Using <i>Cordyceps militaris</i> extracellular polysaccharides to prevent Pb<sup>2+</sup>-induced liver and kidney toxicity by activating Nrf2 signals and modulating gut microbiota

Song, Qi; Zhu, Zhiwei

doi:10.1039/d0fo01608j

Cited by 37 publications

(30 citation statements)

References 52 publications

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“…Cordyceps militaris and its functional components have beneficial effects on human health that are associated with the host gut microbiota. Extensive research on the extracellular polysaccharide of Cordyceps militaris has been carried out regarding its regulatory effect on gut microbiota [ 167 ]. It was also reported that cordycepin reduced the body weight and regulated the constitution of gut microbiota in high-fat diet (HFD)-induced obese rats [ 168 ].…”

Section: The Role Of Autophagy In the Health-promoting Effects Of Cordycepinmentioning

confidence: 99%

The Role of Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin

Chen

Lin

et al. 2021

Molecules

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Cordycepin is an adenosine derivative isolated from Cordyceps sinensis, which has been used as an herbal complementary and alternative medicine with various biological activities. The general anti-cancer mechanisms of cordycepin are regulated by the adenosine A3 receptor, epidermal growth factor receptor (EGFR), mitogen-activated protein kinases (MAPKs), and glycogen synthase kinase (GSK)-3β, leading to cell cycle arrest or apoptosis. Notably, cordycepin also induces autophagy to trigger cell death, inhibits tumor metastasis, and modulates the immune system. Since the dysregulation of autophagy is associated with cancers and neuron, immune, and kidney diseases, cordycepin is considered an alternative treatment because of the involvement of cordycepin in autophagic signaling. However, the profound mechanism of autophagy induction by cordycepin has never been reviewed in detail. Therefore, in this article, we reviewed the anti-cancer and health-promoting effects of cordycepin in the neurons, kidneys, and the immune system through diverse mechanisms, including autophagy induction. We also suggest that formulation changes for cordycepin could enhance its bioactivity and bioavailability and lower its toxicity for future applications. A comprehensive understanding of the autophagy mechanism would provide novel mechanistic insight into the anti-cancer and health-promoting effects of cordycepin.

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Section: The Role Of Autophagy In the Health-promoting Effects Of Cordycepinmentioning

confidence: 99%

The Role of Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin

Chen

Lin

et al. 2021

Molecules

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“…An ethanol extract of C. militaris showed in vitro antioxidant activity against DPPH, superoxide, and hydroxyl radicals and low-density lipoproteins [130]. Extracellular polysaccharide from C. militaris effectively regulated key proteins such as HO-1, Nrf2, Kelch-like ECH-associated protein-1 (Keap1), and quinone oxidoreductase 1 (NQO1) in the Nrf2 signaling pathway [131]. He et al also supported the anti-inflammatory property of an ethanol extract of C. militaris via the suppression of H2O2-stimulated cell injury related to ROS overproduction and downregulated mitogen-activated protein kinases in C6 glial cells [132].…”

Section: Antioxidant Potentialmentioning

confidence: 99%

Cordyceps militaris as a Bio Functional Food Source: Pharmacological Potential, Anti-Inflammatory Actions and Related Molecular Mechanisms

2022

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Cordyceps militaris (C. militaris) is a medicinal mushroom possessing a variety of biofunctionalities. It has several biologically important components such as polysaccharides and others. The diverse pharmacological potential of C. militaris has generated interest in reviewing the current scientific literature, with a particular focus on prevention and associated molecular mechanisms in inflammatory diseases. Due to rising global demand, research on C. militaris has continued to increase in recent years. C. militaris has shown the potential for inhibiting inflammation-related events, both in in vivo and in vitro experiments. Inflammation is a multifaceted biological process that contributes to the development and severity of diseases, including cancer, colitis, and allergies. These functions make C. militaris a suitable functional food for inhibiting inflammatory responses such as the regulation of proinflammatory cytokines. Therefore, on the basis of existing information, the current study provides insights towards the understanding of anti-inflammatory activity-related mechanisms. This article presents a foundation for clinical use, and analyzes the roadmap for future studies concerning the medical use of C. militaris and its constituents in the next generation of anti-inflammatory drugs.

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“…The capillary vascularization of these hepatic sinusoidal endothelial cells in the endothelial basement membrane forms multiple pathological factors and occurs during the early stages of liver fibrosis, thereby altering liver function (4). Disorders of the intestinal flora can also lead to liver disease occurrence and development (5). Notably, the intestine and liver are inseparable from each other…”

Section: Introductionmentioning

confidence: 99%

Traditional Chinese medicine, liver fibrosis, intestinal flora: is there any connection?—a narrative review

Liu¹,

Qi²,

Sun³

2021

Ann Palliat Med

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This paper aims to analyze how intestinal flora regulates liver fibrosis pathogenesis and to evaluate the regulatory effect of traditional Chinese medicine on the intestinal flora, providing new insights into liver fibrosis treatment. Destruction of the intestinal microbiome can lead to liver fibrosis development, accelerating the intestinal microbiome's disruption. Traditional Chinese Medicine can effectively regulate the intestinal flora, helping prevent and treat liver fibrosis. This review discusses the mechanisms behind intestinal flora changes in liver fibrosis and how traditional Chinese medicine can regulate these changes.We searched PubMed, the Wanfang database, and CNKI for "liver fibrosis", "intestinal microflora", and "intestinal microbiota" and reviewed the retrieved literature. We detail the prevention and treatment options for liver fibrosis though the use of traditional Chinese medicine in regulating intestinal flora. We also highlight the influence of the intestinal flora on liver fibrosis and present the research regarding the prevention and treatment of liver fibrosis using traditional Chinese medicine. We also describe the effects of traditional Chinese medicine on the intestinal flora. Traditional Chinese medicine can effectively regulate the intestinal flora to prevent and treat liver fibrosis through the liver-intestine axis.

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Using Cordyceps militaris extracellular polysaccharides to prevent Pb²⁺-induced liver and kidney toxicity by activating Nrf2 signals and modulating gut microbiota

Abstract: In this study, we investigated the protective efficacy of an extracellular polysaccharide of Cordyceps militaris (CEP-I) to liver and kidney, and the regulating effect on gut microbiota to against Pb-induced...

Cited by 37 publications

References 52 publications

The Role of Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin

The Role of Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin

Cordyceps militaris as a Bio Functional Food Source: Pharmacological Potential, Anti-Inflammatory Actions and Related Molecular Mechanisms

Traditional Chinese medicine, liver fibrosis, intestinal flora: is there any connection?—a narrative review

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Using Cordyceps militaris extracellular polysaccharides to prevent Pb2+-induced liver and kidney toxicity by activating Nrf2 signals and modulating gut microbiota

Abstract: In this study, we investigated the protective efficacy of an extracellular polysaccharide of Cordyceps militaris (CEP-I) to liver and kidney, and the regulating effect on gut microbiota to against Pb-induced...

Cited by 37 publications

References 52 publications

The Role of Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin

The Role of Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin

Cordyceps militaris as a Bio Functional Food Source: Pharmacological Potential, Anti-Inflammatory Actions and Related Molecular Mechanisms

Traditional Chinese medicine, liver fibrosis, intestinal flora: is there any connection?—a narrative review

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Using Cordyceps militaris extracellular polysaccharides to prevent Pb²⁺-induced liver and kidney toxicity by activating Nrf2 signals and modulating gut microbiota