Using cyclodextrin complexation to enhance secondary photoprotection of topically applied ibuprofen

Godwin, Donald A.; Wiley, Cody J.; Felton, Linda A.

doi:10.1016/j.ejpb.2005.06.002

Cited by 33 publications

(26 citation statements)

References 27 publications

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“…For low concentration of HT the best photoprotection is achieved using an excess of cycodextrin. According with this property, cyclodextrins have been used for avoiding photoinactivation of active components in topically applied pharmaceuticals 20 and for prolonging action of UV absorbers in sunscreen products. 21 In conclusion we have carried out the first complexation study between the antioxidant hydroxytyrosol and cyclodextrins, the complexes being studied by NMR techniques.…”

Section: Effects Of Ht Complexation On Its Radical Scavenging Activitmentioning

confidence: 99%

Complexation of hydroxytyrosol with β-cyclodextrins. An efficient photoprotection

et al. 2010

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Section: Effects Of Ht Complexation On Its Radical Scavenging Activitmentioning

confidence: 99%

Complexation of hydroxytyrosol with β-cyclodextrins. An efficient photoprotection

et al. 2010

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“…Different strategies have been used to increase the local bioavailability of topically administered Ibuprofen. In order to increase the therapeutic efficacy of topically administered drugs, it is necessary to employ percutaneous absorption enhancer and appropriate vehicles (Brown et al, 2001;Santi et al, 2003;Chen et al, 2006;Godwin et al, 2006;Rhee et al, 2008). Hence, in this study, attempts have been made to enhance the transdermal permeation of Ibuprofen using niosomal formulation incorporated in Carbopol Õ 914 gel form.…”

Section: Introductionmentioning

confidence: 99%

Nonionic surfactant-based vesicular system for transdermal drug delivery

2014

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Objective: The objective of this study was to formulate and evaluate the Ibuprofen niosomal formulation as a transdermal drug delivery system. Materials and methods: Niosomes were prepared by a modified ethanol injection method, using Span 60, Tween 60 and Tween 65 as well as cholesterol with various cholesterol:surfactant molar ratios. The prepared vesicles were characterized for entrapment efficiency (EE), particle size, zeta potential and in vitro release study. Skin permeation studies were conducted using modified Franz diffusion cell, and excised rat skin was treated with niosomal, liposomal and conventional Carbopol 914 gel of Ibuprofen. Results and discussion: The results showed that the type of surfactant and molar ratio of cholesterol:surfactant altered the EE, size and in vitro drug release of niosomes. Higher EE was obtained with the niosomes prepared with cholesterol and Span 60 at molar ratio of 0.5:1. It has been observed that both niosomal and liposomal formulations enhanced the drug permeation and the percentage of accumulated dose in the skin compared to control conventional gel formulation. However, niosomes prepared by Span 60 and Tween 65 exhibited higher permeation and retention of Ibuprofen, respectively. Conclusion: Our results suggested that niosomal formulations could be used as a promising carrier for the Ibuprofen transdermal delivery system.

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“…CDs and a number of derivatives have been widely used in oral and parenteral drug delivery systems to improve aqueous solubility and chemical stability of drugs (2,(16)(17)(18)(19). Topical applications of CDs have also been investigated (20)(21)(22). Cyclodextrins differ by the number of glucose units forming the ring structure as well as chemical substitutions on the exterior of the "bucket."…”

Section: Introductionmentioning

confidence: 99%

Experimental and Computational Studies of Physicochemical Properties Influence NSAID-Cyclodextrin Complexation

Felton

Popescu²,

Wiley

et al. 2014

AAPS PharmSciTech

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Abstract. The objective of this research was to investigate physicochemical properties of an active pharmaceutical ingredient (API) that influence cyclodextrin complexation through experimental and computational studies. Native β-cyclodextrin (B-CD) and two hydroxypropyl derivatives were first evaluated by conventional phase solubility experiments for their ability to complex four poorly watersoluble nonsteroidal anti-inflammatory drugs (NSAIDs). Differential scanning calorimetry was used to confirm complexation. Secondly, molecular modeling was used to estimate Log P and aqueous solubility (S o ) of the NSAIDs. Molecular dynamics simulations (MDS) were used to investigate the thermodynamics and geometry of drug-CD cavity docking. NSAID solubility increased linearly with increasing CD concentration for the two CD derivatives (displaying an A L profile), whereas increases in drug solubility were low and plateaued in the B-CD solutions (type B profile). The calculated Log P and S o of the NSAIDs were in good concordance with experimental values reported in the literature. Side chain substitutions on the B-CD moiety did not significantly influence complexation. Explicitly, complexation and the associated solubility increase were mainly dependent on the chemical structure of the NSAID. MDS indicated that each NSAID-CD complex had a distinct geometry. Moreover, complexing energy had a large, stabilizing, and fairly constant hydrophobic component for a given CD across the NSAIDs, while electrostatic and solvation interaction complex energies were quite variable but smaller in magnitude.

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Using cyclodextrin complexation to enhance secondary photoprotection of topically applied ibuprofen

Cited by 33 publications

References 27 publications

Complexation of hydroxytyrosol with β-cyclodextrins. An efficient photoprotection

Complexation of hydroxytyrosol with β-cyclodextrins. An efficient photoprotection

Nonionic surfactant-based vesicular system for transdermal drug delivery

Experimental and Computational Studies of Physicochemical Properties Influence NSAID-Cyclodextrin Complexation

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