Using advanced biotechnological techniques to improve cannabis cultivars

In the weeds: A comprehensive review of cannabis; its chemical complexity, biosynthesis, and healing abilities

“…Additionally, cannabis micropropagation allows for rapid multiplication while maintaining genetic integrity. Integrating gene editing methods to modify RNA and regulate gene expression within cannabis offers further tools to precisely control or modify biosynthetic pathways, thereby achieving desired cannabis characteristics [170] . However, the biosynthetic origin and genetic regulation of many potentially therapeutically relevant compounds is still unknown, limiting the possibilities of controlling biochemical pathways, as metabolic engineering in yeast and cell-free platforms are not yet compatible with commercial-scale production, while molecular pharming through the development of cell cultures is complicated by the complexity of cannabinoids at low molar concentrations [188] …”