Using CHADS2 and CHA2DS2-VASc scores for mortality prediction in patients with chronic kidney disease

Hsu, Po-Chao; Lee, Wen-Hsien; Chen, Szu-Chia; Tsai, Yi‐Chun; Chen, Ying-Chih; Chu, Chun-Yuan; Lin, Tsung‐Hsien; Voon, Wen‐Chol; Lai, Wen‐Ter; Sheu, Sheng‐Hsiung; Su, Ho‐Ming

doi:10.1038/s41598-020-76098-y

Cited by 13 publications

(17 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, some misidentifications could exist. Comorbidity scores have been used for the prediction of stroke as well as other chronic diseases in recent studies [ 43 , 44 ]. For example, the CHA2DS2-VASc score includes risk factors such as age, sex, prior stroke history, diabetes, and hypertension [ 45 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

The impact of diabetes and osteoarthritis on the occurrence of stroke, acute myocardial infarction, and heart failure among older adults with non-valvular atrial fibrillation in Hawaii: a retrospective observational cohort study

et al. 2021

View full text Add to dashboard Cite

Background To date, little is known about cardiovascular disease risks among older adults with non-valvular atrial fibrillation by their association with diabetes and osteoarthritis status, based on longitudinal data with substantial amounts of non-white individuals. The objective of this study was to examine the risks for three cardiovascular diseases: stroke, acute myocardial infarction (AMI), and heart failure (HF), by diabetes and osteoarthritis status among older adults with non-valvular atrial fibrillation in Hawaii. Methods We conducted a retrospective observational cohort study for older adults (65 years and older) with non-valvular atrial fibrillation using the Hawaii Medicare data 2009–2017. Their risks for the three cardiovascular diseases by diabetes and osteoarthritis status (diabetes, osteoarthritis, diabetes and osteoarthritis, and without diabetes and osteoarthritis) were examined by multivariable Cox proportional hazard regression models. Results The analysis included 19,588 beneficiaries followed up for a maximum of 3288 days (diabetes: n = 4659, osteoarthritis: n = 1978, diabetes and osteoarthritis: n = 1230, without diabetes and osteoarthritis: n = 11,721). Among them, those diagnosed with the cardiovascular diseases were identified (stroke: diabetes n = 837, osteoarthritis n = 315, diabetes and osteoarthritis n = 184, without diabetes and osteoarthritis n = 1630)(AMI: diabetes n = 438, osteoarthritis n = 128, diabetes and osteoarthritis n = 118, without diabetes and osteoarthritis n = 603)(HF: diabetes n = 2254, osteoarthritis n = 764, diabetes and osteoarthritis n = 581, without diabetes and osteoarthritis n = 4272). After adjusting for age, sex, race/ethnicity, and other potential confounders, those with diabetes and osteoarthritis had higher risks for HF (hazard ratio: 1.21 95% confidence interval: 1.10–1.33) than those without diabetes and osteoarthritis. They also had higher risks than those with osteoarthritis for HF. Those with diabetes had higher risks for all three cardiovascular diseases than the other three groups. Conclusions Variation in cardiovascular disease risks for older adults with non-valvular atrial fibrillation in Hawaii exists with diabetes and osteoarthritis status.

show abstract

Section: Discussionmentioning

confidence: 99%

The impact of diabetes and osteoarthritis on the occurrence of stroke, acute myocardial infarction, and heart failure among older adults with non-valvular atrial fibrillation in Hawaii: a retrospective observational cohort study

et al. 2021

View full text Add to dashboard Cite

show abstract

“…CHA2DS2-VASc score was also used as a continuous variable to assess the risk, and was shown that CHA2DS2-VASc score is associated with a 38% increased risk for the composite endpoint [ 34 ]. Hsu et al evaluated the usefulness of CHADS2 and CHA2DS2-VASc scores for the prediction of CV and all-cause mortality in CKD [ 35 ]. Age, male gender, hypertension, heart failure and CHA2DS2-VASc score (HR 1.600; 95% CI 1.254–2.040; P < 0.001) were proven to be significant predictors of CV mortality.…”

Section: Cha2ds2vasc Score In Non-atrial Fibrillation Patients With Chronic Kidney Diseasementioning

confidence: 99%

“…Similarly, age, male gender, heart failure, CHA2DS2-VASc score (HR 1.503; 95% CI 1.300–1.739; P < 0.001) and angiotensin II receptor blockers use were significant predictors of all-cause mortality. Higher stage of CKD was also associated with increased all-cause mortality in CKD [ 35 ]. Recently, Vodošek Hojs et al performed a prospective study in non-dialysis CKD patients and assessed the role of CHA2DS2-VASc score in predicting CV and all-cause mortality in CKD.…”

Section: Cha2ds2vasc Score In Non-atrial Fibrillation Patients With Chronic Kidney Diseasementioning

confidence: 99%

Does CHA2DS2-VASc score predict mortality in chronic kidney disease?

et al. 2021

View full text Add to dashboard Cite

Chronic kidney disease (CKD) is a leading cause of morbidity and mortality worldwide. Assessment of cardiovascular (CV) and all-cause mortality in CKD patients is of particular importance. CHA2DS2-VASc (congestive heart failure, hypertension, age ≥ 75 years, diabetes, prior stroke, vascular disease, age 65–74 years, and sex) score was originally formulated to predict the annual thromboembolic risk in patients with nonvalvular atrial fibrillation (AF). The calculation of R2CHADS2 and R2CHA2DS2VASc scores awarded an additional 2 points for CrCl < 60 mL/min and GFR < 60 mL/min/1.73 m 2 . Recent studies have investigated whether CHA2DS2-VASc and R2CHADS ± VASC scores could be used to predict CV or all-cause mortality in patients with CKD. CHA2DS2-VASc score was proven to be a significant predictor of CV and all-cause mortality in CKD patients, and a higher CHA2DS2-VASc score was associated with increased mortality. These findings are quite promising, and they may help physicians to identify high-risk groups in this population.

show abstract

“…The only similar study done in CKD patients was performed by Hsu et al [19]. They included 437 nondialysis CKD patients that were arranged for echocardiographic examinations because of suspecting coronary artery disease, hypertension, heart failure, abnormal cardiac physical examination, and survey for dyspnea.…”

Section: Disscussionmentioning

confidence: 99%

“…Our patients were stable at the time of inclusion, without having acute cardiovascular problems. Since the study by Hsu et al [19] was done in Taiwan, probably most of the patients were of Asian descent, while all our patients were Caucasian. Additionally, they did not perform laboratory examinations in the study and consequently could not add them to their analysis.…”

Section: Disscussionmentioning

confidence: 99%

CHA2DS2-VASc Score as a Predictor of Cardiovascular and All-Cause Mortality in Chronic Kidney Disease Patients

et al. 2021

View full text Add to dashboard Cite

Introduction: Chronic kidney disease (CKD) is a risk factor for cardiovascular and all-cause mortality. Recognition of high-risk patients is important and could lead to a different approach and better treatment. The CHA2DS2-VASc score was originally used to predict cerebral infarction in patients with atrial fibrillation (AF), but it is also a useful predictor of outcome in other cardiovascular conditions, independent of AF. Therefore, the aim of our research was to assess the role of CHA2DS2-VASc score in predicting cardiovascular and all-cause mortality in CKD patients. Methods: Stable nondialysis CKD patients were included. At the time of inclusion, medical history data and standard blood results were collected and CHA2DS2-VASc score was calculated. Patients were followed till the same end date, until kidney transplantation or until their death. Results: Eighty-seven CKD patients were included (60.3 ± 12.8 years, 66% male). Mean follow-up time was 1,696.5 ± 564.6 days. During the follow-up, 21 patients died and 11 because of cardiovascular reasons. Univariate Cox regression analysis showed that CHA2DS2-VASc score is a significant predictor of cardiovascular and all-cause mortality. In multivariate Cox regression analysis, in which CHA2DS2-VASc score, serum creatinine, urinary albumin/creatinine, hemoglobin, high-sensitivity C-reactive protein, and intact parathyroid hormone were included, CHA2DS2-VASc score was an independent predictor of cardiovascular (HR: 2.04, CI: 1.20–3.45, p = 0.008) and all-cause mortality (HR: 2.06, CI: 1.43–2.97, p = 0.001). The same was true after adding total cholesterol, triglycerides, and smoking status to both the analyses. Conclusion: The CHA2DS2-VASc score is a simple, practical, and quick way to identify the risk for cardiovascular and all-cause mortality in CKD patients.

show abstract

Using CHADS2 and CHA2DS2-VASc scores for mortality prediction in patients with chronic kidney disease

Cited by 13 publications

References 21 publications

The impact of diabetes and osteoarthritis on the occurrence of stroke, acute myocardial infarction, and heart failure among older adults with non-valvular atrial fibrillation in Hawaii: a retrospective observational cohort study

The impact of diabetes and osteoarthritis on the occurrence of stroke, acute myocardial infarction, and heart failure among older adults with non-valvular atrial fibrillation in Hawaii: a retrospective observational cohort study

Does CHA2DS2-VASc score predict mortality in chronic kidney disease?

CHA<sub>2</sub>DS<sub>2</sub>-VASc Score as a Predictor of Cardiovascular and All-Cause Mortality in Chronic Kidney Disease Patients

Contact Info

Product

Resources

About