The article deals with the problems of using new digital services to organize the development and implementation of agent-individualized work trajectories of human-machine systems adapted to digital industries in the formation of a digital infrastructure for scientific, technical and industrial activities in Russia and abroad. The overall goal of digitally operating with the intellectual activity of innovative agents (scientists, engineers, managers) is to optimize [through the use of communication technologies implemented based on digital information and computing services] the processes of research, design, production and operation during the life cycle of high-tech equipment for industries industries with high requirements for the reliability of technological processes. A system organization of support for agent-oriented configuration of human-machine systems within agent-oriented associations based on the use of various forms of digital information and computing services to support intellectual activity with a significant creative component is proposed.