Uses of Polypodium leucotomos Extract in Oncodermatology

Calzari, Paolo; Vaienti, Silvia; Nazzaro, Gianluca

doi:10.3390/jcm12020673

Cited by 6 publications

(7 citation statements)

References 79 publications

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“…In addition, PLE inhibits the oxidation of glutathione and acts as a direct ROS absorber against superoxide anion, hydroxyl, oxygen and oxygen peroxide. It can stimulate IL-10 production and promote a shift in the cytokine profile from type 1 to type 2 T cells [ 135 ]. Middelkamp-Hup et al compared the use of PL in combination with NB-UVB therapy in a double-blind, placebo-controlled, clinical trial [ 136 ].…”

Section: Potential Therapeutic Approaches To Reduce Oxidative Stressmentioning

confidence: 99%

Oxidative Stress and Potential Antioxidant Therapies in Vitiligo: A Narrative Review

Białczyk,

Wełniak,

Kamińska

et al. 2023

Mol Diagn Ther

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Vitiligo is a chronic skin disorder characterised by the loss of melanocytes and subsequent skin depigmentation. Although many theories have been proposed in the literature, none alone explains the pathogenesis of vitiligo. Oxidative stress has been identified as a potential factor in the pathogenesis of vitiligo. A growing body of evidence suggests that antioxidant therapies may offer a promising approach to managing this condition. This review summarises the potential mechanisms of oxidative stress and the types of melanocyte death in vitiligo. We also provide a brief overview of the most commonly studied antioxidants. Melanocytes in vitiligo are thought to be damaged by an accumulation of reactive oxygen species to destroy the structural and functional integrity of their DNA, lipids, and proteins. Various causes, including exogenous and endogenous stress factors, an imbalance between prooxidants and antioxidants, disruption of antioxidant pathways, and gene polymorphisms, lead to the overproduction of reactive oxygen species. Although necroptosis, pyroptosis, ferroptosis, and oxeiptosis are newer types of cell death that may contribute to the pathophysiology of vitiligo, apoptosis remains the most studied cell death mechanism in vitiligo. According to studies, vitamin E helps to treat lipid peroxidation of the skin caused by psoralen ultra-violet A treatment. In addition, Polypodium leucotomos increased the efficacy of psoralen ultra-violet A or narrow-band ultraviolet B therapy. Our review provides valuable insights into the potential role of oxidative stress in pathogenesis and antioxidant-based supporting therapies in treating vitiligo, offering a promising avenue for further research and the development of effective treatment strategies.

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Section: Potential Therapeutic Approaches To Reduce Oxidative Stressmentioning

confidence: 99%

Oxidative Stress and Potential Antioxidant Therapies in Vitiligo: A Narrative Review

Białczyk,

Wełniak,

Kamińska

et al. 2023

Mol Diagn Ther

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“…In the field of oncology, a recent review by Calzari et al (2023) elucidates the ways in which PLE functions and assesses its applications in oncodermatology, with reference to both in vitro and in vivo research [13]. However, this review is not the only one, as the trend in recent years has been to publish literature reviews demonstrating the photoprotective effects of PLE, thereby confirming its therapeutic potential against various types of cancerous growths.…”

Section: Oncodermatologymentioning

confidence: 99%

Clinical Applications of Polypodium leucotomos (Fernblock®): An Update

Rodríguez-Luna

Zamarrón

Juarranz

et al. 2023

Life

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Exposure to sun radiation leads to higher risk of sunburn, pigmentation, immunosuppression, photoaging and skin cancer. In addition to ultraviolet radiation (UVR), recent research indicates that infrared radiation (IR) and visible light (VIS) can play an important role in the pathogenesis of some of these processes. Detrimental effects associated with sun exposure are well known, but new studies have shown that DNA damage continues to occur long after exposure to solar radiation has ended. Regarding photoprotection strategies, natural substances are emerging for topical and oral photoprotection. In this sense, Fernblock®, a standardized aqueous extract of the fern Polypodium Leucotomos (PLE), has been widely administered both topically and orally with a strong safety profile. Thus, this extract has been used extensively in clinical practice, including as a complement to photodynamic therapy (PDT) for treating actinic keratoses (AKs) and field cancerization. It has also been used to treat skin diseases such as photodermatoses, photoaggravated inflammatory conditions and pigmentary disorders. This review examines the most recent developments in the clinical application of Fernblock® and assesses how newly investigated action mechanisms may influence its clinical use.

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“…[81][82][83][84] Containing high phenolic compounds content with their antioxidant activity, the PLE suppresses superoxide anions, lipoperoxides and hydroxyl radicals, ameliorates DNA repair and acts as photoprotectant, antimutagenic, anti-inflammatory and immune modulator therapeutic modality. 85,86 PLE suppresses COX-2 levels, promotes p53 expression and decreases prostaglandin-mediated inflammation linked to photoaging in mice. Those effects have not yet been demonstrated in humans.…”

Section: P Olyp Odium Leucotomos E X Tr Ac Tmentioning

confidence: 99%

“…An additional important nutraceutical against the cutaneous carcinogenic process is the Polypodium leucotomos extract (PLE/Fernblock®, IFC Group, Spain), initially studied in hairless mice 81–84 . Containing high phenolic compounds content with their antioxidant activity, the PLE suppresses superoxide anions, lipoperoxides and hydroxyl radicals, ameliorates DNA repair and acts as photoprotectant, antimutagenic, anti‐inflammatory and immune modulator therapeutic modality 85,86 . PLE suppresses COX‐2 levels, promotes p53 expression and decreases prostaglandin‐mediated inflammation linked to photoaging in mice.…”

Section: Polypodium Leucotomos Extractmentioning

confidence: 99%

“…PLE suppresses COX‐2 levels, promotes p53 expression and decreases prostaglandin‐mediated inflammation linked to photoaging in mice. Those effects have not yet been demonstrated in humans 86 . However, it has been available in Europe since 2001 and in the US since 2006 as a dietary supplement aimed at “protecting against sun‐related effects and aging.” PLE showed beneficial effects in the alleviation of UVB Phototoxicity in various human cutaneous diseases like photodermatoses, pigmentary disorders and actinic keratoses 85 .…”

Section: Polypodium Leucotomos Extractmentioning

confidence: 99%

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Nutraceutical strategies for alleviation of UVB phototoxicity

McCarty

Benzvi

Vojdani

et al. 2023

Experimental Dermatology

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The two main types of non-melanoma skin cancers (NMSCs) are: basal-cell and squamous-cell skin cancers. The first one grows slowly, damaging the skin; however, it is unlikely to spread. In contrast, squamous-cell skin cancer is more aggressive and invasive, with higher morbidity and mortality. Both represent the most common cancers worldwide, at least in sunny countries, and their incidences have been continuously rising in the last few decades. 1 Basal-cell carcinoma is much more prevalent than the squamous cell type; their ratio depends on geoepidemiology, ethnicity and gender.In the USA, prevalence, incidence, disability-adjusted life years and mortality rates for squamous cell carcinoma per 100 000 persons in 2019 were 314, 262, 26.6 and 0.8, respectively; and for basal cell carcinoma, were 51.2, 525, 0.2 and zero, respectively. 2 Sun-derived ultraviolet (UV) radiation is responsible for more than 90% of the cases. The recent surge in incidence is due to enhance UV exposure, notably reflecting thinning of the ozone layer and the common use of tanning beds. 3 Lighter skinned people are at increased risk, and genetic or acquired compromise of immune function also increases

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Uses of Polypodium leucotomos Extract in Oncodermatology

Cited by 6 publications

References 79 publications

Oxidative Stress and Potential Antioxidant Therapies in Vitiligo: A Narrative Review

Oxidative Stress and Potential Antioxidant Therapies in Vitiligo: A Narrative Review

Clinical Applications of Polypodium leucotomos (Fernblock®): An Update

Nutraceutical strategies for alleviation of UVB phototoxicity

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