Using Detachment‐Promoting Agents for the Prevention of Chronic Peritoneal Dialysis‐Associated Infections

Abstract

Biofilms are known to be responsible for chronic peritoneal dialysis (PD)-related infections. Such infections are still frequent among patients in PD. The aim of this study was to develop a new approach in the prevention of chronic PD-related infection by regular injection of specific formulations containing detachment-promoting agents. A biofilm reactor system reproducing PD-like operating conditions was developed. A first set of experiments allowed the assessment of the anti-biofilm efficacy of various formulations. Then, experiments were performed for a longer duration and selected formulations were tested and compared with taurolidine. Biofilm removal was quantified by calculating the percentage of coverage reduction compared with an untreated control. A regular weekly treatment led to a 97% reduction of the surface coverage although a daily treatment with taurolidine still left 48% of the biomass on the surface. Such treatment is recommended to reduce the frequencies of chronic PD-related infections.

Biofilm formation in long‐term central venous catheters in children with cancer: a randomized controlled open‐labelled trial of taurolidine versus heparin

“…In accordance with other studies we confirmed the reduction of CRBSIs in the experimental arm with catheters locked with taurolidine compared with the standard arm where catheters were locked with heparin (9,(15)(16)(17)(18). In a study from 2008, Branger et al showed that taurolidine reduced biofilm and growth of microbes in a biofilm reactor system (24). Another study by Shah et al found that taurolidine reduced both the growth of free bacteria as well as the development of biofilm (13).…”

“…In a study from 2008, Branger et al. showed that taurolidine reduced biofilm and growth of microbes in a biofilm reactor system . Another study by Shah et al.…”

Taurolidine Lock Solutions for the Prevention of Catheter-Related Bloodstream Infections: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

“…The database search yielded 126 studies, of which 96 were irrelevant. Thirty studies were further evaluated, of which 25 were excluded ( Figure 1 ) [16] , [17] , [20] , [21] , [23] , [24] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] . The last article fitting the search criteria was supplied by an automatic alert from Pubmed [26] .…”

Artificial Organs 2008: A Year in Review

“…Bernard Branger et al. (101) of the CHU de Nimes, Lyon, France investigated an approach to prevent chronic PD‐related infections by regular injection of specific formulations containing detachment promoting agents. A biofilm reactor system reproducing PD‐like operating conditions was developed for evaluation.…”