Uses of Multi-Objective Flux Analysis for Optimization of Microbial Production of Secondary Metabolites

Abstract

Secondary metabolites are not essential for the growth of microorganisms, but they play a critical role in how microbes interact with their surroundings. In addition to this important ecological role, secondary metabolites also have a variety of agricultural, medicinal, and industrial uses, and thus the examination of secondary metabolism of plants and microbes is a growing scientific field. While the chemical production of certain secondary metabolites is possible, industrial-scale microbial production is a green and economically attractive alternative. This is even more true, given the advances in bioengineering that allow us to alter the workings of microbes in order to increase their production of compounds of interest. This type of engineering requires detailed knowledge of the “chassis” organism’s metabolism. Since the resources and the catalytic capacity of enzymes in microbes is finite, it is important to examine the tradeoffs between various bioprocesses in an engineered system and alter its working in a manner that minimally perturbs the robustness of the system while allowing for the maximum production of a product of interest. The in silico multi-objective analysis of metabolism using genome-scale models is an ideal method for such examinations.

Isolation of Secondary Metabolites From Marine Actinobacterium of Microbispora sp.T3S11 and Their Antibacterial Activities

“…Furthermore, many actinobacterial secondary metabolites have found applications in medicine, agriculture, and industry due to their pharmacological and biotechnological importance. These compounds’ diverse chemical structures contribute to a wide range of activities, including antibacterial, antifungal, antiviral, and anticancer properties [ 17 ]. Secondary metabolites’ antibacterial and antimicrobial properties have the potential to be useful in the treatment of a variety of infectious diseases that are resistant to current antibiotics.…”

Sustainable Countermeasures for Skin Health Improvement for Green Consumers: The Utilization of Hsian-Tsao during Global Warming

“…This can be understood as related to the impact on biota redistribution. Accordingly, the Kyoto Protocol mandated specific solutions, such as reducing CO 2 levels by 7% by 2011 [1,73,[81][82][83][84][85][86][87][88][89][90][91][92]. Fossil fuel economies, population growth, and the consequent industrialization worldwide further increase the importance of green industries as they regard land use, urbanization, and agricultural productivity.…”