Uses of Nanoemulsions in Pharmaceuticals Industries

Elshamy, Abdelsamed I.; El-Kashak, Walaa A.; Taher, Rehab F.; Elghonemy, Mai M.; Ahmed, Rania F.; Mohamed, Tarik A.; Essa, Ahmed F.; Ragab, Tamer I. M.; Abdelhameed, Mohamed F.; El-Gendy, Abd El-Nasser G.; Nassar, Mahmoud I.; Abd-ELGawad, Ahmed M.; Farrag, Abdel Razik H.; Abd-Alla, Howaida I.; Hegazy, Mohamed-Elamir F.

doi:10.1007/978-981-99-5398-1_15

Cited by 2 publications

(1 citation statement)

References 130 publications

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“…Biodistribution of the drug was improved and decreased toxicity with multidrug resistances. Several propolis nanoformulations have been found and proven to have biological effects such as antidiabetic, hepatoprotective, anticancer and others [ 29 ]. Formulation types include solid lipid nanoparticles, liposomes, transferosomes, and polymeric nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

New insights of propolis nanoformulation and its therapeutic potential in human diseases

Kustiawan,

Syaifie,

Siregar

et al. 2024

ADMET DMPK

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Background and purpose: Scientific research is crucial to develop therapies for various disease severity levels, as modern drugs cause side effects and are difficult to predict. Researchers are exploring herbal alternatives with fewer side effects, particularly propolis, which has been validated through in vitro, in vivo, and clinical studies. This will focus on scientific evidence and its supporting technology for developing new bioactive compounds for chronic diseases. Nanotechnology can improve the delivery and absorption of herbal medicines, which often have poor bioavailability due to their high molecular weight and solubility in water, particularly in oral medicines. This technology can enhance propolis's effects through multi-target therapy and reduce side effects. Experimental approach: All publications related to each section of this review were discovered using the search engines Google Scholar, Scopus, and Pubmed. This was only available for publication between 2013 and 2023. The selected publications were used as references in this review after being thoroughly studied. Key results: Evaluation of propolis active compounds, the classification of propolis nano formulations, design concepts, and mechanisms of action of propolis nano formulation. Additionally, the challenges and prospects for how these insights can be translated into clinical benefits are discussed. Conclusion: In the last ten years, a list of nanoformulation propolis has been reported. This review concludes the difficulties encountered in developing large-scale nanoformulations. To commercialize them, improvements in nano carrier synthesis, standardized evaluation methodology within the framework of strategy process improvement, and Good Manufacturing Practices would be required.

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Section: Introductionmentioning

confidence: 99%

New insights of propolis nanoformulation and its therapeutic potential in human diseases

Kustiawan,

Syaifie,

Siregar

et al. 2024

ADMET DMPK

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Uncovering and evaluating coconut oil-loaded silica nanoemulsion as anti-viral, bacterial, and fungal: synthesis, fabrication, characterization, and biosafety profiles

Elnosary,

Aboelmagd,

Sofy

et al. 2024

Beni-Suef Univ J Basic Appl Sci

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Background Coconut oil, a natural component abundant in terpenoids, possesses various physiological functions. The global concern over the spread of viral infections and antimicrobial-resistant bacteria and fungi has highlighted the need for novel treatments. Coconut oil, with its known antimicrobial properties, presents an attractive candidate for combating these pathogens. This study aims to investigate the potential of coconut oil-loaded silica nanoemulsion (ON@SiO2) as a novel therapeutic agent against viral, antimicrobial-resistant bacteria, and fungal pathogens. Results The study synthesized coconut oil-loaded silica nanoemulsion (ON@SiO2) using an eco-friendly, cost-effective method with native coconut oil (CO). Characterization confirmed successful synthesis on the nanoscale with good distribution. Three nanoemulsion samples (ON-1@SiO2, ON-2@SiO2, and ON-3@SiO2) were prepared, with average particle sizes of 193 nm, 200 nm, and 325 nm, respectively. Evaluation of cytotoxicity on Vero-E6 cell lines indicated safety of ON-0@SiO2 and ON-3@SiO2, with CC50 values of 97.5 mg/ml and 89.1 mg/ml, respectively. ON-3@SiO2 demonstrated anti-Herpes I and II (HSV1 and HSV2) activity, with IC50 values of 1.9 mg/ml and 2.1 mg/ml, respectively. Additionally, ON-3@SiO2 exhibited promising antibacterial activity against E. coli, P. aeruginosa, S. aureus, and B. subtilis, with MIC values of 25 mg/ml, 12.5 mg/ml, 25 mg/ml, and 3.12 mg/ml, respectively. Conclusions ON-3@SiO2 showed potential antifungal activity against C. albicans, a unicellular fungus, with an MIC of 12.5 mg/ml. Overall, ON@SiO2 possesses antiviral, antibacterial, and antifungal properties.

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Uses of Nanoemulsions in Pharmaceuticals Industries

Cited by 2 publications

References 130 publications

New insights of propolis nanoformulation and its therapeutic potential in human diseases

New insights of propolis nanoformulation and its therapeutic potential in human diseases

Uncovering and evaluating coconut oil-loaded silica nanoemulsion as anti-viral, bacterial, and fungal: synthesis, fabrication, characterization, and biosafety profiles

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