Usefulness of the 2005 International Society of Urologic Pathology Gleason grading system in prostate biopsy and radical prostatectomy specimens

Uemura, Hiroji; Hoshino, Koji; Sasaki, Takeshi; Miyoshi, Yasuhide; Ishiguro, Hitoshi; Inayama, Yoshiaki; Kubota, Yoshinobu

doi:10.1111/j.1464-410x.2008.08197.x

Cited by 65 publications

(57 citation statements)

References 30 publications

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“…Regarding the association between the prognostic parameters and biochemical progression in our study, we found a significant association between the conventional parameters including the initial PSa level, gleason score ≥7, and tumor tNM stage with biochemical progression as previously reported by other investigators (37)(38)(39). In addition, early biochemical recurrence was more prevalent in cases with high twist-1, aberrant E-cadherin, and high EZH2 expression.…”

supporting

confidence: 88%

Prognostic value of twist-1, e-cadherin and ezh2 in prostate cancer: an immunohistochemical study

Abdelrahman

Arafa²,

Ahmed³

2017

TJPATH

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Objective: there is an urgent need to identify molecular biomarkers rather than clinical markers to distinguish aggressive prostate cancer from the indolent majority for proper treatment and accurate prediction of prognosis. We aimed to investigate the immunohistochemical expression of epithelial-mesenchymal transition (EMt)-related molecules (twist-1 and E-cadherin) and the stem cell marker EZH2 in prostate cancer and to assess their ability to identify the high-risk patients, in a trial to explore their prognostic implications. Material and Method:Immunohistochemical expression of twist-1, E-cadherin and EZH2 in 50 specimens of prostate cancer and 20 cases of benign prostatic hyperplasia were studied. the relationship between their expression and the clinicopathological variables, biochemical recurrence, and biochemical progression-free survival were investigated. Results:Our results revealed that high twist-1, as well as high EZH2 expression, was strongly associated with higher pre-treatment PSa level, gleason score ≥7, advanced tumor stage, lymph node involvement, distant metastasis and biochemical progression. aberrant E-cadherin expression was significantly associated with higher pre-treatment PSa level, gleason score ≥7, advanced tumor stage, lymph node involvement, and distant metastasis. a significant positive correlation between twist-1 and EZH2 expression was found (p<0.001), while E-cadherin expression showed a negative correlation with both markers (p<0.001). a significant association was found between high twist-1, high EZH2& aberrant E-cadherin expression, and shorter biochemical progression-free survival.Conclusion: the high twist-1 expression, aberrant E-cadherin and high EZH2 expression in primary prostate cancer are considered as adverse prognostic markers of an aggressive tumor with high metastatic potential. assessment of their expression level would contribute to the accurate prediction of biochemical progression.

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supporting

confidence: 88%

Prognostic value of twist-1, e-cadherin and ezh2 in prostate cancer: an immunohistochemical study

Abdelrahman

Arafa²,

Ahmed³

2017

TJPATH

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“…However, it will be some time before a sufficient follow-up period has elapsed to do those studies. Both studies by Uemura et al 23 and Billis et al 11 demonstrated that the Gleason scores on needle biopsies using the modified, but not the original, Gleason system correlated with progression after radical prostatectomy. Tsivian et al 31 similarly found that the modified Gleason score, when analyzed in prognostic grade groups (,7, 7, and .7), predicted biochemical recurrence after radical prostatectomy better than did the original Gleason score groups.…”

Section: Correlation Of Gleason Score With Patient Outcomes Andmentioning

confidence: 99%

“…18,23,24 In a study by Uemura et al, 23 the concordance rates for needle biopsies and radical prostatectomy specimens between the original Gleason system and the ISUP modified system were 67% and 70%, respectively. Similarly, Zareba et al 18 showed the biopsyradical prostatectomy did not significantly affect the Gleason score agreement (63.4% and 65.5%, respectively).…”

mentioning

confidence: 99%

Implications of the International Society of Urological Pathology Modified Gleason Grading System

Egevad¹,

Mazzucchelli²,

Montironi³

2012

Archives of Pathology &Amp; Laboratory Medicine

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Context.—Histologic grading is the clinically most useful tissue-based predictor of prognosis for prostate cancer. Over the years, there has been a gradual shift in how the Gleason grading is applied in practice, with a general trend toward upgrading. A consensus conference was organized in 2005 by the International Society of Urological Pathology (ISUP) for standardizing both the perception of histologic patterns and how the grade information is compiled and reported. Objective.—To review the implications of the ISUP modified Gleason grading system. Data Sources.—Personal experience and review of the current literature. Conclusions.—The recommendations regarding pattern interpretation and reporting are summarized. The practical consequences of the ISUP modification of the Gleason grading are reported. The prognostic importance of the Gleason score, its reproducibility, and its preoperative assessment are discussed. Subsequent proposals for slight modifications to the ISUP grading system are described.

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“…In a similar investigation, Billis and colleagues 10 found that the proportion of cancers with a score of 7 increased from 26% in the classic system to 39% in the ISUP 2005 modified Gleason scoring system; the proportion of cancers with a score of 6 decreased from 68% to 39%. In another study, 11 the ISUP 2005 modified Gleason scoring system resulted in needle biopsy scores that were higher than the scores of the classic system by 16%. In that study, 11 28% of needle biopsy specimens were undergraded or overgraded by the classic system.…”

Section: Commentmentioning

confidence: 95%

Comparison of Classic and International Society of Urological Pathology 2005 Modified Gleason Grading Using Needle Biopsies From the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) Trial

Lucia

Bostwick

Somerville

et al. 2013

Archives of Pathology &Amp; Laboratory Medicine

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Objective.-To compare scores derived using the 2 scoring systems.Design.-On-study and for-cause biopsies were centrally reviewed and assigned a classic Gleason score in the Reduction by Dutasteride of prostate Cancer Events trial. Positive biopsies were reviewed by an independent pathologist in a secondary review using the ISUP 2005 modified Gleason score. The independent pathologist also recorded a classic Gleason score.Results.-In total, 1482/1507 (98%) positive biopsy results were independently reviewed. Scores assigned by the 2 pathologists (classic versus modified) agreed in 83% (1230 of 1481) of cases; 99% (1471 of 1481) of cancers were within 61 of their previous score. Of discordant cases, similar numbers of biopsies were upgraded and downgraded in the secondary review, with minor differences in the score distributions. Interobserver agreement was good, with j values ranging from 0.62 (95% confidence interval [CI], 0.56-0.67) to 0.70 (95% CI, 0.65-0.76). The overall number of high-grade tumors (Gleason score 8-10; n ¼ 48) remained constant between reviews, with 3 fewer cases in the placebo group (n ¼ 16) and 3 more in the dutasteride group (n ¼ 32) in the secondary review. When comparing the independent pathologist's modified scores versus the classic, 17 of 1481 cancers (1.1%) were upgraded (including 9 of 17 upgrades [53%] to high-grade tumors).Conclusions.-This analysis showed similar score distributions between the classic and modified Gleason scoring systems. The differences seen between the 2 pathologists' scores likely reflect differences in interpretation rather than the scoring system chosen.

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Usefulness of the 2005 International Society of Urologic Pathology Gleason grading system in prostate biopsy and radical prostatectomy specimens

Cited by 65 publications

References 30 publications

Prognostic value of twist-1, e-cadherin and ezh2 in prostate cancer: an immunohistochemical study

Prognostic value of twist-1, e-cadherin and ezh2 in prostate cancer: an immunohistochemical study

Implications of the International Society of Urological Pathology Modified Gleason Grading System

Comparison of Classic and International Society of Urological Pathology 2005 Modified Gleason Grading Using Needle Biopsies From the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) Trial

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