Using higher‐order crossings to distinguish liver regeneration indices in hepatectomized diabetic and non‐diabetic rats

Liatsos, Christos; Hadjileontiadis, Leontios; Theocharis, S.; Petridou, Evangelia; Margeli, Alexandra; Skaltsas, S.; Mavrogiannis, Christos; Mykoniatis, Michael G.

doi:10.1111/j.1440-1746.2004.03493.x

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…One of the methods of analysis found in the studies based on fuzzy logic was c-means, which permits grouping data to estimate each cluster center, the distance among data to the center, and the distance between the centers of two clusters (12) .…”

Section: Fuzzy Logic As Methodsmentioning

confidence: 99%

Nursing and fuzzy logic: an integrative review

Jensen

Lopes

2011

Rev. Latino-Am. Enfermagem

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This study conducted an integrative review investigating how fuzzy logic has been used in research with the participation of nurses. The article search was carried out in the CINAHL, EMBASE, SCOPUS, PubMed and Medline databases, with no limitation on time of publication. Articles written in Portuguese, English and Spanish with themes related to nursing and fuzzy logic with the authorship or participation of nurses were included. The final sample included 21 articles from eight countries. For the purpose of analysis, the articles were distributed into categories: theory, method and model. In nursing, fuzzy logic has significantly contributed to the understanding of subjects related to: imprecision or the need of an expert; as a research method; and in the development of models or decision support systems and hard technologies. The use of fuzzy logic in nursing has shown great potential and represents a vast field for research.Descriptors: Nursing; Fuzzy Logic; Review Literature as Topic. 1 Paper extracted from Master's Thesis "Desenvolvimento e avaliação de um programa computacional baseado em lógica fuzzy para verificação da acurácia diagnóstica de estudantes de enfermagem" presented to Programa de Pós Graduação, Universidade Estadual Enfermagem e lógica fuzzy: uma revisão integrativaEste estudo teve como objetivo realizar revisão integrativa, investigando como a lógica fuzzy tem sido utilizada em pesquisas com participação de enfermeiros. A busca dos artigos foi realizada nas bases de dados CINAHL, Embase, Scopus, MEDLINE e PubMed, sem intervalo de anos especificado. Foram incluídos artigos na língua portuguesa, inglesa e espanhola; com temática relacionada à enfermagem e à lógica fuzzy, e autoria ou participação de enfermeiros. A amostra final foi de 21 artigos, de oito países. Para análise, os artigos foram distribuídos nas categorias: teoria, método e modelo. Na enfermagem, a lógica fuzzy tem contribuído significativamente para a compreensão de temas relativos à imprecisão ou à necessidade do especialista, como método de pesquisa e no desenvolvimento de modelos ou sistemas de apoio à decisão e de tecnologias duras.O uso da lógica fuzzy, na enfermagem, tem demonstrado grande potencial e representa vasto campo para pesquisas.Descritores: Enfermagem; Lógica Fuzzy; Literatura de Revisão como Assunto. Enfermería y lógica fuzzy: una revisión de integradoraEste estudio tuvo como objetivo realizar una revisión integradora investigando como la lógica fuzzy ha sido utilizada en investigaciones con participación de enfermeros. La búsqueda de los artículos fue realizada en las bases de datos CINAHL, Embase, SCOPUS, Medline y PubMed, sin especificar un intervalo de años determinado. Fueron incluidos artículos en los idiomas: portugués, inglés y castellano; con una temática relacionada a la enfermería y a la lógica fuzzy; y con autoría o participación de enfermeros. La muestra final fue de 21 artículos, de ocho países. Para el análisis, los artículos fueron distribuidos en las categorías: teoría, método y modelo. En la e...

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Section: Fuzzy Logic As Methodsmentioning

confidence: 99%

Nursing and fuzzy logic: an integrative review

Jensen

Lopes

2011

Rev. Latino-Am. Enfermagem

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Mechanisms and Outcomes of Drug- and Toxicant-Induced Liver Toxicity in Diabetes

Wang

Shankar

Ronis

et al. 2007

Critical Reviews in Toxicology

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Increase dincidences of hepatotoxicity have been observed in diabetic patients receiving drug therapies. Neither the mechanisms nor the predisposing factors underlying hepatotoxicity in diabetics are clearly understood. Animal studies designed to examine the mechanisms of diabetes-modulated hepatotoxicity have traditionally focused only on bioactivation/detoxification of drugs and toxicants. It is becoming clear that once injury is initiated, additional events determine the final outcome of liver injury. Foremost among them are two leading mechanisms: first, biochemical mechanisms that lead to progression or regression of injury; and second, whether or not timely and adequate liver tissue repair occurs to mitigate injury and restore liver function. The liver has a remarkable ability to repair and restore its structure and function after physical or chemical-induced damage. The dynamic interaction between biotransformation-based liver injury and compensatory tissue repair plays a pivotal role in determining the ultimate outcome of hepatotoxicity initiated by drugs or toxicants. In this review, mechanisms underlying altered hepatotoxicity in diabetes with emphasis on both altered bioactivation and liver tissue repair are discussed. Animal models of both marked sensitivity (diabetic rats) and equally marked protection (diabetic mice) from drug-induced hepatotoxicity are described. These examples represent a remarkable species difference. Availability of the rodent diabetic models offers a unique opportunity to uncover mechanisms of clinical interest in averting human diabetic sensitivity to drug-induced hepatotoxicities. While the rat diabetic models appear to be suitable, the diabetic mouse models might not be suitable in preclinical testing for potential hepatotoxic effects of drugs or toxicants, because regardless of type 1 or type2 diabetes, mice are resistant to acute drug-or toxicant-induced toxicities.

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Using higher‐order crossings to distinguish liver regeneration indices in hepatectomized diabetic and non‐diabetic rats

Cited by 2 publications

References 34 publications

Nursing and fuzzy logic: an integrative review

Nursing and fuzzy logic: an integrative review

Mechanisms and Outcomes of Drug- and Toxicant-Induced Liver Toxicity in Diabetes

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