Using Discrete EVent System Specification in Real-Time (DEVSRT) in Order to Model and Simulate Artificial Pancreas.

Abstract

One of the key areas that are being paid special attention to is known as red biotechnology (i.e. biotechnology used in the medical field). An example of this is 'The Artificial Pancreas' specifically for diabetes mellitus. The device would be composed of a continuous glucose sensor that senses the user's sugar level, an insulin infusion pump that secretes insulin into the user's body when required; and an algorithm that regulates the insulin based on the glucose levels obtained from the sensor. In the past recent years, there have been significant developments in technology that are very specific to the artificial pancreas. Although these devices show promise of future device developments, it currently faces a lot of error and criticism. In order to minimize cost and time to build and verify such a complex system, one must first model and simulate the system. This methodology in turn provides risk-free testing environments and can also be tested with different scenarios. This thesis will focus on modelling and simulating the artificial pancreas using Discrete EVent System Specification in Real-Time (DEVSRT).This is accomplished by simulating both a meal model and a control algorithm to control the insulin pump based of the data provided by the continuous glucose monitor. The meal model simulation will validate the control algorithm model. The results indicate that the meal model was successfully modelled and validated via comparison to literature. While the control algorithm implemented is not effective when large meals are ingested. iii To my mother, Colette D'Souza, who is my rock and source of encouragement. If I have accomplished anything today it is because of you.iv There are a number of people without whose help this thesis might have not been written and to whom I am greatly indebted.First and foremost, I thank my thesis supervisor, Dr. Gabriel Wainer, for his support; guidance; and, encouragement throughout these past couple of years. It has been both a privilege and pleasure to work under your supervision.