Using Circulating miRNAs as Biomarkers for the Evaluation and Monitoring of the Mitochondrial Damage in the Critically Ill Polytrauma Patients

Bedreag, Ovidiu Horea; Păpurică, Marius; Rogobete, Alexandru Florin; Săndesc, Dorel; Dumache, Raluca; Cradigati, Carmen Alina; Sărăndan, Mirela; Bratu, Lavinia Melania; Popovici, Sonia Elena; Sima, Laurentiu

doi:10.7754/clin.lab.2016.160121

Cited by 5 publications

(7 citation statements)

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“…From a molecular point of view, microRNAs are synthesized in the cell nucleus through the action of RNA polymerase II on certain specific genes. Hence, the initial species, the pri-microRNAs, are formed following complex reactions [13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35]. In the next step, RNAse III endonuclease, also called Drosha, activates the pri-microRNAs.…”

Section: Biochemical and Biosynthesis Aspects Of Micrornasmentioning

confidence: 99%

“…A series of complex mechanisms involved in the pathophysiology and biochemistry of sepsis have been studied for the past several years. However, the critically ill polytrauma patient is so complex biochemically and molecularly that no specific biochemical pathways have been found in which intervention could increase survival rates, or decrease the incidence of sepsis and multiple organ dysfunction syndrome (MODS) [3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25]. However, in the last few years, a series of microRNA epigenetic species have been identified.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, numerous studies have shown the importance of microRNAs in early diagnosis and possible future epigenetic therapies [6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33]. By examining microRNAs with respect to critically ill polytrauma patients, we can see important links between the development and modulation of the systemic inflammatory response, the immune system, coagulation status, and response to infections [7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22]. The paper aims to systematize the microRNA expressions that are closely related to the pathophysiological events involved in a critically ill polytrauma patient with sepsis.…”

Section: Introductionmentioning

confidence: 99%

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MicroRNA Expression is Associated with Sepsis Disorders in Critically Ill Polytrauma Patients

Rogobete

Săndesc

Bedreag

et al. 2018

Cells

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A critically ill polytrauma patient is one of the most complex cases to be admitted to the intensive care unit, due to both the primary traumatic complications and the secondary post-traumatic interactions. From a molecular, genetic, and epigenetic point of view, numerous biochemical interactions are responsible for the deterioration of the clinical status of a patient, and increased mortality rates. From a molecular viewpoint, microRNAs are one of the most complex macromolecular systems due to the numerous modular reactions and interactions that they are involved in. Regarding the expression and activity of microRNAs in sepsis, their usefulness has reached new levels of significance. MicroRNAs can be used both as an early biomarker for sepsis, and as a therapeutic target because of their ability to block the complex reactions involved in the initiation, maintenance, and augmentation of the clinical status.

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Section: Biochemical and Biosynthesis Aspects Of Micrornasmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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MicroRNA Expression is Associated with Sepsis Disorders in Critically Ill Polytrauma Patients

Rogobete

Săndesc

Bedreag

et al. 2018

Cells

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“…miRNA biosynthesis takes place in the cell nucleus. 11 The mechanisms that lead to the formation of miRNAs begin with the attack of RNA polymerase II on specific genes (Figure 1). Following the transcription reactions, the first pri-miRNAs are formed.…”

Section: Biogenesis and Biochemical Characteristics Of Mirnasmentioning

confidence: 99%

Detection of Myocardial Injury Using miRNAs Expression as Genetic Biomarkers in Acute Cardiac Care

Rogobete

Bedreag

Popovici

et al. 2016

Journal of Cardiovascular Emergencies

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Cardiovascular disease is a leading cause of death globally. At present, there are many ways to diagnose this pathophysiology. The greatest disadvantages related to current biomarkers are their low specificity, low selectivity and low accuracy. A new method, extensively studied recently, is the expression of miRNAs, used as genetic biomarkers for the early diagnosis of cardiovascular diseases. This paper presents an update of miRNAs species expression that can serve as early diagnostic biomarkers and for the continuous monitoring of patients with cardiovascular disease.

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“…In sepsis, the vascular endothelium is considerably affected, appearing changes in the mitochondrial functionality because of the repeated hypoxia episodes. This mitochondrial damage may induce a series of cellular and pathophysiological dysfunctions, increasing the chances of multiple organ dysfunction syndrome (MODS) and death 7 .…”

Section: Introductionmentioning

confidence: 99%

Association of CD14 rs2569190 polymorphism with mortality in shock septic patients who underwent major cardiac or abdominal surgery: A retrospective study

Jiménez‐Sousa

Liu

Medrano

et al. 2018

Sci Rep

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The aim of this study was to investigate the relationship between the CD14 rs2569190 polymorphism and death related to septic shock in white European patients who underwent major cardiac or abdominal surgery. We carried out a retrospective study in 205 septic shock patients. The septic shock diagnosis was established by international consensus definitions. The outcome variable was the death within 28, 60 and 90 days after septic shock diagnosis. The CD14 rs2569190 polymorphism was analyzed by Agena Bioscience’s MassARRAY platform. For the genetic association analysis with survival was selected a recessive inheritance model (GG vs. AA/AG). One hundred thirteen out of 205 patients (55.1%) died with a survival median of 39 days (95%CI = 30.6; 47.4). Patients with rs2569190 GG genotype had shorter survival probability than rs2569190 AA/AG genotype at 60 days (62.3% vs 50%; p = 0.035), and 90 days (62.3% vs 52.6%; p = 0.046). The rs2569190 GG genotype was associated with increased risk of septic shock-related death in the first 60 days (adjusted hazard ratio (aHR) = 1.67; p = 0.016) and 90 days (aHR = 1.64; p = 0.020) compared to rs2569190 AA/AG genotype. In conclusion, the presence of CD14 rs2569190 GG genotype was associated with death in shock septic patients who underwent major surgery. Further studies with bigger sample size are required to verify this relationship.

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Using Circulating miRNAs as Biomarkers for the Evaluation and Monitoring of the Mitochondrial Damage in the Critically Ill Polytrauma Patients

Cited by 5 publications

References 0 publications

MicroRNA Expression is Associated with Sepsis Disorders in Critically Ill Polytrauma Patients

MicroRNA Expression is Associated with Sepsis Disorders in Critically Ill Polytrauma Patients

Detection of Myocardial Injury Using miRNAs Expression as Genetic Biomarkers in Acute Cardiac Care

Association of CD14 rs2569190 polymorphism with mortality in shock septic patients who underwent major cardiac or abdominal surgery: A retrospective study

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