Background-We determined whether estimated hemodynamics from history and physical examination (H&P) reflect invasive measurements and predict outcomes in advanced heart failure. The role of the H&P in medical decision making has declined in favor of diagnostic tests, perhaps because of the lack of evidence for utility. Methods and Results-We compared H&P estimates of filling pressures and cardiac index with invasive measurements in 194 patients in the Evaluation Study of Congestive Heart Failure and Pulmonary Artery Catheterization Effectiveness (ESCAPE) trial. H&P estimates were compared with 6-month outcomes in 388 patients enrolled in ESCAPE. Measured right atrial pressure was Ͻ8 mmHg in 82% of patients with right atrial pressure estimated from jugular veins as Ͻ8 mmHg, and was Ͼ12 mmHg in 70% of patients when estimated as Ͼ12 mmHg. From the H&P, only estimated right atrial pressure Ն12 mmHg (odds ratio, 4.6; PϽ0.001) and orthopnea Ն2 pillows (odds ratio, 3.6; PϽ0.05) were associated with pulmonary capillary wedge pressure Ն30 mmHg. Estimated cardiac index did not reliably reflect the measured cardiac index (Pϭ0.09), but "cold" versus "warm" profile was associated with lower median measured cardiac index (1.75 versus 2.0 L/(min⅐m