Abstract:In advanced non-small cell lung cancer (NSCLC), response to immunotherapy is difficult to predict from pre-treatment information. Given the toxicity of immunotherapy and its financial burden on the healthcare system, we set out to identify patients for whom treatment is effective using mutational signatures from DNA mutations in pre-treatment tissue. Analysis of single base substitutions, doublet base substitutions, indels, and copy number alteration signatures in the discovery set (m=101 patients) linked toba… Show more
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