DOI: 10.1101/600536
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Akshay Markanday, Joachim Bellet, Marie E. Bellet, Ziad M. Hafed, Peter Thier

Abstract: AbstractOne of the most powerful excitatory synapses in the entire brain is formed by cerebellar climbing fibers, originating from neurons in the inferior olive, that wrap around the proximal dendrites of cerebellar Purkinje cells. The activation of a single olivary neuron is capable of generating a large electrical event, called “complex spike”, at the level of the postsynaptic Purkinje cell, comprising of a fast initial spike of large amplitude followed by a slow polyphasic t…

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