnerships are required for their development. Vaccines offer the potential to reduce demand for antimicrobials and slow the spread of AMR [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

The interrelationships between antimicrobial resistance, COVID-19, past, and future pandemics

Ukuhor¹

2021

Journal of Infection and Public Health

View full text Add to dashboard Cite

“…Over 1800 species of fungi are found in this division. Academic theoretic investigations on intracellular manufacturing are possible (Rehman et al, 2020b).…”

Section: Advantages Of Using Fungi In Nanoparticle Synthesismentioning

confidence: 99%

Development of micro/nanostructured‒based biomaterials with biomedical applications

ALHARTHI

2023

Biocell

View full text Add to dashboard Cite

Natural biomaterials are now frequently used to build biocarrier systems, which can carry medications and biomolecules to a target region and achieve a desired therapeutic effect. Biomaterials and polymers are of great importance in the synthesis of nanomaterials. The recent studies have tended to use these materials because they are easily obtained from natural sources such as fungi, algae, bacteria, and medicinal plants. They are also biodegradable, compatible with neighborhoods, and non-toxic. Natural biomaterials and polymers are chemically changed when they are linked by cross linking agents with other polymers to create scaffolds, matrices, composites, and interpenetrating polymer networks employing microtechnology and nanotechnology. This review highlights how microengineered and nanoengineered biomaterials are utilized to produce efficient drug-delivery systems and biomedical and biological therapies and how innovative sources of biomaterials have been identified.

show abstract

UsingFomitopsis pinicolafor bioinspired synthesis of titanium dioxide and silver nanoparticles, targeting biomedical applications

Abstract: This study proposes a bio-directed approach for the formation of titanium oxide and silver nanoparticles (TiO2 and Ag NPs), using a wild mushroom, Fomitopsis pinicola, identified by 18S ribosomal RNA gene sequencing (gene accession no. MK635350) and phenotypic examination.

Cited by 50 publications

References 35 publications

Biofabricated Fatty Acids-Capped Silver Nanoparticles as Potential Antibacterial, Antifungal, Antibiofilm and Anticancer Agents

Biofabricated Fatty Acids-Capped Silver Nanoparticles as Potential Antibacterial, Antifungal, Antibiofilm and Anticancer Agents

The interrelationships between antimicrobial resistance, COVID-19, past, and future pandemics

Development of micro/nanostructured‒based biomaterials with biomedical applications

Contact Info

Product

Resources

About