Using Drosophila to Reveal Insight into Protein Misfolding Diseases

Proteotoxic stress and the ubiquitin proteasome system

“…Diseases that are driven by misfolded and aggregated proteins are known as protein misfolding diseases[ 2 ]. Some of these diseases, like cystic fibrosis, are loss of function diseases driven by specific protein mutations that cause misfolding and target the protein for degradation[ 29 , 30 ].…”