Using dimethyl-β-cyclodextrin to make eye drops containing dexamethasone

Гаврилин, М. В.; Kompantseva, E. V.; Ushakova, L. S.

doi:10.1007/bf02219209

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Cyclodextrins As Hosts For Natural and Synthetic Steroids2

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1997

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“…Oral, − sublingual, buccal, intravenous and intracerebral, or transdermal − administrations have been made possible by complexation. Eyedrops bearing the steroidal drug dexamethasone ( 31 , Figure ) have been prepared using a cyclodextrin as the solubilizing agent …”

Section: Cyclodextrins As Hosts For Natural and Synthetic Steroidsmentioning

confidence: 99%

“…Eyedrops bearing the steroidal drug dexamethasone (31, Figure 11) have been prepared using a cyclodextrin as the solubilizing agent. 143 The chemical stability of delicate steroidal drugs under physiological conditions may be improved by complexation with cyclodextrins. Steroid esters, such as betamethasone-17-valerate (32, Figure 11), are sensitive to intramolecular transesterification.…”

Section: Cyclodextrins As Hosts For Natural and Synthetic Steroidsmentioning

confidence: 99%

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