Uses of<i>Withania somnifera</i>(Linn) Dunal (Ashwagandha) in Ayurveda and its Pharmacological Evidences

Meher, Sudhanshu Kumar; Das, Banmali; Panda, Purnendu; Bhuyan, G. C.; Rao, M Mruthyumjaya

doi:10.5958/2321-5836.2016.00006.9

Cited by 13 publications

(7 citation statements)

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“…Apart from this, it is also proven to have various immunomodulatory, anti-inflammatory and antianxiety properties. 15,16 Raju et al in his study showed that when given at a dose of 300 mg/kg, Ashwagandha greatly reduced the mean duration of hindlimb tonic flexion and extension, clonus, and stupor, and there was no postictal depression in PTZ induced seizure models. 15 In our study, Ashwagandha extract given at a dose of 300 mg/kg produced marked anti-epileptic action.…”

Section: Discussionmentioning

confidence: 97%

Comparing the antiepileptic effects of atorvastatin, celecoxib, ashwagandha, clove oil, and Sodium valproate on chemo-shock induced seizures in male Wistar albino rats

George

Krishnadas²,

Thennavan³

et al. 2023

Int J Basic Clin Pharmacol

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Background: Antiepileptic potential of statins, COX inhibitors and other herbal medications are to be evaluated in experimental animals so that the most efficacious can be translated for human use as an adjunct to the commonly used anti-epileptic drugs. Methods: This experimental animal study grouped 30 male Wistar albino rats into 6 groups with each containing 5 rats of which one group was control, one was the standard drug and the other 4 were treatment groups which received Atorvastatin, Celecoxib, Ashwagandha and Clove oil. These drugs were administered 30 minutes prior to administering Pentylene-tetrazole which induced convulsions and the various seizure parameters were analysed. The blood samples of the animals were also assessed for anti-oxidant activity by measuring superoxide dismutase and catalase levels in the blood. Results: The onset of seizure was significantly delayed by Ashwagandha (2.55±0.94), similar to the latency shown by the standard drug (2.09±1.21). The duration of convulsions was very significantly reduced in all the 5 drug groups in comparison to the control (p<0.001). The clonic jerk duration was not reduced as effectively as the standard drug. The duration of recovery time amongst the various groups was also significant (p<0.05). The SOD and Catalase levels of no groups showed any possible association between the anti-epileptic efficacy of these drugs and the anti-oxidant enzyme levels. Conclusions: Ashwagandha has good anti-epileptic efficacy not less than the standard drug when the various drug groups were compared.

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Section: Discussionmentioning

confidence: 97%

Comparing the antiepileptic effects of atorvastatin, celecoxib, ashwagandha, clove oil, and Sodium valproate on chemo-shock induced seizures in male Wistar albino rats

George

Krishnadas²,

Thennavan³

et al. 2023

Int J Basic Clin Pharmacol

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“…W. somnifera has played a role in human society since prehistoric times. Its medicinal nature is specified in Ayurvedic books, such as Astanga Hridaya , Bhava Prakasha Nighantu , Charaka Samhita , and Sushruta Samhita [ 12 , 28 , 37 ]. Its Ayurvedic properties are Atishukrala, boosts semen quality and quantity; Balya, which provides power; Vajikara (andrology), which enhances sensual problems; Kshayapaha, which helps to treat weakness and provides nutritive conditions; Rasayani (chemotaxis), which rejuvenates the body and removes toxins; Shwitrapaha, which heals white discoloration of the skin; and Shothahara, which treats swelling in tissue and clears impurities (Ama).…”

Section: Biodiversity Of W Somniferamentioning

confidence: 99%

“…W. somnifera is also known as sukrala , i.e., it helps to increase semen, and is regarded as an aphrodisiac. The powdered plant mixed with ghee, sugar and milk is taken to treat puerperal backache and leucorrhea caused by endometritis [ 28 , 29 ].…”

Section: Biological Activitymentioning

confidence: 99%

Biodiversity, Biochemical Profiling, and Pharmaco-Commercial Applications of Withania somnifera: A Review

et al. 2023

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Withania somnifera L. Dunal (Ashwagandha), a key medicinal plant native to India, is used globally to manage various ailments. This review focuses on the traditional uses, botany, phytochemistry, and pharmacological advances of its plant-derived constituents. It has been reported that at least 62 crucial and 48 inferior primary and secondary metabolites are present in the W. somnifera leaves, and 29 among these found in its roots and leaves are chiefly steroidal compounds, steroidal lactones, alkaloids, amino acids, etc. In addition, the whole shrub parts possess various medicinal activities such as anti-leukotriene, antineoplastic, analgesic, anti-oxidant, immunostimulatory, and rejuvenating properties, mainly observed by in vitro demonstration. However, the course of its medical use remains unknown. This review provides a comprehensive understanding of W. somnifera, which will be useful for mechanism studies and potential medical applications of W. somnifera, as well as for the development of a rational quality control system for W. somnifera as a therapeutic material in the future.

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“…Possible overdose can also cause gastrointestinal problems and vomiting, so treatment should be started with small doses and gradually increased. Ashwagandha is not recommended during pregnancy or in cases of hyperthyroidism [ 51 ]. Chronic stress increases cortisol levels leading to lower levels of triiodothyronine and thyroxine.…”

Section: Specific Nootropic Herb Shrub and Tree Speciesmentioning

confidence: 99%

Nootropic Herbs, Shrubs, and Trees as Potential Cognitive Enhancers

Malík

Tlustos

2023

Plants

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Plant-based nootropics are a diverse group of natural drugs that can improve cognitive abilities through various physiological mechanisms, especially in cases where these functions are weakened or impaired. In many cases, the nootropics enhance erythrocyte plasticity and inhibit aggregation, which improves the blood’s rheological properties and increases its flow to the brain. Many of these formulations possess antioxidant activity that protects brain tissue from neurotoxicity and improves the brain’s oxygen supply. They can induce the synthesis of neuronal proteins, nucleic acids, and phospholipids for constructing and repairing neurohormonal membranes. These natural compounds can potentially be present in a great variety of herbs, shrubs, and even some trees and vines. The plant species reviewed here were selected based on the availability of verifiable experimental data and clinical trials investigating potential nootropic effects. Original research articles, relevant animal studies, meta-analyses, systematic reviews, and clinical trials were included in this review. Selected representatives of this heterogeneous group included Bacopa monnieri (L.) Wettst., Centella asiatica (L.) Urban, Eleutherococcus senticosus (Rupr. & Maxim.) Maxim., Ginkgo biloba L., Lepidium meyenii Walp., Panax ginseng C.A. Meyer, Paullinia cupana Kunth, Rhodiola rosea L., Schisandra chinensis (Turcz.) Baill., and Withania somnifera (L.) Dunal. The species are depicted and described, together with their active components and nootropic effects, and evidence of their efficacy is presented. The study provides brief descriptions of the representative species, their occurrence, history, and the chemical composition of the principle medicinal compounds, with uses, indications, experimental treatments, dosages, possible side effects, and contraindications. Most plant nootropics must be taken at optimal doses for extended periods before measurable improvement occurs, but they are generally very well tolerated. Their psychoactive properties are not produced by a single molecule but by a synergistic combination of several compounds. The available data suggest that including extracts from these plants in medicinal products to treat cognitive disorders can have substantial potential therapeutic benefits.

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Uses ofWithania somnifera(Linn) Dunal (Ashwagandha) in Ayurveda and its Pharmacological Evidences

Cited by 13 publications

References 0 publications

Comparing the antiepileptic effects of atorvastatin, celecoxib, ashwagandha, clove oil, and Sodium valproate on chemo-shock induced seizures in male Wistar albino rats

Comparing the antiepileptic effects of atorvastatin, celecoxib, ashwagandha, clove oil, and Sodium valproate on chemo-shock induced seizures in male Wistar albino rats

Biodiversity, Biochemical Profiling, and Pharmaco-Commercial Applications of Withania somnifera: A Review

Nootropic Herbs, Shrubs, and Trees as Potential Cognitive Enhancers

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