Using a Powered Bone Marrow Biopsy System Results in Shorter Procedures, Causes Less Residual Pain to Adult Patients, and Yields Larger Specimens

Berenson, James R.; Yellin, Ori; Blumenstein, Brent A.; Bojanower, Deanna; Jonathan, Croopnick; Aboulafia, David M.; Upadhyaya, Gargi; Spadaccini, Cathy J.

doi:10.1186/1746-1596-6-23

Cited by 50 publications

(44 citation statements)

References 19 publications

(20 reference statements)

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“…Bucher et al 3 showed that biopsy quality was rated ‘sufficient for diagnosis’ in both the control group and in the P-group. Berenson et al 4 and Swords et al also had similar results when comparing the two methods. In fact, a most recent retrospective study done by Lynch and colleagues showed that the manual method provides superior percentage and length of evaluable marrow 6…”

Section: Discussionmentioning

confidence: 70%

Bone marrow biopsies performed by both the powered OnControl drill device and the Jamshidi needle produce adequate specimens

et al. 2017

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Section: Discussionmentioning

confidence: 70%

Bone marrow biopsies performed by both the powered OnControl drill device and the Jamshidi needle produce adequate specimens

et al. 2017

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“…Textbooks and BMA guidelines rarely mention the aspiration technique, and when they do, rapid aspiration is mentioned [2,3,4]. Former studies have examined the impact that biopsy devices, operator profession and experience have on the quality of bone marrow (BM) assessment and pain [1,5,6,7,8,9,10]. To our knowledge, studies on the aspiration technique and its association with specimen quality are sparse.…”

Section: Introductionmentioning

confidence: 99%

Bone Marrow Aspiration: A Randomized Controlled Trial Assessing the Quality of Bone Marrow Specimens Using Slow and Rapid Aspiration Techniques and Evaluating Pain Intensity

et al. 2015

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Background/Aims: Bone marrow aspiration (BMA) is an essential procedure in the examination of hematological disorders, but there is limited evidence as to whether the aspiration rate affects specimen quality. We aimed to assess the specimen quality and pain intensity using slow (S-technique) or rapid (R-technique) aspiration. Methods: This was a single-center, prospective, randomized patient- and assessor-blinded study of 482 patients scheduled for BMA. Specimen quality was evaluated by grading bone marrow (BM) cellularity and counting the number of marrow particles. Pain was assessed using a visual analog scale (VAS). Results: We found a significant difference between the 2 groups with regard to the quality of specimens. For cellularity, the odds ratio (OR) for having a poor quality aspirate using the S-technique versus the R-technique was 3.05 [confidence interval (CI) 1.79-5.31]. For BM particles, the quality of specimens with the S-technique proved to be poor compared with the R-technique (OR 2.52; CI 1.51-4.28). We found a statistically significant difference of 1 VAS point (p < 0.001) of the median pain intensity in favor of the S-technique. Conclusion: Even though the pain intensity is significantly higher with the R-technique, the median difference is relatively small. We propose that the R-technique is preferable to the S-technique due to better specimen quality.

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“…[12][13][14][15][16][17][18][19] Of these eight, two were excluded 13 18 as they were abstracts of follow on published manuscripts. One additional study was excluded as it was an interim analysis of a single arm validation study.…”

Section: Included Studiesmentioning

confidence: 99%

A powered bone marrow biopsy system versus manual methods: a systematic review and meta-analysis of randomised trials

Voigt¹,

Mosier

2013

J Clin Pathol

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A significant number of bone marrow biopsies are performed annually. Outcomes of patient pain and sample size of biopsy are important issues as perception of patient pain is underestimated by clinicians and sample size assists in accurate diagnosis. Manual extraction of marrow biopsy is the main method used. Recently a powered system has been introduced. The objectives of this systematic review and meta-analysis were to determine if the powered system reduces patient pain and improves sample capture. A PubMed and Cochrane search for randomised controlled trials was undertaken comparing the powered system with manual methods. Risk of bias assessment and meta-analysis of outcomes using appropriate statistical methods were performed. Five randomised controlled trials were identified. Patient pain (measured via visual analogue scale (VAS)—100 point scale) was significantly reduced using the powered system: mean difference=−6.57; 95% CI −12.93 to −0.22; p=0.04. The relative reduction in pain was 17%–25% with the powered system. Sample biopsy size (length in mm) was also significantly increased with the powered system: mean difference=3.65 mm; 95%; CI 1.61 mm to 5.68 mm; p=0.0005. The relative increase in sample size was 33% with the powered system. Operator ease of use (as measured via VAS) and adverse events were similar. Despite limited operator experience, patients experienced less pain and sample sizes were increased without an increase in adverse events with the powered system. The powered system may offer an option in obtaining samples from patients whose pain is compromised by disease and may reduce redos.

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Using a Powered Bone Marrow Biopsy System Results in Shorter Procedures, Causes Less Residual Pain to Adult Patients, and Yields Larger Specimens

Cited by 50 publications

References 19 publications

Bone marrow biopsies performed by both the powered OnControl drill device and the Jamshidi needle produce adequate specimens

Bone marrow biopsies performed by both the powered OnControl drill device and the Jamshidi needle produce adequate specimens

Bone Marrow Aspiration: A Randomized Controlled Trial Assessing the Quality of Bone Marrow Specimens Using Slow and Rapid Aspiration Techniques and Evaluating Pain Intensity

A powered bone marrow biopsy system versus manual methods: a systematic review and meta-analysis of randomised trials

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