Using Hydrogen Bonds to Design Acentric Organic Materials for Nonlinear Optical Users

Growth and characterization of a solution grown, new organic crystal: l-histidine-4-nitrophenolate 4-nitrophenol (LHPP)

“…117.83(14) C(4)-C(5)-C (6) 119.75(13) C(1)-C(6)-C (5) 120.05(16) C(8)-C(7)-C (12) 121.21(15) C(7)-C(8)-C (9) 120.03(14) C(8)-C(9)-C (10) 120.46(13) C(8)-C(9)-N(2) 120.16(14) C(10)-C(9)-N (2) 119.38(15) C(11)-C(10)-C (9) 119.73(15) C(10)-C(11)-C (12) 121.37(14) O(5)-C(12)-C (11) 122.30(13) O(5)-C(12)-C (7) 120.57(13) C(11)-C(12)-C (7) 117.13 (12) 108.95(12) C(13)-N(4)-C (14) 107.56(12) Table 4 Hydrogen bonds for hnp1 (Å and deg. (2) Symmetry transformations used to generate equivalent atoms: #1 À x +3, y+ 1/2, À z + 2#2 À x +3, y À 1/2, À z + 2#3 À x +2, y +1/2, À z+ 1#4x+1, y, z.…”

“…The cocrystallization of two chromophores, effectively an acid and a base, is a common approach to the design of materials for NLO [13,14]. Alcohols and anilines are likely to crystallize in acentric space groups because of their tendencies to form hydrogen bonds.…”

Cocrystal Formation during Cogrinding and Storage is Mediated by Amorphous Phase

“…One way to cope with the complexities of solution-based methods has been to screen for cocrystals by cogrinding solid reactants (4,6,9,17,22). Although examples of cocrystals formed by this process are abundant, the underlying mechanisms and the factors that determine cocrystallization by cogrinding are not known.…”

Identification of a new cocrystal of citric acid and paracetamol of pharmaceutical relevance

“…5 C. It is interesting that the cocrystal product also shows two endotherms at 72.05 and 94. 10 C, separated by a broad exotherm. This can be interpreted as a transition between enantiotropic polymorphic forms of the cocrystal.…”

“…In the crystalline state, hydrogen bonds are accountable for the creation of families of molecular networks with the same molecular components or with different molecular components (multiple component crystals or cocrystals). [5][6][7][8][9][10][11][12][13][14][15] The cocrystals are stabilized through a variety of different intermolecular interactions including hydrogen bonds, aromatic p-stacking, and van der Waals forces, and unlike salt formation, no proton transfer occurs between the API and the guest molecule. 16 Slow evaporation and grinding are the most commonly used techniques for producing cocrystals.…”