Using attenuation coefficients from optical coherence tomography as markers of vocal fold maturation

García, Juan Ruiz; Benboujja, Fouzi; Beaudette, Kathy; Guo, Rong; Boudoux, Caroline; Hartnick, Christopher J.

doi:10.1002/lary.25765

Cited by 18 publications

(25 citation statements)

References 33 publications

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“…3B, before computing the relative attenuation coefficients u t for each region of interest of the VF, the speckle noise was reduced by averaging five consecutive frames, and the signal was normalized for all patients to account for environmental variation between acquisitions (power source, tissue viscosity). Implemented in MATLAB, and as previously described 73,74 , the relative attenuation coefficients were estimated through a linear regression analysis on averaged logarithm scaled intensity profiles (A-lines) according to the single-scattering model 75 . To reduce bias in the selection of the region of analysis across volumes, we extracted features along the 45° midline from the VF edge epithelium.…”

Section: Methodsmentioning

confidence: 99%

“…Its clinical potential has been well-demonstrated in laryngeal studies, such as in subglottic stenosis in adults [24][25][26] , and neonates 27 , vibrating VFs [28][29][30] , VF injections 31 and with benign and malignant lesions 24,28,30,[32][33][34][35][36] . Furthermore, OCT provides means to characterize and quantify the mucosa motion with doppler analysis [28][29][30] , describe subglottic injuries with a second-order statistics 37 , and its composition with attenuation coefficients 38,39 . Its main limitation pertains to the clinical interpretation of OCT VF images (optical scattering).…”

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confidence: 99%

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Quantitative evaluation of the human vocal fold extracellular matrix using multiphoton microscopy and optical coherence tomography

Benboujja

Hartnick

2021

Sci Rep

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Identifying distinct normal extracellular matrix (ECM) features from pathology is of the upmost clinical importance for laryngeal diagnostics and therapy. Despite remarkable histological contributions, our understanding of the vocal fold (VF) physiology remains murky. The emerging field of non-invasive 3D optical imaging may be well-suited to unravel the complexity of the VF microanatomy. This study focused on characterizing the entire VF ECM in length and depth with optical imaging. A quantitative morphometric evaluation of the human vocal fold lamina propria using two-photon excitation fluorescence (TPEF), second harmonic generation (SHG), and optical coherence tomography (OCT) was investigated. Fibrillar morphological features, such as fiber diameter, orientation, anisotropy, waviness and second-order statistics features were evaluated and compared according to their spatial distribution. The evidence acquired in this study suggests that the VF ECM is not a strict discrete three-layer structure as traditionally described but instead a continuous assembly of different fibrillar arrangement anchored by predominant collagen transitions zones. We demonstrated that the ECM composition is distinct and markedly thinned in the anterior one-third of itself, which may play a role in the development of some laryngeal diseases. We further examined and extracted the relationship between OCT and multiphoton imaging, promoting correspondences that could lead to accurate 3D mapping of the VF architecture in real-time during phonosurgeries. As miniaturization of optical probes is consistently improving, a clinical translation of OCT imaging and multiphoton imaging, with valuable qualitative and quantitative features, may have significant implications for treating voice disorders.

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Quantitative evaluation of the human vocal fold extracellular matrix using multiphoton microscopy and optical coherence tomography

Benboujja

Hartnick

2021

Sci Rep

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“…Microscope-integrated intraoperative OCT is already commercially available for imaging of ophthalmic surgical maneuvers [15,16,20]. Garcia et al [21] introduced an intraoperative OCT probe used for vocal fold imaging, which could also be applied to ear imaging if modified. The working distance of the objective lens is also an important consideration for clinical application.…”

Section: Discussionmentioning

confidence: 99%

Extratympanic Observation of Middle and Inner Ear Structures in Rodents Using Optical Coherence Tomography

Lee

Wang

et al. 2020

Clin Exp Otorhinolaryngol

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Objectives. This study aimed to investigate whether optical coherence tomography (OCT) provides useful information about the microstructures of the middle and inner ear via extratympanic approach and thereby could be utilized as an alternative diagnostic technology in ear imaging.Methods. Five rats and mice were included, and the swept-source OCT system was applied to confirm the extent of visibility of the middle and inner ear and measure the length or thickness of the microstructures in the ear. The cochlea was subsequently dissected following OCT and histologically evaluated to compare with the OCT images.Results. The middle ear microstructures such as ossicles, stapedial artery and oval window through the tympanic membrane with the OCT could be confirmed in both rats and mice. It was also possible to obtain the inner ear images such as each compartment of the cochlea in the mice, but the bone covering bulla needed to be removed to visualize the inner ear structures in the rats which had thicker bulla. The bony thickness covering the cochlea could be measured, which showed no significant differences between OCT and histologic image at all turns of cochlea. Conclusion.OCT has been shown a promising technology to assess real-time middle and inner ear microstructures noninvasively with a high-resolution in the animal model. Therefore, OCT could be utilized to provide additional diagnostic information about the diseases of the middle and inner ear.

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“…In recent study by Garcia et. al, a method based on analysis of attenuation coefficients in OCT data obtained in pediatric population was introduced to provide quantitative measure of vocal folds changes as a function of age [191]. Global anatomy of the airway: In addition to morphological information about wall architecture, OCT can also provide information about the shape and size of the airway that can be used for better understanding the pathophysiology behind conditions like obstructive sleep apnea (OSA).…”

Section: Otolaryngologymentioning

confidence: 99%

Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

Gora¹,

Suter²,

Tearney³

et al. 2017

Biomed. Opt. Express

253

203

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Abstract:In this paper, we review the current state of technology development and clinical applications of endoscopic optical coherence tomography (OCT). Key design and engineering considerations are discussed for most OCT endoscopes, including side-viewing and forwardviewing probes, along with different scanning mechanisms (proximal-scanning versus distalscanning). Multi-modal endoscopes that integrate OCT with other imaging modalities are also discussed. The review of clinical applications of endoscopic OCT focuses heavily on diagnosis of diseases and guidance of interventions. Representative applications in several organ systems are presented, such as in the cardiovascular, digestive, respiratory, and reproductive systems. A brief outlook of the field of endoscopic OCT is also discussed. References and links 1. T. Cao and H. L. Tey, "High-definition optical coherence tomography -an aid to clinical practice and research in dermatology," J. Dtsch. Dermatol. Ges. 13(9), 886-890 (2015). 2. J. Olsen, L. Themstrup, and G. B. Jemec, "Optical coherence tomography in dermatology," G. Ital. Dermatol.Venereol. 150(5), 603-615 (2015). 3. M. Ulrich, L. Themstrup, N. de Carvalho, M. Manfredi, C. Grana, S. Ciardo, R. Kästle, J. Holmes, R.Whitehead, G. B. Jemec, G. Pellacani, and J. Welzel, "Dynamic Optical Coherence Tomography in Dermatology," Dermatology (Basel) 232(3), 298-311 (2016). 4. G. J. Tearney, S. A. Boppart, B. E. Bouma, M. E. Brezinski, N. J. Weissman, J. F. Southern, and J. G. Fujimoto, "Scanning single-mode fiber optic catheter-endoscope for optical coherence tomography," Opt. Lett. 21(7), 543-545 (1996). 5. A. M. Rollins, R. Ung-Arunyawee, A. Chak, R. C. K. Wong, K. Kobayashi, M. V. Sivak, Jr., and J. A. Izatt, "Real-time in vivo imaging of human gastrointestinal ultrastructure by use of endoscopic optical coherence tomography with a novel efficient interferometer design," Opt. Lett. 24(19), 1358-1360 (1999). 6. M. V. Sivak, Jr., K. Kobayashi, J. A. Izatt, A. M. Rollins, R. Ung-Runyawee, A. Chak, R. C. Wong, G. A.Isenberg, and J. Willis, "High-resolution endoscopic imaging of the GI tract using optical coherence tomography," Gastrointest. Endosc. 51(4), 474-479 (2000). 7. J. Xi, A. Zhang, Z. Liu, W. Liang, L. Y. Lin, S. Yu, and X. Li, "Diffractive catheter for ultrahigh-resolution spectral-domain volumetric OCT imaging," Opt. Lett. 39(7), 2016-2019 (2014). 8. P. H. Tran, D. S. Mukai, M. Brenner, and Z. Chen, "In vivo endoscopic optical coherence tomography by use of a rotational microelectromechanical system probe," Opt. Lett. 29(11), 1236-1238 (2004). Goodnow, and C. Petersen, "Micromotor endoscope catheter for in vivo, ultrahigh-resolution optical coherence tomography," Opt. Lett. 29(19), 2261-2263 (2004). 10. T.-H. Tsai, B. Potsaid, Y. K. Tao, V. Jayaraman, J. Jiang, P. J. S. Heim, M. F. Kraus, C. Zhou, J. Hornegger, H.Mashimo, A. E. Cable, and J. G. Fujimoto, "Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology," Biomed. Opt. Express 4(7), 1119-11...

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Using attenuation coefficients from optical coherence tomography as markers of vocal fold maturation

Abstract: NA Laryngoscope, 126:E218-E223, 2016.

Cited by 18 publications

References 33 publications

Quantitative evaluation of the human vocal fold extracellular matrix using multiphoton microscopy and optical coherence tomography

Quantitative evaluation of the human vocal fold extracellular matrix using multiphoton microscopy and optical coherence tomography

Extratympanic Observation of Middle and Inner Ear Structures in Rodents Using Optical Coherence Tomography

Endoscopic optical coherence tomography: technologies and clinical applications [Invited]

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