Usefulness of total bladder capacity and post-void residual urine volume as a predictor of detrusor overactivity with impaired contractility in stroke patients

Abstract

Detrusor overactivity (DO) with impaired contractility (DOIC) is a mixed pattern of involuntary contraction and increased post-void residual urine volume (PVR) which occurs in stroke patients. Urodynamic study results obtained from patients with detrusor abnormalities and stroke were analyzed to identify the associations between various urodynamic parameters and DOIC. Between August 2003 and November 2010, 127 patients were selected from 178 patients undergoing urodynamic study due to urinary symptoms. Stroke patients were divided into three groups: the DO, DOIC and detrusor underactivity (DU) groups. The significance of differences between the three groups was analyzed using the Kruskal-Wallis test and receiver operating characteristic (ROC) curves were used to calculate the accuracy of the urodynamic study result factors to distinguish between the three groups. The average total bladder capacity (TBC) was 219.15±98.30 ml in the DO, 330.25±115.75 ml in the DOIC and 486.00±111.48 ml in the DU (P<0.001) group. The average PVR was 22.64±20.85 ml in the DO, 146.87±95.09 ml in the DOIC and 425.33±136.70 ml in the DU (P<0.001) group. A ROC curve of DO and DOIC revealed that TBC and PVR were significantly different between the DOIC and DO groups. The area under the curve (AUC) of TBC was 0.812 (P<0.001) and that of PVR was 0.987 (P<0.001). A ROC curve of DOIC and DU revealed that TBC and PVR were significantly different between the DOIC and DU groups. The AUC of TBC was 0.813 (P<0.001) and that of PVR was 0.929 (P<0.001). In the urodynamic study of stroke patients with urinary symptoms, TBC and PVR may provide useful information for treating patients who cannot undergo urodynamic study.

New mouse model of underactive bladder developed by placement of a metal ring around the bladder neck

“…Our cystometric analysis of bladder function after 16 weeks of BOO (UAB group) revealed marked reductions in bladder pressure parameters and an increase in bladder compliance, which are indicative of bladder underactivity. The decreases in bladder pressures and increases in infusion volume and bladder compliance observed in the UAB group are consistent with previous clinical reports, 25,26 and these changes are likely due to an increase in collagen deposition and reduced smooth muscle contractility 18 . Experiments in rats have shown that chronic obstruction leads to impaired detrusor contractile function and a gradual decline in bladder emptying 18 .…”

İnme Hastalarında Nörojenik Alt Üriner Sistem Disfonksiyonunun Değerlendirilmesi

“…Post void residual (PVR) was 22.64±20.85 mL in the DO group, 146.87±95.09 mL in the DOIC group, and 425.33±136.70 mL in the DU group. It was reported that total bladder capacity and PVR may provide useful information for the treatment of patients who are unable to undergo urodynamic examination (19).…”

Using Search Trends to Analyze Web-Based Interest in Lower Urinary Tract Symptoms-Related Inquiries, Diagnoses, and Treatments in Mainland China: Infodemiology Study of Baidu Index Data

“…The prevalence of voiding difficulty significantly increases with age and the degree of pelvic organ prolapse [ 39 , 40 ]. Additionally, voiding symptoms such as weak streams, hesitancy, and strained urination are especially prevalent in females when other comorbidities are present [ 41 ]. Specifically, the pooled incidence rate of voiding difficulty is 21.3% and 15.5% in males and females, respectively [ 42 ].…”