Using High Spectral and Spatial Resolution Bold MRI to Choose the Optimal Oxygenating Treatment for Individual Cancer Patients

Al‐Hallaq, Hania; Zamora, Marta; Fish, Brian L.; Halpern, Howard J.; Moulder, John E.; Karczmar, Gregory S.

doi:10.1007/978-1-4615-0075-9_40

Cited by 10 publications

(9 citation statements)

References 12 publications

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“…HiSS datasets can be used to synthesize images in which intensity is proportional to peak height, peak frequency, or linewidth. Changes in the water signal linewidth, which are proportional to changes in R 2 * , has been reported to detect BOLD contrast change in tumors during carbogen breathing [55,56]. HiSS MRI can emphasize changes in necrotic and/or hemorrhagic regions, so that it is more sensitive to oxygenation changes compared to conventional MRI.…”

Section: Boldmentioning

confidence: 98%

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Current Issues in the Utility of Blood Oxygen Level Dependent MRI for the Assessment of Modulations in Tumor Oxygenation

Baudelet¹,

Gallez

2005

CMIR

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It has been known for some time now that hypoxia is an important physiological parameter in tumor growth and response to therapy. The development and application of non invasive methods to determine the extent of tumor hypoxia as well as its modulation will improve cancer treatment strategies. Magnetic Resonance sequences that are based on the BOLD effect use the endogenous contrast agent deoxyhemoglobin as a source of contrast. This technique can be used to monitor the evolution of tumor oxygenation since there is a good correlation between the evolution of the partial pressure of oxygen (pO 2 ) and the NMR parameters measured. The information provided by BOLD NMR is essentially qualitative in nature due to the complexity of the relationship between the pO 2 and the NMR parameters measured. The factors at the origin of this complex relationship are discussed in this review. The advantages of the BOLD technique are non invasiveness and high spatial and temporal resolution. The method has been successfully applied in experimental and human tumors to monitor changes after respiratory challenges and pharmacological treatments. Additionally, the method has been used to provide maps of mature and functional tumor vessels and maps of spontaneous fluctuations of oxygenation and blood perfusion related to tumor acute hypoxia.

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Section: Boldmentioning

confidence: 98%

“…BOLD contrast changes can also be detected with high spectral and spatial resolution (HiSS) MRI rather than with GRE imaging [54][55][56]. Most MRI methods assume that the water resonance behaves as a single Lorentzian distribution of frequencies.…”

Section: Boldmentioning

confidence: 99%

Current Issues in the Utility of Blood Oxygen Level Dependent MRI for the Assessment of Modulations in Tumor Oxygenation

Baudelet¹,

Gallez

2005

CMIR

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“…If so, it may be possible to identify potential responsive tumors with BOLD MRI techniques before start of treatment [9,36,37]. However, BOLD MRI was not uniform in animal and patient studies after carbogen breathing, with even reports of a decrease in oxygenation status [1,9,10,36,38]. Also, intratumor heterogeneity was observed, areas with increased oxygenation and areas with little or no response were found [1,10].…”

Section: Discussionmentioning

confidence: 99%

“…However, BOLD MRI was not uniform in animal and patient studies after carbogen breathing, with even reports of a decrease in oxygenation status [1,9,10,36,38]. Also, intratumor heterogeneity was observed, areas with increased oxygenation and areas with little or no response were found [1,10]. Therefore, although in general, results of treatment with radiation and carbogen in patients with GBM have been disappointing, a subpopulation of patients may be identified based on BOLD MRI techniques that could benefit from the addition of carbogen to radiation.…”

Section: Discussionmentioning

confidence: 99%

Effect of Carbogen Breathing on the Radiation Response of a Human Glioblastoma Xenograft

et al. 2006

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“…MGRE-MRI is considered particularly useful for assessing changes in oxygenation after manipulation therapies like carbogen breathing and its effect on radiation response [90]. Fluctuations in BOLD contrast can also be analysed by high spectral and spatial resolution MRI (HiSS-MRI) [91]. This is a recent advancement and still in its incipient stage.…”

Section: Magnetic Resonance (Mr) Techniquesmentioning

confidence: 99%

Advances in methods for assessing tumor hypoxia in vivo: Implications for treatment planning

Davda

Bezabeh

2006

Cancer Metastasis Rev

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Tumor hypoxia and its downstream effects have remained of considerable interest for decades due to its negative impact on response to various cancer therapies and promotion of metastasis. Diagnosing hypoxia non-invasively can provide a significant advancement in cancer treatment and is the dire necessity for implementing specific targeted therapies now emerging to treat different aspects of cancer. A variety of techniques are being proposed to do so. However, none of them has yet been established in the clinical arena. This review summarizes the methods currently available to assess tumor hypoxia in vivo and their respective advantages and shortcomings. It also points out the impedances that need to be overcome to establish any particular method in the clinic, along with a broad overview of requirements for further advancement in this sphere of cancer research.

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Using High Spectral and Spatial Resolution Bold MRI to Choose the Optimal Oxygenating Treatment for Individual Cancer Patients

Cited by 10 publications

References 12 publications

Current Issues in the Utility of Blood Oxygen Level Dependent MRI for the Assessment of Modulations in Tumor Oxygenation

Current Issues in the Utility of Blood Oxygen Level Dependent MRI for the Assessment of Modulations in Tumor Oxygenation

Effect of Carbogen Breathing on the Radiation Response of a Human Glioblastoma Xenograft

Advances in methods for assessing tumor hypoxia in vivo: Implications for treatment planning

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