Health related quality of life (HRQOL) In 1946, the World Health Organization defined health as, "a state of complete physical, mental, and social well-being and not merely the absence of disease or infirmity."1 Over the past seven decades, however, health has been narrowly measured in the literature mostly through morbidity and mortality outcomes.2 The quality of an individual's life has only recently become an important and more frequent measure of health.The Centers for Disease Control and Prevention (CDC) reports that quality of life (QOL) is a broad multidimensional concept that includes both positive and negative aspects of life as perceived by each individual.2 Quality of life is defined in many different ways by various organizations and can include many different aspects of life.2 However, the CDC focuses more specifically on health-related quality of life (HRQOL), or the aspects of overall QOL that effect either physical or mental health. 2 It is known that individuals with chronic diseases and disabilities report lower QOL levels and more unhealthy days compared with individuals without chronic diseases and disabilities.3 Recently, data have been published to show that a higher level of self-perceived well-being is associated with lower health care utilization and costs in individuals with chronic conditions. 4 This may be particularly important toCorresponding author: Thomas L. Lenz, PharmD Associate Professor, Department of Pharmacy Practice Creighton University, 2400 California Plaza Omaha, Nebraska 68178, Phone: 402-280-3144 Fax: 402-280-3320, Email: tlenz@creighton.edu employers as it may affect the overall financial state of an organization. Data exists to show the pharmacists can have a positive impact on the QOL of people with chronic conditions. 5-7 However, the authors could not find any data demonstrating the impact a pharmacist can have on the QOL of individuals in an employee health setting.The purpose of this analysis is to report the effect that a pharmacist can have on the HRQOL at baseline versus oneyear for employees with chronic conditions who participate in a pharmacist-run employee health risk reduction program. Prior to conducting the analysis, the project was submitted to the local Institutional Review Board for approval and oversight. The project was considered to be a continuous quality improvement measure of the employee risk reduction programs, and therefore, oversight was deemed unnecessary.