Using an advanced intercross line to identify quantitative trait loci controlling immune response during collagen-induced arthritis

Yu, Xinhua; Bauer, Kristin; Wernhoff, Patrik; Ibrahim, Saleh M.

doi:10.1038/sj.gene.6364385

Cited by 9 publications

(7 citation statements)

References 30 publications

(28 reference statements)

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“…This mapping resolution is high compared to previous results in arthritis using AIL, or partial AIL,45 46 47 48 49 and it approaches the mapping results for Ncf1 and APLEC in congenic strains (<0.6Mb).…”

Section: Discussionsupporting

confidence: 60%

Definition of arthritis candidate risk genes by combining rat linkage-mapping results with human case-control association data

Bäckdahl

Guo

Jagodic

et al. 2008

Annals of the Rheumatic Diseases

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Section: Discussionsupporting

confidence: 60%

Definition of arthritis candidate risk genes by combining rat linkage-mapping results with human case-control association data

Bäckdahl

Guo

Jagodic

et al. 2008

Annals of the Rheumatic Diseases

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“…Inbred strains also show some degree of differential susceptibility to the disease because of their genetic differences [42, 43]. In our genetic analyses, sixteen genomic regions were identified to be associated with disease in at least two RA mouse models, some of which were overlapping between different RA mouse models [44].…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

Cytokines and Cytokine Profiles in Human Autoimmune Diseases and Animal Models of Autoimmunity

Kunz

Ibrahim²

2009

Mediators of Inflammation

141

108

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The precise pathomechanisms of human autoimmune diseases are still poorly understood. However, a deepened understanding of these is urgently needed to improve disease prevention and early detection and guide more specific treatment approaches. In recent years, many new genes and signalling pathways involved in autoimmunity with often overlapping patterns between different disease entities have been detected. Major contributions were made by experiments using DNA microarray technology, which has been used for the analysis of gene expression patterns in chronic inflammatory and autoimmune diseases, among which were rheumatoid arthritis, systemic lupus erythematosus, psoriasis, systemic sclerosis, multiple sclerosis, and type-1 diabetes. In systemic lupus erythematosus, a so-called interferon signature has been identified. In psoriasis, researchers found a particular immune signalling cluster. Moreover the identification of a new subset of inflammatory T cells, so-called Th17 T cells, secreting interleukin (IL)-17 as one of their major cytokines and the identification of the IL-23/IL-17 axis of inflammation regulation, have significantly improved our understanding of autoimmune diseases. Since a plethora of new treatment approaches using antibodies or small molecule inhibitors specifically targeting cytokines, cellular receptors, or signalling mechanisms has emerged in recent years, more individualized treatment for affected patients may be within reach in the future.

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“…Mapping experiments using AILs in animals and plants have been published (Iraqi et al 2000;Hazen et al 2003;Wang et al 2003;Jagodic et al 2004;Hernandez-Valladares et al 2004;Scott and Duvick 2005;Yu et al 2007;Balint-Kurti et al 2007Rodriguez et al 2008;Capelle et al 2010). In maize, the IBM population (for Intermated B73 3 Mo17, Lee et al 2002), is widely used by the maize international community for high-density genetic mapping Fu et al 2006) and fine mapping of traits of interest (Hazen et al 2003;Scott and Duvick 2005;Balint-Kurti et al 2007Rodriguez et al 2008).…”

Section: Q Uantitative Trait Loci (Qtl) Mapping Providesmentioning

confidence: 99%

The Genetic Architecture of Grain Yield and Related Traits in Zea maize L. Revealed by Comparing Intermated and Conventional Populations

Huang¹,

Madur

Combes

et al. 2010

Genetics

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Using advanced intermated populations has been proposed as a way to increase the accuracy of mapping experiments. An F 3 population of 300 lines and an advanced intermated F 3 population of 322 lines, both derived from the same parental maize inbred lines, were jointly evaluated for dry grain yield (DGY), grain moisture (GM), and silking date (SD). Genetic variance for dry grain yield was significantly lower in the intermated population compared to the F 3 population. The confidence interval around a QTL was on average 2.31 times smaller in the intermated population compared to the F 3 population. One controversy surrounding QTL mapping is whether QTL identified in fact represent single loci. This study identifies two distinct loci for dry grain yield in the intermated population in coupling phase, while the F 3 identifies only a single locus. Surprisingly, fewer QTL were detected in the intermated population than the F 3 (21 vs. 30) and ,50% of the detected QTL were shared among the two populations. Crossvalidation showed that selection bias was more important in the intermated population than in the F 3 and that each detected QTL explained a lower percentage of the variance. This finding supports the hypothesis that QTL detected in conventional populations correspond mainly to clusters of linked QTL. The actual number of QTL involved in the genetic architecture of complex traits may be substantially larger, with effect sizes substantially smaller than in conventional populations.

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Using an advanced intercross line to identify quantitative trait loci controlling immune response during collagen-induced arthritis

Cited by 9 publications

References 30 publications

Definition of arthritis candidate risk genes by combining rat linkage-mapping results with human case-control association data

Definition of arthritis candidate risk genes by combining rat linkage-mapping results with human case-control association data

Cytokines and Cytokine Profiles in Human Autoimmune Diseases and Animal Models of Autoimmunity

The Genetic Architecture of Grain Yield and Related Traits in Zea maize L. Revealed by Comparing Intermated and Conventional Populations

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