Using exhaled CO₂to guide initial respiratory support at birth: a randomised controlled trial

Abstract

NCT01739114; Results.

Chest compression during sustained inflation versus 3:1 chest compression:ventilation ratio during neonatal cardiopulmonary resuscitation: a randomised feasibility trial

“…However, a recent randomised trial comparing SI with positive pressure ventilation alone by our group did not find any difference in either pneumothoraxes and intraventricular haemorrhages 26. Similar, in the current trial we observed similar rates of pneumothoraxes and intraventricular haemorrhages between groups (table 2).…”

Incidence and Risk Factors for Hypoglycemia During Fetal-to-Neonatal Transition in Premature Infants

“…A second limitation was the smaller sample size which affected the statistical analysis of smaller populations and groups, most notably SGA infants. While two separate RCTs were combined for this study, they both occurred within an overlapping 16-month time period within the same hospital and with identical treatment protocols aside from the respiratory treatment intervention; therefore, no significant difference in treatment is likely to have affected hypoglycemia (10,11). In addition, this study examined the transition phase immediately after birth.…”

“…This was a secondary analysis from infants enrolled in previously published randomized controlled trials in premature infants (10,11). The studies were carried out at The Royal Alexandra Hospital in Edmonton, Alberta, Canada, a tertiary perinatal center admitting more than 350 infants with a birth weight of <1,500 g annually.…”

“…LGA, large for gestational age; MgSO 4 , magnesium sulfate; RST, resuscitationstabilization-triage team; SBP, systolic blood pressure; SD, Standard deviation; SGA, Small for gestational age. controlled trials (10,11). Deliveries were attended by the research team in addition to the Resuscitation-Stabilization-Triage team (RST-team) (neonatal nurse, respiratory therapist, nurse practitioner, and neonatal fellow).…”

Respiratory Distress Syndrome Management in Delivery Room

“…Thus, concerns regarding the safety of this technique still need to be clarified. A potential method could be end-tidal CO 2 (ETCO 2 ) monitoring, which have shown to be feasible to guide length of SI during resuscitation [38]. Also, the effectiveness of SI maneuver can be largely influenced by several factors, such as the different skill of the clinical team, interface through which a SI is delivered [39], the infant's respiratory effort [35] and mask leak [32].…”