Using anti-Müllerian hormone to identify a good prognosis group in women of advanced reproductive age

Fridén, Barbro; Sjöblom, Peter; Menezes, Judith

doi:10.1111/j.1479-828x.2011.01374.x

Cited by 35 publications

(18 citation statements)

References 18 publications

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“…Our results are in line with those previously reported by other authors showing that AMH is a useful marker for predicting cycle cancelation [38] and poor response to ovarian stimulation [5], representing a better predictor than the other classically associated parameters such as FSH, estradiol and age [39]. Interestingly, our data show the special importance of serum AMH in women aged >38 yr or with high serum FSH, and have immediate application for the clinician and the patient in their decision prior to start hormonal stimulation.…”

Section: Discussionsupporting

confidence: 94%

Prediction of Reproductive Outcomes According to Different Serum Anti-Müllerian Hormone Levels in Females Undergoing Intracystoplasmic Sperm Injection

Olmedo¹,

Vincentiis²,

Martino³

et al. 2013

PLoS ONE

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Background and aim of the studySerum anti-Müllerian hormone (AMH) is a reliable marker of ovarian reserve, and it has been shown to be correlated with reproductive outcomes in grouped analyses. However, practical data is scarce for the physician and the patients to predict these outcomes in an individual couple according to serum AMH measured prior to assisted reproduction technology (ART) procedures.Study DesignTo address this question, we performed an analytic observational study including 145 females undergoing intracytoplasmic sperm injection (ICSI) in a single center. Results were analyzed according to serum AMH; subgroup analyses were performed by grouping patients according to patient’s age and FSH levels.ResultsThe risk of cycle cancelation decreased from 64% in patients with serum AMH ≤3 pmol/L (0.42 ng/mL) to 21% with AMH ≥15 pmol/L (2.10 ng/mL). Cycle cancelation occurred in approximately two-thirds of the patients with AMH ≤ 3 pmol/L irrespective of the FSH level. However, with higher AMH values the risk of cycle cancelation decreased more significantly in patients with normal FSH. The rate of good response increased from almost null in patients with AMH ≤3 pmol/L to 61% in those with AMH ≥15 pmol/L. The positive correlation between good response and AMH was also significant, but with lower absolute rates, when patients were grouped according to their age or FSH levels. Pregnancy rate increased moderately, but significantly, from 31% with AMH ≤3 pmol/L to 35% with AMH ≥15 pmol/L.ConclusionsWe provide estimates of reproductive outcomes according to individualized values of serum AMH, in general and in subgroups according to patient’s age or serum FSH, which are helpful for the clinician and the couple in their decision making about starting an assisted reproductive treatment.

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Section: Discussionsupporting

confidence: 94%

Prediction of Reproductive Outcomes According to Different Serum Anti-Müllerian Hormone Levels in Females Undergoing Intracystoplasmic Sperm Injection

Olmedo¹,

Vincentiis²,

Martino³

et al. 2013

PLoS ONE

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“…In the present work we have used a practical approach and provide useful and easily applicable results of serum AMH levels to predict the risk of cycle cancellation and the chances of good response to controlled ovarian hyperstimulation and pregnancy in females undergoing an ART procedure, according to their age or FSH level. Our results are in line with those previously reported by other authors showing that AMH is a useful marker for predicting cycle cancellation (Friden et al 2011) and poor response to ovarian stimulation (Broer et al 2009), representing a better predictor than the other classically associated parameters such as FSH, estradiol and age (Jayaprakasan et al 2010). Interestingly, our data show the special importance of serum AMH in women aged >38 Table 2.…”

Section: Discussionsupporting

confidence: 82%

Serum AMH level can predict the risk of cycle cancellation and the chances of good ovarian response, independently of patient's age or FSH

Calamera¹,

Buffone²,

Vincentiis³

et al. 2013

JBRA Assisted Reproduction

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Objective: In the recent years, anti-Müllerian hormone (AMH) has been shown to represent a reliable marker of the ovarian reserve. In this study, we evaluate the risk of cycle cancellation and the chances of good ovarian response to controlled hyperstimulation and of pregnancy according to serum AMH measured prior to assisted reproduction procedures in females undergoing intracytoplasmic sperm injection. Method: An analytic observational study included females undergoing ICSI between in a single center. Subgroup analyses were performed by grouping patients according to FSH levels or to their age. Results: The risk of cycle cancellation decreased from rate of good response increased from almost null in Conclusion:Here we provide estimates of those outcomes according to the values of serum AMH, in general and in subgroups according to patient's age or serum FSH, which are helpful for the clinician and the couple in their decision making about starting an ART treatment.

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“…A further very interesting and clinically useful paper is presented by Friden et al. 4 confirming the widely reported evidence that a low serum Anti‐Mullerian hormone (AMH) is a useful predictor of ovarian response to stimulation as part of an IVF cycle for an older woman. This is particularly useful at predicting patients who have a poor ovarian reserve and a hence a limited response to ovarian stimulation.…”

supporting

confidence: 59%

Current themes in reproductive medicine

Hart

2011

Australian and New Zealand Journal of Obstetrics and Gynaecology

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Using anti-Müllerian hormone to identify a good prognosis group in women of advanced reproductive age

Abstract: Anti-Müllerian hormone is useful for identifying a good prognosis group in women of advanced reproductive age.

Cited by 35 publications

References 18 publications

Prediction of Reproductive Outcomes According to Different Serum Anti-Müllerian Hormone Levels in Females Undergoing Intracystoplasmic Sperm Injection

Prediction of Reproductive Outcomes According to Different Serum Anti-Müllerian Hormone Levels in Females Undergoing Intracystoplasmic Sperm Injection

Serum AMH level can predict the risk of cycle cancellation and the chances of good ovarian response, independently of patient's age or FSH

Current themes in reproductive medicine

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