Using AOP-Wiki to support the ecotoxicological risk assessment of nanomaterials: first steps in the development of novel adverse outcome pathways

Jagiełło, Karolina; Judzinska, Beata; Sosnowska, Anita; Lynch, Iseult; Halappanavar, Sabina; Puzyn, Tomasz

doi:10.1039/d1en01127h

Cited by 3 publications

(2 citation statements)

References 26 publications

(41 reference statements)

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“…To date, the majority of AOP-building effort has been focussed in human health and mammalian studies, but the application of AOPs for model organisms such as Daphnia is increasingly being investigated (Song et al, 2020). While in principle AOPs are chemical-agnostic, and focussed more on mechanisms, such as endocrine disruption or ion-channel blocking, for example, work is underway to establish NMs-specific AOPs, focussing on key aspects such as NMs-biomolecule interactions, NM-membrane interactions, and NMs-induced disruption of enzyme activity, for example, Jagiello et al found that only 8 of 331 available AOPs in the AOP-Wiki are specific for NMs (namely,AOP numbers 144,173,207,208,209,210,241,and 319), meaning that only 2.4% of all AOPs in the AOP-Wiki have (as of 2022) been assessed or considered for their direct relevance to NMs, and thus there is a need to evaluate whether remaining AOPs might be applicable fully or partially to NMs (Jagiello et al, 2022).…”

Section: Adverse Outcome Pathways-gaps In Terms Of Ecotoxicity and Nmsmentioning

confidence: 99%

Daphnia as a model organism to probe biological responses to nanomaterials—from individual to population effects via adverse outcome pathways

et al. 2023

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The importance of the cladoceran Daphnia as a model organism for ecotoxicity testing has been well-established since the 1980s. Daphnia have been increasingly used in standardised testing of chemicals as they are well characterised and show sensitivity to pollutants, making them an essential indicator species for environmental stress. The mapping of the genomes of D. pulex in 2012 and D. magna in 2017 further consolidated their utility for ecotoxicity testing, including demonstrating the responsiveness of the Daphnia genome to environmental stressors. The short lifecycle and parthenogenetic reproduction make Daphnia useful for assessment of developmental toxicity and adaption to stress. The emergence of nanomaterials (NMs) and their safety assessment has introduced some challenges to the use of standard toxicity tests which were developed for soluble chemicals. NMs have enormous reactive surface areas resulting in dynamic interactions with dissolved organic carbon, proteins and other biomolecules in their surroundings leading to a myriad of physical, chemical, biological, and macromolecular transformations of the NMs and thus changes in their bioavailability to, and impacts on, daphnids. However, NM safety assessments are also driving innovations in our approaches to toxicity testing, for both chemicals and other emerging contaminants such as microplastics (MPs). These advances include establishing more realistic environmental exposures via medium composition tuning including pre-conditioning by the organisms to provide relevant biomolecules as background, development of microfluidics approaches to mimic environmental flow conditions typical in streams, utilisation of field daphnids cultured in the lab to assess adaption and impacts of pre-exposure to pollution gradients, and of course development of mechanistic insights to connect the first encounter with NMs or MPs to an adverse outcome, via the key events in an adverse outcome pathway. Insights into these developments are presented below to inspire further advances and utilisation of these important organisms as part of an overall environmental risk assessment of NMs and MPs impacts, including in mixture exposure scenarios.

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Section: Adverse Outcome Pathways-gaps In Terms Of Ecotoxicity and Nmsmentioning

confidence: 99%

Daphnia as a model organism to probe biological responses to nanomaterials—from individual to population effects via adverse outcome pathways

et al. 2023

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“…Although at present, the development of NM-related adverse outcome pathways has mainly focused on human toxicity, an additional nanosafety component to consider in risk assessment of this class of material is eco-toxicity [8]. The unique physicochemical properties of NMs enable them to interact with biomolecules and change essential biochemical pathways.…”

Section: Introductionmentioning

confidence: 99%

Catfish as an Ecotoxicological Model for Assessment of Nanoparticle Toxicity Profiling

Atamanalp¹,

Uçar²,

Alak³

2022

Catfish - Advances, Technology, Experiments

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The developing technological infrastructure has accelerated the evolution of nanoscience and encouraged the use of nanomaterials in very large areas. However, environmental liberation of nanomaterials can pose potential risks. Although different toxicity screening methodologies have been successfully used to assess the potential risks of these substances, little is known about their environmental impact. Fish are the most visible members of the aquatic ecosystem, vulnerable to toxicants. Although the ecotoxicology of fish and nanoparticles are complex, this review evaluates approaches to using catfish as a bio-indicator for the effects of nanoparticles on fish.

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A computational view on nanomaterial intrinsic and extrinsic features for nanosafety and sustainability

et al. 2023

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Using AOP-Wiki to support the ecotoxicological risk assessment of nanomaterials: first steps in the development of novel adverse outcome pathways

Abstract: Currently, the development of Adverse Outcome Pathways (AOPs) that are relevant for nanomaterials (NMs) is focusing mainly on their human toxicity. However, there is an additional component of nanosafety that...

Cited by 3 publications

References 26 publications

Daphnia as a model organism to probe biological responses to nanomaterials—from individual to population effects via adverse outcome pathways

Daphnia as a model organism to probe biological responses to nanomaterials—from individual to population effects via adverse outcome pathways

Catfish as an Ecotoxicological Model for Assessment of Nanoparticle Toxicity Profiling

A computational view on nanomaterial intrinsic and extrinsic features for nanosafety and sustainability

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