Using acellular aortic matrix to repair umbilical hernias of calves

Kumar, Vineet; Kumar, Naveen; Gangwar, AK; Saxena, Abhishek

doi:10.1111/avj.12058

Cited by 23 publications

(26 citation statements)

References 10 publications

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“…2012) and umbilical hernias in calves (Kumar et al . 2013a) and later on it was tried in clinical cases in equids. Informed consent in writing was obtained from the client owned cases.…”

Section: Discussionmentioning

confidence: 99%

“…These results were in accordance with Kumar et al . (2012, 2013a,b,c). Recurrence of the hernia is a relatively common complication of herniorrhaphy and has been reported after repair using sutures alone (Cook et al .…”

Section: Discussionmentioning

confidence: 99%

“…2012) and umbilical hernias in calves (Kumar et al . 2013a). The acellular matrix possesses the appropriate mechanical properties and induces appropriate interaction with the host cells that resulted in the regeneration of functional tissues (Voytik‐Harbin et al .…”

Section: Discussionmentioning

confidence: 99%

“…2012; Kumar et al . ). Therefore, the present study was undertaken to evaluate the efficacy of EDC‐crosslinked AAM of buffalo origin for the repair of inguinal hernias in horses.…”

Section: Introductionmentioning

confidence: 97%

“…2012; Kumar et al . 2013a,b,c). The potential benefits of biological materials include improved infection resistance, host tissue ingrowth and less adhesion formation (Gaertner et al .…”

Section: Introductionmentioning

confidence: 99%

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An acellular aortic matrix of buffalo origin crosslinked with 1‐ethyl‐3‐3‐dimethylaminopropylcarbodiimide hydrochloride for the repair of inguinal hernia in horses

Kumar

Singh

et al. 2013

Equine Veterinary Education

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An acellular aortic matrix (AAM) crosslinked with 1-ethyl-3-3-dimethylaminopropylcarbodiimide hydrochloride (EDC) was evaluated for the repair of inguinal hernias in 5 horses. The aorta from buffalo was acellularised using 1% sodium dodecyl sulfate (SDS) and 0.25% trypsin. The AAM was crosslinked with 1% EDC. Under anaesthesia, inguinal hernias were repaired with EDC-crosslinked AAM graft using an inlay graft technique. Blood samples collected on Days 0, 15 and 30 post implantation, were used for SDS polyacrylamide gel electrophoresis (PAGE) analysis to assess the animals' serum protein concentration, and gelatin zymography for the identification of matrix metalloproteinases. All animals that underwent hernia repair demonstrated successful healing without clinical signs of wound dehiscence, infection or recurrence during a 6-month follow-up period. SDS-PAGE analysis of serum protein concentrations revealed that, this was increased at Day 15 and had decreased again at Day 30. Gelatin zymography of serum of implanted horses expressed a band of 92 kDa, corresponding to MMP-9 activity. The relative amount of the 92 kDa band was higher at Day 15 as compared to Days 0 and 30. It may be concluded that EDC-crosslinked AAM of buffalo origin can be used safely in horses for the repair of inguinal hernia with adequate strength and minimal foreign body reaction.

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“…2012) and umbilical hernias in calves (Kumar et al . 2013a) and later on it was tried in clinical cases in equids. Informed consent in writing was obtained from the client owned cases.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…2012; Kumar et al . ). Therefore, the present study was undertaken to evaluate the efficacy of EDC‐crosslinked AAM of buffalo origin for the repair of inguinal hernias in horses.…”

Section: Introductionmentioning

confidence: 97%

“…2012; Kumar et al . 2013a,b,c). The potential benefits of biological materials include improved infection resistance, host tissue ingrowth and less adhesion formation (Gaertner et al .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations