Using Abdominal CT Data for Visceral Fat Evaluation

M, Pop; Pop, Raluca

doi:10.2478/amma-2013-0058

Cited by 3 publications

(2 citation statements)

References 13 publications

(16 reference statements)

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“…Segmentation of adipose tissue was performed by Image J.51u software, where a tomography slice of each animal was used to count the Hounsfield unit (HU)-scale pixels corresponding to the fat tissue of the animals. ImageJ is public domain software that is well used in automatic or manual image processing in studies related to adipose tissue segmentation [53,54,55].…”

Section: Methodsmentioning

confidence: 99%

Olive Oil, Palm Oil, and Hybrid Palm Oil Distinctly Modulate Liver Transcriptome and Induce NAFLD in Mice Fed a High-Fat Diet

Sales

Medeiros

Spreafico

et al. 2018

IJMS

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Nonalcoholic fatty liver disease (NAFLD) is highly prevalent worldwide. The most severe form is nonalcoholic steatohepatitis (NASH). Among risk factors for the development of NAFLD is excessive lipid intake. Since palm (P) oil is the most consumed oil in the world, we aimed to investigate the effects of high-fat diets made with P oil, hybrid palm (HP) oil, or olive (O) oil in liver. Twenty-four male mice (C57Bl/6J) were fed a high-fat diet (41% fat) containing P, HP, or O oils for 8 weeks and compared to a control (C) group fed a chow diet. Adiposity was measured with computed tomography. Body, adipose tissue, and liver weights, as well as liver fat (Bligh–Dyer), blood lipid profile, glucose, and liver enzymes were measured. Liver histology (hematoxylin–eosin) and transcriptome (microarray-based) were performed. ANOVA tests with Newman–Keuls were used. Body weight was increased in the P group (p < 0.001) and body fat in the O group (C vs. O p ≤ 0.01, P vs. O p ≤ 0.05, HP vs. O p ≤ 0.05). All high-fat diets disturbed the blood lipid profile and glucose, with marked effects of HP on very low-density lipoprotein cholesterol (VLDL), triglycerides, and alkaline phosphatase (p ≤ 0.001). HP had the highest liver fat (42.76 ± 1.58), followed by P (33.94 ± 1.13). O had a fat amount comparable to C (16.46 ± 0.34, 14.71 ± 0.70, respectively). P and HP oils induced hepatocyte ballooning. Transcriptome alterations of the O group were related to amino acid metabolism and fatty acid (FA) metabolism, the P group to calcium ion homeostasis, and HP oil to protein localization. Both P and HP oils induced NASH in mice via disturbed hepatocyte transcription. This raises concerns about the content of these oils in several industrialized foods.

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Section: Methodsmentioning

confidence: 99%

Olive Oil, Palm Oil, and Hybrid Palm Oil Distinctly Modulate Liver Transcriptome and Induce NAFLD in Mice Fed a High-Fat Diet

Sales

Medeiros

Spreafico

et al. 2018

IJMS

View full text Add to dashboard Cite

show abstract

“…Total adipose tissue (TAT) was calculated as the sum of the two areas. The use of CT images to determine abdominal fat depots is widely used (33) and images at L3-level of the lumbar spine has been shown to offer the highest prediction of total SAT and VAT depots in the body compared with CT images at other levels of the lumbar spine (34).…”

Section: Study Design and Populationmentioning

confidence: 99%

Change in abdominal obesity after colon cancer surgery – effects of left-sided and right-sided colonic resection

Dolin,

Nybing,

Ali

et al. 2023

Preprint

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Background Excess abdominal visceral adipose tissue (VAT) is associated with metabolic diseases and poor survival in colon cancer (CC). We assessed the impact of different types of CC surgery on changes in abdominal fat depots. Material and Methods Computed tomography (CT)-scans performed preoperative and 3 years after CC surgery were analyzed at L3-level for VAT, subcutaneous adipose tissue (SAT) and total adipose tissue (TAT) areas. We assessed changes in VAT, SAT, TAT and VAT/SAT ratio after 3 years and compared the changes between right-sided and left-sided resected patients in the total population and in men and women separately. Results A total of 134 stage I-III CC patients undergoing cancer surgery were included. Left-sided colonic resected patients had a 5% (95% CI: 2% - 9%, p<0.01) increase in abdominal VAT, a 4% (95% CI: 2% - 6%, p<0.001) increase in SAT and a 5% increase (95% CI: 2% - 7%, p<0.01) in TAT after 3 years. Right-sided colonic resected patients had no change in VAT, but a 6% (95% CI: 4% - 9%, p<0.001) increase in SAT and a 4% (95% CI: 1% - 7%, p<0.01) increase in TAT after 3 years. Stratified by sex, only males undergoing left-sided colonic resection had a significantly VAT increase of 6% (95% CI: 2% - 10%, p<0.01) after 3 years. Conclusion Left-sided CC resection was associated with a significant VAT increase after 3 years.

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Change in abdominal obesity after colon cancer surgery – effects of left-sided and right-sided colonic resection

Kays Mohammed Ali,

Dolin,

Damm Nybing

et al. 2024

Int J Obes

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Background Excess abdominal visceral adipose tissue (VAT) is associated with metabolic diseases and poor survival in colon cancer (CC). We assessed the impact of different types of CC surgery on changes in abdominal fat depots. Material and methods Computed tomography (CT)-scans performed preoperative and 3 years after CC surgery were analyzed at L3-level for VAT, subcutaneous adipose tissue (SAT) and total adipose tissue (TAT) areas. We assessed changes in VAT, SAT, TAT and VAT/SAT ratio after 3 years and compared the changes between patients who had undergone left-sided and right-sided colonic resection in the total population and in men and women separately. Results A total of 134 patients with stage I-III CC undergoing cancer surgery were included. Patients who had undergone left-sided colonic resection had after 3 years follow-up a 5% (95% CI: 2–9%, p < 0.01) increase in abdominal VAT, a 4% (95% CI: 2–6%, p < 0.001) increase in SAT and a 5% increase (95% CI: 2–7%, p < 0.01) in TAT. Patients who had undergone right-sided colonic resection had no change in VAT, but a 6% (95% CI: 4–9%, p < 0.001) increase in SAT and a 4% (95% CI: 1–7%, p < 0.01) increase in TAT after 3 years. Stratified by sex, only males undergoing left-sided colonic resection had a significant VAT increase of 6% (95% CI: 2–10%, p < 0.01) after 3 years. Conclusion After 3 years follow-up survivors of CC accumulated abdominal adipose tissue. Notably, those who underwent left-sided colonic resection had increased VAT and SAT, whereas those who underwent right-sided colonic resection demonstrated solely increased SAT.

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Using Abdominal CT Data for Visceral Fat Evaluation

Cited by 3 publications

References 13 publications

Olive Oil, Palm Oil, and Hybrid Palm Oil Distinctly Modulate Liver Transcriptome and Induce NAFLD in Mice Fed a High-Fat Diet

Olive Oil, Palm Oil, and Hybrid Palm Oil Distinctly Modulate Liver Transcriptome and Induce NAFLD in Mice Fed a High-Fat Diet

Change in abdominal obesity after colon cancer surgery – effects of left-sided and right-sided colonic resection

Change in abdominal obesity after colon cancer surgery – effects of left-sided and right-sided colonic resection

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