Using Glissonian sheath as an alternative way to prevent biliary stricture in living-donor liver transplantation

Lin, Joseph; Ko, Chih‐Jan; Lin, Kuo‐Hua; Lin, Ping‐Yi; Hsieh, Chia-En; Chou, Chen‐Te; Chen, Yao‐Li; Hung, Yu-Ju

doi:10.1016/j.asjsur.2020.12.032

Cited by 5 publications

(2 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Intraoperatively, technical modifications of choledochocholedochostomy helped improved the stricture rate. A theoretically higher risk of biliary tract ischemia was suggested of an end-to-end anastomosis as it added fragility and an impaired perfusion at the distal end of the bile duct [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

The role of Roux-en-Y hepaticojejunostomy for the management of biliary complications after living donor liver transplantation

et al. 2023

Self Cite

View full text Add to dashboard Cite

Introduction Post living donor liver transplantation (LDLT) biliary complications can be troublesome over the post-operative course of patients, especially those with recurrent cholangitis or choledocholithiasis. Thus, in this study, we aimed to evaluate the risks and benefits of Roux-en-Y hepaticojejunostomy (RYHJ) performed after LDLT as a last option to deal with post-LDLT biliary complications. Methods Retrospectively, of the 594 adult LDLTs performed in a single medical center in Changhua, Taiwan from July 2005 to September 2021, 22 patients underwent post-LDLT RYHJ. Indications for RYHJ included choledocholithiasis formation with bile duct stricture, previous intervention failure, and other factors. Restenosis was defined if further intervention was needed to treat biliary complications after RYHJ was performed. Thereafter, patients were categorized into success group (n = 15) and restenosis group (n = 4). Results The overall success rate of RYHJ in the management of post-LDLT biliary complications was 78.9% (15/19). Mean follow-up time was 33.4 months. As per our findings, four patients experienced recurrence after RYHJ (21.2%), and mean recurrence time was 12.5 months. Three cases were recorded as hospital mortality (13.6%). Outcome and risk analysis presented no significant differences between the two groups. A higher risk of recurrence tended to be related to patients with ABO incompatible (ABOi). Conclusion RYHJ served well as either a rescue but definite procedure for recurrent biliary complications or a safe and effective solution to biliary complications after LDLT. A higher risk of recurrence tended to be related to patients with ABOi; however, further research would be needed.

show abstract

Section: Introductionmentioning

confidence: 99%

The role of Roux-en-Y hepaticojejunostomy for the management of biliary complications after living donor liver transplantation

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…Cholestasis leads to impaired liver function; only a few patients can be successfully treated by endoscopic stents and drainage tubes or surgical treatment. However, most patients still lack safe and effective treatment measures [ 2 – 4 ]. Therefore, preventing and treating biliary complications after liver transplantation is an urgent clinical problem to be solved.…”

Section: Introductionmentioning

confidence: 99%

IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo

Bai

Zhang

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Biliary complications are currently one of the leading causes of liver failure and patient death after liver transplantation and need to be solved urgently. Biliary ischemia-reperfusion injury (IRI) is one of the important causes of biliary complications. IL-22 has a protective effect on liver injury and hepatitis diseases, and its safety and efficacy in the treatment of hepatitis have also been proved in human clinical experiments. Furthermore, multiple studies have confirmed that IL-22 promotes the proliferation and repair of epithelial cells in various organs. Still, its function in the bile duct after transplantation has not been explored. This study was aimed at investigating the effects of IL-22 on cholangiocyte IRI in vitro and in vivo and exploring its underlying mechanisms. We simulated the hypoxia process of bile duct epithelial cells through in vitro experiments to investigate the protective function and molecular mechanism of IL-22 on bile duct epithelial cells. Subsequently, the function and mechanism of IL-22 in the biliary IRI model of autologous orthotopic liver transplantation in rats were assessed. This study confirmed that IL-22 could promote cholangiocyte proliferation, decrease the apoptosis rate of cholangiocytes and tissues, decrease MDA levels, and increase SOD levels by activating STAT3. In addition, IL-22 can also reduce the level of mitochondrial membrane depolarization, protect mitochondria, reduce ROS production, and play a role in protecting bile ducts. These findings provide evidence for IL-22 as a novel and effective treatment for biliary IRI after liver transplantation.

show abstract

Risk factors for biliary strictures and leaks after living-donor liver transplantation: a systematic review and meta-analysis

Hassouneh,

Beran,

Rosenheck

et al. 2024

Journal of Gastrointestinal Surgery

View full text Add to dashboard Cite

Using Glissonian sheath as an alternative way to prevent biliary stricture in living-donor liver transplantation

Cited by 5 publications

References 27 publications

The role of Roux-en-Y hepaticojejunostomy for the management of biliary complications after living donor liver transplantation

The role of Roux-en-Y hepaticojejunostomy for the management of biliary complications after living donor liver transplantation

IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo

Risk factors for biliary strictures and leaks after living-donor liver transplantation: a systematic review and meta-analysis

Contact Info

Product

Resources

About