Uses of eye drops in dermatology, literature review

El-Amawy, Heba Saed

doi:10.1080/09546634.2022.2079598

Cited by 3 publications

(2 citation statements)

References 85 publications

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“…Brimonidine is a highly selective α2‐adrenergic receptor agonist with potent vasoconstrictive effects, 13 which in its gel form, was approved by the FDA in August 2013 for the topical treatment of persistent facial erythema of rosacea in adults; 14 however, it is not officially available in most middle east countries. Since medication absorption through the skin and eye tissue seems similar, commercially available eye drops could be used to treat skin diseases when topical therapies are unavailable or unaffordable 15 . Meanwhile, topical timolol maleate 0.5% eye drops showed good efficacy in treating infantile hemangiomas 16 .…”

Section: Introductionmentioning

confidence: 99%

“…Since medication absorption through the skin and eye tissue seems similar, commercially available eye drops could be used to treat skin diseases when topical therapies are unavailable or unaffordable. 15 Meanwhile, topical timolol maleate 0.5% eye drops showed good efficacy in treating infantile hemangiomas. 16 The aim of the present study is to clinically and histologically evaluate the use and effectiveness of topical brimonidine tartrate 0.2% eye drops for the management of facial erythema in patients with rosacea.…”

Section: Introductionmentioning

confidence: 99%

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Topical brimonidine for the management of facial erythema in rosacea: a histological, histometric, and immunohistochemical study

et al. 2023

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Background Facial erythema in rosacea is a troublesome embarrassing presentation with limited options of treatment. Daily brimonidine gel was shown to be an effective modality of treatment. Being unavailable in Egypt and the scarcity of objective evaluation of its therapeutic effect motivated the search for other alternatives.Objective To evaluate the use and effectiveness of topical brimonidine eye drops for the management of facial erythema in rosacea with the aid of objective assessment. MethodsThe study was conducted on 10 rosacea patients presented with facial erythema.Brimonidine tartrate eye drops 0.2% were applied twice daily for 3 months on areas of red facial skin. Punch biopsies were obtained before and after 3 months of treatment. Routine hematoxylin and eosin (H&E) staining as well as CD34 immunohistochemical staining were performed for all biopsies. Sections were examined to detect the changes in the count and the surface area of blood vessels.Results Evaluation of clinical results showed good improvement of facial redness at the end of treatment (55-75%). Only 10% of subjects expressed rebound erythema. H&E and CD34 stained sections showed an increased count of dilated dermal blood vessels, which decreased significantly after treatment in count and surface area (P = 0.005, and P = 0.004, respectively). Conclusion Topical brimonidine eye drops proved to be effective in managing facial erythema in rosacea, providing an available and cheaper alternative to brimonidine gel.The study improved the subjective evaluation in the context of objective assessment of treatment efficacy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Topical brimonidine for the management of facial erythema in rosacea: a histological, histometric, and immunohistochemical study

et al. 2023

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Are cyclosporine eye drops a suitable treatment in ocular rosacea?

Prados-Carmona

Galvez‐Moreno

et al. 2022

Journal of Dermatological Treatment

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From Eye Care to Hair Growth: Bimatoprost

Zeppieri,

Gagliano,

Spadea

et al. 2024

Pharmaceuticals

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Background: Bimatoprost has emerged as a significant medication in the field of medicine over the past several decades, with diverse applications in ophthalmology, dermatology, and beyond. Originally developed as an ocular hypotensive agent, it has proven highly effective in treating glaucoma and ocular hypertension. Its ability to reduce intraocular pressure has established it as a first-line treatment option, improving management and preventing vision loss. In dermatology, bimatoprost has shown promising results in the promotion of hair growth, particularly in the treatment of alopecia and hypotrichosis. Its mechanism of action, stimulating the hair cycle and prolonging the growth phase, has led to the development of bimatoprost-containing solutions for enhancing eyelash growth. Aim: The aim of our review is to provide a brief description, overview, and studies in the current literature regarding the versatile clinical use of bimatoprost in recent years. This can help clinicians determine the most suitable individualized therapy to meet the needs of each patient. Methods: Our methods involve a comprehensive review of the latest advancements reported in the literature in bimatoprost formulations, which range from traditional eye drops to sustained-release implants. These innovations offer extended drug delivery, enhance patient compliance, and minimize side effects. Results: The vast literature published on PubMed has confirmed the clinical usefulness of bimatoprost in lowering intraocular pressure and in managing patients with glaucoma. Numerous studies have shown promising results in dermatology and esthetics in promoting hair growth, particularly in treating alopecia and hypotrichosis. Its mechanism of action involves stimulating the hair cycle and prolonging the growth phase, leading to the development of solutions that enhance eyelash growth. The global use of bimatoprost has expanded significantly, with applications growing beyond its initial indications. Ongoing research is exploring its potential in glaucoma surgery, neuroprotection, and cosmetic procedures. Conclusions: Bimatoprost has shown immense potential for addressing a wide range of therapeutic needs through various formulations and advancements. Promising future perspectives include the exploration of novel delivery systems such as contact lenses and microneedles to further enhance drug efficacy and patient comfort. Ongoing research and future perspectives continue to shape its role in medicine, promising further advancements and improved patient outcomes.

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Uses of eye drops in dermatology, literature review

Cited by 3 publications

References 85 publications

Topical brimonidine for the management of facial erythema in rosacea: a histological, histometric, and immunohistochemical study

Topical brimonidine for the management of facial erythema in rosacea: a histological, histometric, and immunohistochemical study

Are cyclosporine eye drops a suitable treatment in ocular rosacea?

From Eye Care to Hair Growth: Bimatoprost

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