Using Bioinformatics Approach to Explore the Pharmacological Mechanisms of Multiple Ingredients in Shuang-Huang-Lian

Abstract

Due to the proved clinical efficacy, Shuang-Huang-Lian (SHL) has developed a variety of dosage forms. However, the in-depth research on targets and pharmacological mechanisms of SHL preparations was scarce. In the presented study, the bioinformatics approaches were adopted to integrate relevant data and biological information. As a result, a PPI network was built and the common topological parameters were characterized. The results suggested that the PPI network of SHL exhibited a scale-free property and modular architecture. The drug target network of SHL was structured with 21 functional modules. According to certain modules and pharmacological effects distribution, an antitumor effect and potential drug targets were predicted. A biological network which contained 26 subnetworks was constructed to elucidate the antipneumonia mechanism of SHL. We also extracted the subnetwork to explicitly display the pathway where one effective component acts on the pneumonia related targets. In conclusions, a bioinformatics approach was established for exploring the drug targets, pharmacological activity distribution, effective components of SHL, and its mechanism of antipneumonia. Above all, we identified the effective components and disclosed the mechanism of SHL from the view of system.

Investigating The Relationship Between Insomnia, Menopausal Syndrome and Depression and Exploring The Therapeutic Effects of Jieyu Pill

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Bioactive compounds of Shuang-Huang-Lian prescription and an insight into its binding mechanism by β2-adrenoceptor chromatography coupled with site-directed molecular docking

“…Shuang–Huang–Lian (SHL) prescription comprises Flos lonicerae , Radix scutellariae , and Fructus forsythiae . It is widely prescribed for the treatment of fever, cough, and sore throat in practice . Functional investigations have stated that SHL displays high efficacy in anti‐inflammation, antiviral, and antibacterial properties.…”

“…This issue necessitates the establishment of new assays that are capable of rapidly recognizing and screening bioactive compounds from traditional medicine.Shuang-Huang-Lian (SHL) prescription comprises Flos lonicerae, Radix scutellariae, and Fructus forsythiae. It is widely prescribed for the treatment of fever, cough, and sore throat in practice [5,6]. Functional investigations have stated that SHL displays high efficacy in anti-inflammation, antiviral, and antibacterial properties.…”