Using Appetitive Motivation to Train Mice for Spatial Learning in the Barnes Maze
Brigitta Tekla Tajti,
Ojin Yoon,
Aliz Judit Ernyey
et al.
Abstract:The Barnes maze, a well-known spatial-learning paradigm, is based on the innate fear of rodents of large open spaces and their drive to hide. However, additional aversive stimuli (strong light and threatening sounds) are often necessary to provoke the hiding response while rendering the method cumbersome and more stressful. Our objective was to establish a Barnes maze-learning paradigm in mice using palatable food as a reward. After habituating male C57BL6/J or NMRI mice to the reward, the experimenter and the… Show more
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