Using ginger supplement in adjunct with non-surgical periodontal therapy improves metabolic and periodontal parameters in patients with type 2 diabetes mellitus and chronic periodontitis: A double-blind, placebo-controlled trial

Gholinezhad, Hasan; Bazyar, Hadi; Rashidi, Homeira; Salehi, Parvin; Haghighizadeh, Mohammad Hosein; Javid, Ahmad Zare

doi:10.1016/j.hermed.2019.100315

Cited by 13 publications

(22 citation statements)

References 37 publications

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“…The duration of ginger consumption varied from four to 12 weeks. Of the 12 studies, four included participants with type 2 diabetes (Azimi et al., 2014; Gholinezhad et al., 2020; Javid et al., 2019; Shidfar et al., 2015), two included participants with final stage renal disease and peritoneal dialysis (Imani et al., 2015; Seddik, 2015), one included participants with cancer (Danwilai et al., 2017), one included obese participants (Attari et al., 2015), one included participants with ulcerative colitis (Nikkhah‐Bodaghi et al., 2019), one included subjects with non‐alcoholic fatty liver disease (Rafie et al., 2020), one included knee osteoarthritis patients (Naderi et al., 2016), and one included adults with tuberculosis (Kulkarni & Deshpande, 2016).…”

Section: Resultsmentioning

confidence: 99%

“…Our meta‐analysis also showed that ginger supplementation significantly increases TAC levels (five studies) (SMD: 0.40; 95% CI: 0.06, 0.73; I 2 = 42.8%) (Figure 5). Four studies (Attia et al., 2013; Gholinezhad et al., 2020; Nikkhah‐Bodaghi et al., 2019; Rafie et al., 2020) have shown that ginger intake non‐significantly increases TAC. One study showed that ginger intake increases TAC significantly (Shidfar et al., 2015).…”

Section: Resultsmentioning

confidence: 99%

“…After removing duplicates, 322 studies were screened at the title and abstract level and 304 articles were excluded. The remaining 18 were assessed at the full-text level, after which 12 were included in this study (Attari et al, 2015;Azimi et al, 2014;Danwilai et al, 2017;Gholinezhad et al, 2020;Imani et al, 2015;Javid et al, 2019;Kulkarni & Deshpande, 2016;Naderi et al, 2016;Nikkhah-Bodaghi et al, 2019;Rafie et al, 2020;Seddik, 2015;Shidfar et al, 2015) ( Figure 1).…”

Section: Study Selectionmentioning

confidence: 99%

“…The number of subjects in these studies ranged from thirty (Seddik, 2015) to one hundred (Naderi et al, 2016). The studies were published between 2014 and 2020 and performed in Iran (9 studies) (Attari et al, 2015;Azimi et al, 2014;Gholinezhad et al, 2020;Imani et al, 2015;Javid et al, 2019;Naderi et al, 2016;Nikkhah-Bodaghi et al, 2019;Rafie et al, 2020;Shidfar et al, 2015), Thailand (Danwilai et al, 2017), Saudi Arabia (Seddik, 2015) and India (Kulkarni & Deshpande, 2016). The mean age of the subjects ranged from 31 to 58 years.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…The duration of 52.9 ± 8.0 ginger consumption varied from four to 12 weeks. Of the 12 studies, four included participants with type 2 diabetes (Azimi et al, 2014;Gholinezhad et al, 2020;Javid et al, 2019;Shidfar et al, 2015), two…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Effect of ginger ( Zingiber officinale ) supplementation on oxidative stress parameters: A systematic review and meta‐analysis

et al. 2021

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A wide variety of antioxidant properties are attributed to ginger (Zingiber officinale) and several randomized controlled trials (RCTs) have investigated the effect of ginger intake on major oxidative stress (OS) parameters. We conducted a systematic review and meta-analysis to evaluate the effects of using ginger to improve OS levels. Medline, Scopus, ISI Web of Science, EMBASE, and the Cochrane Central Register of Controlled Trials were systematically searched up until March 2020 to gather RCTs that evaluated the impact of ginger intake on the levels and activity of OS parameters in adult subjects. Means and standard deviations for relevant OS variables were extracted and evaluated to assess the quality of the trials based on the Cochrane riskof-bias tool for randomized trials. The gathered data were pooled and expressed as standardized mean difference (SMD) with 95% Confidence Intervals (95% CI). Twelve trials were included in this review. Ginger intake was shown to significantly increase glutathione peroxidase (GPx) activity (SMD: 1.64; 95% CI: 0.43, 2.85; I 2 = 86.8%) and total antioxidant capacity (TAC) (SMD: 0.40; 95% CI: 0.06, 0.73; I 2 = 42.8%) and significantly decrease malondialdehyde (MDA) levels (SMD: −0.69; 95% CI: −1.26, −0.12; I 2 = 85.8%) compared to control groups. Ginger supplementation also non-significantly associated with an increase in CAT activity (SMD: 1.09; 95% CI: −0.07, 2.25; I 2 = 87.6%). This systematic review and meta-analysis presents convincing evidence supporting the efficacy of ginger supplementation on improving OS levels. Practical implications: In health sciences, OS, due to its pivotal role in the pathophysiology of several chronic diseases, is a subject with a long history. Recent research strives for a safe, ideal, and effective antioxidant. Ginger is herbal medicine, which has been widely used in traditional and complementary medicine. Proving the antioxidant effect and potential benefit of ginger has positive clinical implications for the application of this practical herb.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Effect of ginger ( Zingiber officinale ) supplementation on oxidative stress parameters: A systematic review and meta‐analysis

et al. 2021

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Antioxidant for treatment of diabetic complications: A meta‐analysis and systematic review

Zhong

Wang

et al. 2022

J Biochem & Molecular Tox

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Antioxidants may provide a complementary treatment for patients with chronic diseases. Nevertheless, studies that have measured the effects of antioxidant on diabetes complications have provided conflicting results. This study aimed to elucidate the association between antioxidant and diabetic complications and to develop robust evidence for clinical decisions by systematic reviews and meta‐analysis. PubMed, Embase, The Cochrane Library, Web of Science, Scopus databases were searched to collect clinical studies related to the efficacy of antioxidants in the treatment of diabetes complications from inception to May 5, 2021. Statistical meta‐analyses were performed using the RevMan 5.4 software. Stata16 software was used to detect publication bias. The data of diabetic nephropathy (DN), diabetic nonalcoholic fatty liver disease (NAFLD), and diabetic periodontitis were collected to analyze the effect of antioxidant on diabetes and the above three complications. The meta‐analysis results showed that antioxidant treatment was associated with significantly changes in the fasting plasma glucose (FPG) (standardized mean difference [SMD]: − 0.21 [95% confidence interval [CI]: − 0.33, −0.10], p < 0.001), hemoglobin A1c (HbA1c) (MD: − 0.41 [95% CI: − 0.63, −0.18], p < 0.001), total antioxidant capacity (TAC) (SMD: 0.44 [95% CI: 0.24, 0.63], p < 0.001) and malondialdehyde (MDA) (SMD: − 0.82 [95% CI: − 1.24, −0.41], p < 0.001) than the control group. Antioxidant supplements have the potential to treat three complications of diabetes. In conclusion, the meta‐analysis results indicate that antioxidant treatment is effective clinically for diabetes mellitus and its complications.

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Effect of ginger (Zingiber officinale) intake on human serum lipid profile: Systematic review and meta‐analysis

Salih

Alwan²,

Khadim

et al. 2023

Phytotherapy Research

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Dyslipidemia is associated with an increased risk of cardiovascular events. Effect of ginger supplementation on lipid profile in humans remains controversial particularly in diabetic patients. A systematic search was performed covering PubMed, Medline, and Scopus, Web of Science (ISI), and Google scholar from January 2010 to January 2022. Inclusion criteria were randomized controlled clinical trials (RCT) study design, at least one of lipid profile components triglyceride (TG), total cholesterol (TC), lowdensity lipoprotein (LDL-C), and high-density lipoprotein (HDL-C) measured before and after ginger consumption. For quantitative data synthesis, a random-effects model was applied. Pooled data showed that ginger intake reduced TC (SMD À0.44; 95% CI: À0.86, À0.02; p = 0.025) and TG (SMD -0.61; 95% CI: À1.14, À0.08; p = 0.024) levels significantly, but it has no significant effect on improving HDL-C (SMD 0.40; 95% CI: À0.01, 0.80; p = 0.057) and LDL-C (SMD À0.34; 95% CI: À0.81, 0.13; p = 0.153). Ginger supplementation decreased TG in obese and diabetic subjects more efficiently. In terms of ginger dose, the result of meta-regression found to be significant only for TC, so that increasing daily doses of ginger reduces TC levels by (β: À0.67; 95% CI: À1.28, À0.07; p = 0.028). Therefore, ginger could be considered as an effective lipid lowering nutraceuticals.

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Using ginger supplement in adjunct with non-surgical periodontal therapy improves metabolic and periodontal parameters in patients with type 2 diabetes mellitus and chronic periodontitis: A double-blind, placebo-controlled trial

Cited by 13 publications

References 37 publications

Effect of ginger ( Zingiber officinale ) supplementation on oxidative stress parameters: A systematic review and meta‐analysis

Effect of ginger ( Zingiber officinale ) supplementation on oxidative stress parameters: A systematic review and meta‐analysis

Antioxidant for treatment of diabetic complications: A meta‐analysis and systematic review

Effect of ginger (Zingiber officinale) intake on human serum lipid profile: Systematic review and meta‐analysis

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