Usefulness of the FDG PET/CT in the management of cystic echinococcosis: A pilot study

Salvador, Fernando; Escolà-Vergé, Laura; Barios, Marta; Belhassen‐García, Moncef; Tamayo-Alonso, Pilar; Sánchez-Montalvà, Adrián; Romero‐Alegría, Ángela; Simó, Marc; García-Talavera, P.; Bosch-Nicolau, Pau; Espinosa-Pereiro, Juan; Molina, Israel

doi:10.1016/j.actatropica.2021.106295

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…Only one patient (CE5) had increased 18F-FDG uptake. The authors concluded that there was no correlation between FDG-PET/CT imaging and CE bioactivity [38 ▪▪ ].…”

Section: Diagnosismentioning

confidence: 97%

Cystic echinococcosis of the bone

Monge-Maillo,

Lopez-Velez

2023

Current Opinion in Infectious Diseases

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Purpose of review Cystic echinococcosis (CE) has a wide world distribution causing important morbidity. Osseous involvement is present in less than 4% of the CE cases. Its diagnosis and therapeutic management is full of challenges and low grade of evidence. Recent findings The study summarizes literature evidence on the management of osseous CE with particular emphasis on new data regarding diagnosis and treatment. Summary Clinical presentation of osseous CE depends on the skeletal area affected. Diagnosis is mostly based on radiological findings and serology. Recent advances with qPCR on osseous tissue samples seem to be a good option for diagnosis confirmation. Complete resection of the cystic lesion is the only curative option, but it is usually not possible performing palliative surgery and prolonged albendazole intake in most cases. Radiotherapy could be an option, but experience to date is only based on clinical cases.

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“…Only one patient (CE5) had increased 18F-FDG uptake. The authors concluded that there was no correlation between FDG-PET/CT imaging and CE bioactivity [38 ▪▪ ].…”

Section: Diagnosismentioning

confidence: 97%

Cystic echinococcosis of the bone

Monge-Maillo,

Lopez-Velez

2023

Current Opinion in Infectious Diseases

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“…Several studies published in the last decade have explored the usefulness of advanced imaging techniques, including ultrasound elastography, CT, and DW-MRI, for the differential diagnosis of cystic echinococcosis and other lesions; however, results were variable and overall disappointing when coming to clinical usefulness [16][17][18][19][20][21][22][23]. FDG-PET/CT, which has a defined role in alveolar echinococcosis, has been also applied to cystic echinococcosis, with potential usefulness to evaluate the presence of inflammatory complications [24][25][26], but not for evaluation of CE cysts in terms of viability [27].…”

Section: Updates On Imaging Techniques For the Etiological Diagnosis ...mentioning

confidence: 99%

‘No cyst, no echinococcosis’: a scoping review update on the diagnosis of cystic echinococcosis after the issue of the WHO-IWGE Expert Consensus and current perspectives

Siles‐Lucas

Uchiumi

Tamarozzi

2023

Current Opinion in Infectious Diseases

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Purpose of review In 2010, the WHO-Informal Working Group on Echinococcosis (IWGE) published an Expert Consensus on the diagnosis and treatment of echinococcal infections. We provide an update on the diagnosis of cystic echinococcosis through a scoping review of the literature published after the release of the WHO-IWGE document. Recent findings Ultrasound accurately and reliably depicts the pathognomonic signs of cystic echinococcosis (CE) stages compared with other imaging techniques. Among these, T2-wighted MRI is to be preferred to computed tomography, which has poor performance for the etiological diagnosis of CE. A negative serology cannot exclude the diagnosis of CE, while a positive serology, applied after the visualization of a CE-compatible lesion, may confirm a CE diagnosis. Serology alone must not be used to define ‘CE’ nor as ‘screening’ tool for infection. Other imaging and laboratory techniques did not show clinically applicable performances. Summary In the absence of a focal lesion compatible with a CE cyst, no diagnosis of CE should be attempted. There is urgent need to achieve univocal CE case definitions and consensus diagnostic algorithm, as well as standardization of diagnostic methods and issue of a Target Product Profile of CE diagnostics, as advocated by the WHO in the 2021–2030 roadmap for neglected tropical diseases (NTDs).

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